全文获取类型
收费全文 | 2662篇 |
免费 | 135篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 108篇 |
妇产科学 | 47篇 |
基础医学 | 471篇 |
口腔科学 | 44篇 |
临床医学 | 253篇 |
内科学 | 471篇 |
皮肤病学 | 119篇 |
神经病学 | 250篇 |
特种医学 | 101篇 |
外科学 | 218篇 |
综合类 | 10篇 |
一般理论 | 1篇 |
预防医学 | 194篇 |
眼科学 | 81篇 |
药学 | 226篇 |
中国医学 | 7篇 |
肿瘤学 | 194篇 |
出版年
2023年 | 17篇 |
2022年 | 29篇 |
2021年 | 66篇 |
2020年 | 32篇 |
2019年 | 68篇 |
2018年 | 53篇 |
2017年 | 48篇 |
2016年 | 63篇 |
2015年 | 62篇 |
2014年 | 102篇 |
2013年 | 129篇 |
2012年 | 184篇 |
2011年 | 166篇 |
2010年 | 102篇 |
2009年 | 70篇 |
2008年 | 163篇 |
2007年 | 157篇 |
2006年 | 177篇 |
2005年 | 128篇 |
2004年 | 123篇 |
2003年 | 123篇 |
2002年 | 118篇 |
2001年 | 37篇 |
2000年 | 29篇 |
1999年 | 37篇 |
1998年 | 32篇 |
1997年 | 36篇 |
1996年 | 24篇 |
1995年 | 22篇 |
1994年 | 17篇 |
1993年 | 21篇 |
1992年 | 23篇 |
1991年 | 17篇 |
1990年 | 20篇 |
1989年 | 13篇 |
1988年 | 24篇 |
1987年 | 20篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1984年 | 16篇 |
1982年 | 18篇 |
1981年 | 12篇 |
1980年 | 10篇 |
1979年 | 13篇 |
1978年 | 12篇 |
1976年 | 12篇 |
1974年 | 8篇 |
1967年 | 12篇 |
1966年 | 9篇 |
1958年 | 7篇 |
排序方式: 共有2802条查询结果,搜索用时 31 毫秒
1.
2.
3.
Dr. Karl Hinrichs Gisela Rost 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1949,263(3-4):294-302
Zusammenfassung Zur Prüfung einer von den Amerikanernvan Slyke undPhillips angegebenen Schnellmethode zur Messung des menschlichens Bluteiweißes wurden 50 Blutspender untersucht und ihre physiologischen Reaktionen nach der Blutentnahme geprüft.Es konnte bestätigt werden, daß beim Blutverlust der Verringerung der kreisenden Blutmenge die entscheidende Bedeutung zukommt. Der Organismus ist bestrebt, die Leere im Kreislauf durch Ausschüttung hämoglobinreicherer Erythrocyten aus den Depotorganen, wie Leber, Milz und subpapillärem Plexus aufzufüllen.Durch Einströmen von Gewebswasser in die Blutbahn kehrt das Kreislaufvolumen zur ursprünglichen Norm zurück, die Erythrocyten verschwinden wieder in ihre Lagerstätten.Zur Erhaltung des kolloidosmotischen Druckes, d. h. zur Retention der eiweißärmeren Gewebsflüssigkeit, werden hydrationsfähige Proteine aus der Leber vornehmlich mobilisiert.Die Wiederauffüllung des Kreislaufs ist in erster Linie eine physikalische Notwendigkeit, zu deren Stabilisierung Gewebs- wie Plasmaproteine beitragen. Das weitere Absinken der Erythrocyten über den 2. Tag hinaus wird mit ihrem hohen Eiweißmolekül erklärt, das in den ersten Tagen nach der Blutentnahme als Plasmaprotein Verwendung findet.Die Tatsache, daß die hier gefundenen Ergebnisse mit bisherigen übereinstimmen, verbunden mit dem Vorteil der sicheren und schnellen Handhabung, lassen die Methode vonvan Slyke undPhillips für die Klinik brauchbar erscheinen.Mit 4 Textabbildungen. 相似文献
4.
