全文获取类型
收费全文 | 181篇 |
免费 | 21篇 |
专业分类
耳鼻咽喉 | 65篇 |
基础医学 | 16篇 |
口腔科学 | 3篇 |
临床医学 | 1篇 |
内科学 | 13篇 |
神经病学 | 4篇 |
特种医学 | 3篇 |
外科学 | 56篇 |
综合类 | 1篇 |
预防医学 | 4篇 |
药学 | 2篇 |
中国医学 | 3篇 |
肿瘤学 | 31篇 |
出版年
2021年 | 7篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2017年 | 7篇 |
2016年 | 9篇 |
2015年 | 3篇 |
2014年 | 10篇 |
2013年 | 14篇 |
2012年 | 19篇 |
2011年 | 10篇 |
2010年 | 8篇 |
2009年 | 8篇 |
2008年 | 19篇 |
2007年 | 12篇 |
2006年 | 10篇 |
2005年 | 9篇 |
2004年 | 9篇 |
2003年 | 11篇 |
2002年 | 7篇 |
2001年 | 12篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1991年 | 1篇 |
排序方式: 共有202条查询结果,搜索用时 15 毫秒
1.
Laryngeal Transplantation in 2005: A Review 总被引:3,自引:0,他引:3
M. A. Birchall R. R. Lorenz G. S. Berke E. M. Genden B. H. Haughey M. Siemionow M. Strome 《American journal of transplantation》2006,6(1):20-26
There is no good surgical, medical or prosthetic solution to the problems faced by those with a larynx whose function is irreversibly damaged by tumor or trauma. Over the past 10 years, the pace of research designed to establish laryngeal transplantation as a therapeutic option for these persons has increased steadily. The biggest milestone in this field was the world's first true laryngeal transplant performed in Cleveland, Ohio in 1998. The recipient's graft continues to function well, in many respects, even after 7 years. However, it has also highlighted the remaining barriers to full-scale clinical trials. Stimulated by these observations, several groups have accumulated data which point to answers to some of the outstanding questions surrounding functional reinnervation and immunomodulation. This review seeks to outline the progress achieved in this field by 2005 and to point the way forward for laryngeal transplantation research in the 21st century. 相似文献
2.
3.
Fox DJ Doolabh VB Mackinnon SE Genden EM Hunter DA 《Restorative neurology and neuroscience》1999,15(4):319-326
OBJECT: This study evaluated the dose related effects of Cyclosporin A (CsA) alone and in combination with monoclonal antibodies (mAbs) directed against intercellular adhesion molecule-1 (ICAM-1) and the alpha subunit of leukocyte function-associated antigen (LFA-1 ) on peripheral nerve allograft rejection in a rat model. METHODS: Nerve regeneration was assessed using gait analysis of returning hind limb function, histology, and morphometry. RESULTS: Regeneration comparable to isograft controls and high dose CsA treatment groups was observed when mAbs were used in combi-nation with intermediate dose CsA. Intermediate dose CsA therapy without additional mAbs was insufficient to support this level of regeneration. Nerve allografts treated with high and low dose CsA demonstrated no increased benefit with the addition of mAb therapy. CONCLUSIONS: Thus, mAbs seem to have a dose dependent effect on immunosuppression when used in combination with CsA, and may have therapeutic promise as a rescue therapy when CsA levels fall or issues of toxicity become important. 相似文献
4.
5.
6.
Purevsuren Losol Seung-Hyun Kim Eui-Kyung Hwang Yoo Seob Shin Hae-Sim Park 《Allergy, asthma & immunology research》2013,5(2):106-109
Interleukin 5 (IL-5) is a key cytokine involved in the induction of T-helper type 2 (Th2) responses in the asthmatic airway. We investigated IL-5 genetic polymorphisms associated with asthma phenotypes, including IgE responses to staphylococcal enterotoxins A and B (SEA and SEB, respectively), in asthmatics. Adult asthmatics (n=310) and normal controls (n=160) were enrolled in the present study. Serum total and specific IgE to SEA and SEB were measured. Two IL-5 polymorphisms, -746A>G and +4499T>G, were genotyped using the primer-extension method. There were no significant differences in genotype or haplotype frequencies of these polymorphisms between the two groups. Asthmatics carrying the AG/GG genotype at -746A>G had a significantly higher prevalence of serum specific IgE to SEA (P=0.008), higher total IgE levels (P=0.014), and lower PC20 methacholine levels (P=0.002) compared to those with the AA genotype. These findings suggest that the IL-5 promoter polymorphism at -746A>G enhances serum total and specific IgE responses to SEA, which may augment airway hyperresponsiveness in adult asthmatics. 相似文献
7.
8.
Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing: A report of the 2015 AHNS education committee,AAO‐HNS robotic task force and AAO‐HNS sleep disorders committee
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Neil D. Gross MD F. Christopher Holsinger MD J. Scott Magnuson MD Umamaheswar Duvvuri MD PhD Eric M. Genden MD Tamer AH. Ghanem MD PhD Kathleen L. Yaremchuk MD David Goldenberg MD Matthew C. Miller MD Eric J. Moore MD Luc GT. Morris MD James Netterville Gregory S. Weinstein MD Jeremy Richmon MD 《Head & neck》2016,38(Z1):E151-E158
9.
10.
Preferences and utilities for health states after treatment for oropharyngeal cancer: Transoral robotic surgery versus definitive (chemo)radiotherapy
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)