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Schistosoma mansoni and HIV acquisition in fishing communities of Lake Victoria,Uganda: a nested case–control study
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Ali Ssetaala Jessica Nakiyingi‐Miiro Gershim Asiki Nassim Kyakuwa Juliet Mpendo Govert J. Van Dam Paul L. Corstjens Pietro Pala Leslie Nielsen Jan De Bont Giuseppe Pantaleo Noah Kiwanuka Pontiano Kaleebu Anatoli Kamali Alison M. Elliott 《Tropical medicine & international health : TM & IH》2015,20(9):1190-1195
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Pilot study of antibodies against varicella zoster virus and human immunodeficiency virus in relation to the risk of developing stroke,nested within a rural cohort in Uganda
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Shukri F. Mohamed Tilahun Nigatu Haregu Olalekan A. Uthman Christopher Khayeka-Wandabwa Stella Kagwiria Muthuri Gershim Asiki Catherine Kyobutungi Paramjit Gill 《Global Heart》2021,16(1)
Background:In the era of double burden of infectious and non-communicable diseases in sub-Saharan Africa, the burden of multimorbidity is likely to be common. However, there is limited evidence on the burden and its associated factors in the sub-Saharan African context.Objective:The aim of this study was to determine the levels and identify determinants of multimorbidity from chronic conditions in two urban slums in Nairobi.Methods:Data collected from 2003 study participants aged 40–60 years in two urban slums of the Nairobi Urban Health and Demographic Surveillance System in 2015 were used. Using self-report, anthropometry and key biomarkers, data on 16 conditions including chronic diseases, behavioral disorders and metabolic abnormalities were gathered. Lifetime multimorbidity defined by the occurrence of at least two chronic conditions in an individual at any time during their life course was computed. Factors associated with lifetime multimorbidity were identified using multiple logistic regression.Findings:A total of 2,081 chronic conditions were identified among 1,302 individuals. While 701 (35.0%) had no chronic condition, single morbidity was reported in 726 (36.2%) of the study population. The overall prevalence of lifetime multimorbidity was 28.7%. The prevalence of dyads and triads of simultaneous occurrences of conditions (episodic multimorbidity) was 20.8% and 6.1%, respectively. Single morbidity was positively associated with gender and alcohol consumption; and negatively associated with employment. Women, older people, the unemployed, current smokers and current alcohol consumers had higher levels of lifetime multimorbidity in the study population.Interpretation:The findings of this study indicate that a considerable proportion of adults living in urban slums experience multimorbidity from chronic conditions. Further studies with a better rigor to establish temporal associations between socio-demographic factors and the occurrence of chronic conditions are needed to explore the impacts and implications on health status and health system. 相似文献
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Sylvia Kusemererwa Andrew Abaasa Martin Onyango Annalene M. Nel Michelle Isaacs Gershim Asiki 《AIDS and behavior》2018,22(1):131-138
Contraceptive preferences of women at risk for HIV acquisition are not well documented. We report on contraceptive choices among women residing in small townships in southwestern Uganda. This was part of preparatory efforts for recruitment into the Ring Study, a phase 3 microbicide trial, between July 2013 and October 2014. Clinicians provided contraceptives per a woman’s choice. HIV testing and screening for other sexually transmitted infections were done at first contact and at screening for the trial. Contraceptive choice was summarized by demographics and regression analysis to show factors associated with use of the injectable method. Of 6725 women contacted, 489 were prescreened. Of these 489 women, most (306, 63%) were already using contraception. Injectables were most preferred (58.7%), followed by implants (23.9%). Women living with a regular sexual partner preferred the injectable method (61.0%, P?=?0.06), compared with other methods. Women at risk for HIV infection are willing to initiate use of modern contraceptives, which may reduce study dropout during intervention trials due to unintended pregnancy. Registration no: NCT01539226. 相似文献
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Frederick M Wekesah Loise Nyanjau Joseph Kibachio Martin K Mutua Shukri F Mohamed Diederick E Grobbee Kerstin Klipstein-Grobusch Christine Ngaruiya Tilahun N Haregu Gershim Asiki Catherine K Kyobutungi 《BMC public health》2018,18(3):1220