Gisela Gamboa Philip M. Carpenter M.D. Yale D. Podnos Guillermo Dorion M.D. Leila Iravani Denis Bolton James T. Mascarello Ph.D. Alberto Manetta M.D. 《Gynecologic oncology》1995,58(3)
We introduce a new epithelial ovarian carcinoma cell line (UCI 107) from a patient with papillary adenocarcinoma of the ovary who had not been previously treated. The growth characteristics, chemosensitivity, tumorgenicity, cytogenetics, antigen expression, and receptor status were examined. A standardized photometric assay was implemented to determine the response to single drug agents including doxorubicin (ADR), cisplatin (CDDP), and Taxol. Tumorgenicity was determined utilizing female athymic mice implanted either subcutaneously (sc) or intraperitoneally (ip) with 1 × 107 UCI 107 cells. UCI 107 cells grow rapidly in culture with lag phase of approximately 48 hr, population doubling time of 24-36 hr, and saturation density of 4.8 × 105 cells/cm2. The 50% inhibitory concentration values for the chemotherapeutic agents were 0.170, 0.029, and 0.330 μM for ADR, Taxol, and CDDP, respectively. Nude mice produced ip tumors within 15 days, resulting in death from carcinomatosis 40-45 days postimplantation. Subcutaneous tumor nodules (100 mm3 were observed in nude mice 12-13 days post-tumor implantation reaching a maximum tumor volume of approximately 10,000 mm3 by Day 30. The cytogenetic composite karyotype is as follows: 46, X, der (X) t (X;7) (p11;q22), inv dup (1) (q12;q32), t (6;6;11;22) (p21.3;q16;q23.3;q13.3), del (13) (q14.1). The cell line expresses progesterone receptor, increased levels of p53 protein, and cytokeratins. It does not appear to express Her-2/neu protein, estrogen receptor, nor the CA 125 tumor marker. In conclusion, UCI 107 displays unique cellular properties which make it an attractive model for the study of ovarian cancer. 相似文献
5.
Ketanserin, a recently developed 5-HT2 receptor antagonist, competitively and selectively blocks the vasoconstrictor activity of 5-hydroxytryptamine (serotonin). We explored a possible contribution of serotonin to augmented vascular tone in patients with severe heart failure, using intravenous and oral formulations of ketanserin. When administered intravenously (10 mg bolus, 4 mg/hr infusion for +/- 40 min) to 10 patients with congestive heart failure (NYHA III or IV) secondary to congestive cardiomyopathy (n = 8) or ischemic heart disease (n = 2), the drug produced a significant increase in cardiac output (rest 24%, p less than 0.001; exercise 19%, p less than 0.01) which was accompanied by a fall in systemic arterial pressure (rest 7%, p less than 0.001; exercise 10%, p less than 0.05) and pulmonary wedge (rest 17%, p less than 0.05; exercise 23%, p less than 0.001) pressure. Calculated systemic vascular resistance (SVR, rest 27%, p less than 0.001; exercise 23%, p less than 0.05) decreased significantly. No significant hemodynamic changes were observed when 40 mg of ketanserin was administered orally to the same group of patients. Plasma catecholamines (norepinephrine, NEP:epinephrine, EP:dopamine) were measured before and after ketanserin at rest and during exercise. Baseline NEP levels were markedly elevated at rest and during exercise in all patients (rest: 878 +/- 381 ng/mL, exercise: 1453 +/- 697 ng/mL). Baseline EP levels were within normal limits. Ketanserin did not produce any change in catecholamine concentration.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
7.
