全文获取类型
收费全文 | 1159篇 |
免费 | 58篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 26篇 |
妇产科学 | 21篇 |
基础医学 | 124篇 |
口腔科学 | 9篇 |
临床医学 | 81篇 |
内科学 | 127篇 |
皮肤病学 | 18篇 |
神经病学 | 210篇 |
特种医学 | 189篇 |
外国民族医学 | 2篇 |
外科学 | 104篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 60篇 |
眼科学 | 135篇 |
药学 | 66篇 |
肿瘤学 | 33篇 |
出版年
2022年 | 11篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 12篇 |
2018年 | 19篇 |
2017年 | 13篇 |
2016年 | 22篇 |
2015年 | 17篇 |
2014年 | 21篇 |
2013年 | 24篇 |
2012年 | 56篇 |
2011年 | 44篇 |
2010年 | 40篇 |
2009年 | 28篇 |
2008年 | 41篇 |
2007年 | 54篇 |
2006年 | 45篇 |
2005年 | 45篇 |
2004年 | 57篇 |
2003年 | 40篇 |
2002年 | 41篇 |
2001年 | 43篇 |
2000年 | 27篇 |
1999年 | 18篇 |
1998年 | 26篇 |
1997年 | 26篇 |
1996年 | 23篇 |
1995年 | 27篇 |
1994年 | 26篇 |
1993年 | 21篇 |
1992年 | 22篇 |
1991年 | 13篇 |
1990年 | 15篇 |
1989年 | 19篇 |
1988年 | 22篇 |
1987年 | 26篇 |
1986年 | 25篇 |
1985年 | 30篇 |
1984年 | 13篇 |
1983年 | 22篇 |
1982年 | 20篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 12篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 14篇 |
1975年 | 7篇 |
1973年 | 7篇 |
1971年 | 7篇 |
排序方式: 共有1229条查询结果,搜索用时 171 毫秒
1.
Jürgen Schlegel Beate Ullrich Gabriele Stumm Peter Gass Ina-Maria Harwerth Nancy E. Hynes Marika Kiessling 《Acta neuropathologica》1993,86(5):473-479
The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demonstrated variable degrees of immunoreactivity in all meningiomas. The intensity of immunostaining correlated with the degree of expression as assessed by Western analysis in 28 meningiomas using polyclonal antiserum 21N. There was no correlation between the degree of expression and histological variants. Immunoreactivity of all menigiomas was distinctly less intense, however, than that of the human breast cancer cell line SK-BR-3, and slightly lower than that of brain metastases of breast and ovarian carcinomas that served as positive controls for both methods. By Southern analysis all meningiomas showed a single copy of the c-erbB-2 gene. Non-neoplastic arachnoid cap cells also exhibited c-erbB-2 expression and the degree of immunoreactivity was comparable with the majority of meningiomas. These data argue against an overexpression of c-erbB-2 in meningiomas, but rather indicate a cell-type-specific constitutive expression of the c-erbB-2 gene product in meningiomas and their putative progenitor cells. Since a subgroup of meningiomas is known to express progesterone receptors (PR), gp185 immunoreactivity was compared to the hormone receptor status using monoclonal antibody KD68. Fifty-six percent meningiomas showed PR immunoreactivity, but there was no statistically significant correlation with the degree of gp185 expression.This study was supported by a grant of the Tumorzentrum Heidelberg/Mannheim (M.K., No. 10028060) 相似文献
2.
3.
4.
5.
A 16-year-old female had multiple retinal capillary angiomas, complicated by marked retinal and optic disc neovascularization, preretinal membranes, and retinal detachment in her right eye. Pars plana lensectomy, vitrectomy, fluid/gas exchange, direct transvitreal diathermy of the angiomas, endolaser scatter photocoagulation, and scleral buckling resulted in retinal reattachment and regression of the neovascularization. Although additional surgery was necessary for recurrent tractional retinal detachment, long-term retinal reattachment and stable vision was achieved following obliteration of all angiomas. 相似文献
6.
7.
8.
9.
10.
Summary Development of third-stage larvae ofDipetalonema viteae within subcutaneously implanted micropore chambers proceeded in all hosts tested up to the fourth-stage larvae and occasionally to adolescent worms. In the jird the timing of development was comparable to a natural infection. Although the mouse is an insusceptible host, larval development could take place, but was very slow. Two intraperitoneal inoculations of living thirdstage larvae into mice induced the production of antibodies against the larval cuticle and against common antigens. In such immune mice the development of third- and fourth-stage larvae within micropore chambers was significantly inhibited, larval mortality was increased, and the larval motility was impaired. 相似文献