Zuccala G.; Pahor M.; Lattanzio F.; Vagnoni S.; Rodola F.; De Sole P.; Cittadini A.; Cocchi A.; Bernabei R. 《British journal of anaesthesia》1997,79(6):776-781
The use of high-dose magnesium infusions in critically ill and surgical
patients is increasing. This practice is associated with considerable risk
of toxicity, as no reliable criteria are currently available to detect
significant intracellular magnesium depletion. We have evaluated, before
and after surgery, 33 elderly patients with hip fracture, by 24-h Holter
ECG monitoring, Doppler echocardiography and serum chemistry; lymphocyte
magnesium was measured using atomic absorption spectrophotometry. The
severity of ventricular arrhythmias increased, and serum and mononuclear
magnesium concentrations decreased significantly after surgery. Decreases
in either serum magnesium concentrations > 0.125 mmol litre-1 or
cellular magnesium > 6 nmol mg- 1, but not serum or lymphocyte absolute
magnesium concentrations, were associated with postoperative development of
repetitive arrhythmias. Variations in serum magnesium concentrations
correlated with intracellular decreases, and yielded good accuracy in
predicting the postoperative worsening of arrhythmias. Thus perioperative
differences in serum magnesium concentrations reflected intracellular
variations and allowed us to identify patients with clinically relevant
cellular magnesium depletion.
相似文献
8.
Bruno Zappacosta Silvia Persichilli Donata Scribano Angelo Minucci Daniele Lazzaro Pasquale De Sole Bruno Giardina 《Clinical chemistry and laboratory medicine》2002,40(11):1139-1142
Slightly elevated values of homocysteine are commonly associated with thromboembolic diseases, while high values can be found in patients with congenital metabolic defects or nutritional problems. The clinical use of homocysteine as an independent marker of cardiovascular disease was limited in the past by technical problems with its measurement, the instrumentation (HPLC, radioenzymatic assays, gas chromatography-mass spectrometry, etc.) and the necessary skills required. Commercially available immunoassays now permit a simpler and more rapid measurement of homocysteine, that is more suitable for routine clinical laboratories; in this paper we analyze the results obtained by using three fully automated methods for homocysteine determination (Abbott IMx immunoassay, Abbott AxSYM immunoassay and Immulite 2000 homocysteine immunoassay) and their correlation with the widely used HPLC method. The results clearly indicate that all three automated immunochemical methods correlate well with the HPLC method (slope 0.97-1.03; intercept 0.95-1.91 with a recovery above 95% for all three methods). 相似文献
9.
Gisela Enders 《International Journal of Clinical & Laboratory Research》1988,18(1):109-116
Le infezioni microbiche possono mettere a rischio la gravidanza e/o la salute del bambino. Esse possono provocare aumento delia morbilitÀ F. dar luogo, a seconda del momento della gestazione in cui si verificano, ad infezione del prodotto del concepimento, ad aborto, a nascita di un nato morto, a malformazioni, ad alterazioni dello sviluppo, a malattie neonatali e ad infezioni croniche dal decorso variabile. 相似文献
10.
Arend Bökenkamp Bettina Bohnhorst Christian Beier Norbert Albers Gisela Offner Johannes Brodehl 《Pediatric nephrology (Berlin, Germany)》1994,8(2):181-185
Gingival hyperplasia is a common side-effect of immunosuppression with cyclosporine A. Nifedipine is often used to control hypertension in kidney graft recipients. Analysis of gingival status in 106 children transplanted at our centre, and treated either with azathioprine, cyclosporine A or both, revealed significantly higher degrees of gingival overgrowth in those children receiving a combination of cyclosporine A and nifedipine compared with those children treated with cyclosporine A or nifedipine alone. Seven children undergoing gingivectomy at our centre over the past few years had received this combination. After a change in the antihypertensive regimen, avoiding long-term nifedipine medication, and improved dental care with chlorhexidine gel, we noted a reduction in the degree of gingival hyperplasia. In the majority of patients, nifedipine could be replaced by a single drug, usually hydralazine. We therefore recommend avoiding calcium channel blockers in the long-term management of hypertension in patients receiving cyclosporine. 相似文献