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GIULIO CONTE M.D. CARLO DE ASMUNDIS M.D. Ph.D. JUAN SIEIRA M.D. MOISES LEVINSTEIN M.D. GIAN‐BATTISTA CHIERCHIA M.D. GIACOMO DI GIOVANNI M.D. GIANNIS BALTOGIANNIS M.D. GIUSEPPE CICONTE M.D. YUKIO SAITOH M.D. RUBEN CASADO‐ARROYO M.D. GUDRUN PAPPAERT R.N. PEDRO BRUGADA M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2014,25(5):514-519
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AUSILIA MARIA MANGANONI M.D. CAMILO FARISOGLIO M.D. GIOVANNA TUCCI M.D. FABIO FACCHETTI M.D. † MARCO UNGARI M.D. † PIER GIACOMO CALZAVARA-PINTON M.D. 《Pediatric dermatology》2009,26(3):356-357
Abstract: Approximately, 1–4% of all new melanoma cases occur in patients younger than 20 years. The clinical presentation of melanoma in the young is often challenging. We report the experience of the Melanoma Unit of University Hospital Spedali Civili of Brescia, Italy. Study subjects were drawn from 1470 patients with histologically confirmed melanoma. From this group, melanoma developed in 12 patients younger than 19 years. For each melanoma diagnosed, histologic characteristics, treatment, and outcomes were evaluated. Of the 12 patients described in this study, four were men and eight were women. The average age was 15.6 years ranging from 11 to 18 years. Regarding invasive melanomas, Breslow thickness ranged from 0.15 to 0.66 mm with a mean thickness of 0.36 mm. Primary treatment of 12 patients included wide local excision of their primary lesions. In many cases reported in literature lesions are amelanotic, nodular, and resemble pyogenic granuloma. From our case studies it was found that the clinical characteristics detected in melanomas diagnosed in childhood and adolescence have been the same as those described in adults and that the ABCDE clinical criteria may be helpful basics of melanoma. 相似文献
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MASSIMO FRESTA GIOVANNI PUGLISI CLAUDIA DI GIACOMO ALESSANDRA RUSSO 《The Journal of pharmacy and pharmacology》1994,46(12):974-981
Abstract— Citicoline is a therapeutic agent widely used in the treatment of brain injury, for example in cerebrovascular disease or traumatic accidents. Unfortunately, the strong polar nature of this drug prevents it crossing the blood-brain barrier. In this paper, the possibility of efficiently trapping citicoline in liposomes to improve its therapeutic effects is reported. The citicoline-encapsulation efficiency, drug leakage and size analysis of various liposome systems were studied. The real therapeutic effectiveness of these citicoline liposome formulations was evaluated by biological assay. The effects of free and liposome encapsulated citicoline on survival rate of ischaemic reperfused male Wistar rats (80–100 g) were investigated. Of the phospholipid mixtures used in citicoline liposome formulation the best in terms of delivery and therapeutic effects was 1,2-dipalmitoyl-sn-glycero-phosphocholine:dipalmitoyl-dl -α-phosphatidyl-l -serine: cholesterol (7:4:7 molar ratio). This phospholipid mixture was also assayed for brain conjugated diene levels in rats, since this parameter is an index of lipid peroxidation in rat cerebral cortex during post-ischaemic reperfusion. A citicoline-loaded phospholipid mixture has produced an increase in rat survival rate of about 24% and a reduction in diene levels of 60%, compared to the free drug. 相似文献
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A. MARTINI M. S. SCOTTA L. D. NOTARANGELO G. MAGGIORE S. GUARNACCIA C. DE GIACOMO 《Acta paediatrica (Oslo, Norway : 1992)》1983,72(6):931-934
ABSTRACT. A child with an immune-mediated disease is described, who presented two very rare clinical manifestations, a membranous glomerulopathy with circulating anti-renal tubular basement membrane antibody and a small-intestinal enteropathy with circulating antibody directed against the cytoplasm of intestinal epithelial cells. Steroid treatment was followed by complete resolution of the renal but not the intestinal manifestations. 相似文献
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GIUSEPPE CICONTE M.D. JUAN SIEIRA‐MORET M.D. EBRU HACIOGLU M.D. GIACOMO MUGNAI M.D. GIACOMO DI GIOVANNI M.D. VEDRAN VELAGIC M.D. YUKIO SAITOH M.D. GIULIO CONTE M.D. Ph.D. GHAZALA IRFAN M.D. GIANNIS BALTOGIANNIS M.D. Ph.D. BURAK HUNUK M.D. ERWIN STROKER M.D. PEDRO BRUGADA M.D. Ph.D. CARLO DE ASMUNDIS M.D. Ph.D. F.H.R.S. GIAN‐BATTISTA CHIERCHIA M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2016,27(7):796-803
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MASSIMO LAZZERI GIROLAMO CALO MICHELE SPINELLI REMO GUERRINI PATRIZIA BENEFORTI SANDRO SANDRI ALBERTO ZANOLLO DOMENICO REGOLI DAMIANO TURINI 《The Journal of urology》2001,166(6):2237-2240
PURPOSE: Management of neurogenic incontinence is complex and available treatments are not satisfactory. Nociceptin/orphanin FQ, a recently discovered neuropeptide, has been reported to inhibit the voiding reflex in the rat. These experimental results prompted us to investigate the urodynamic and clinical effects of intravesical instillation of nociceptin/orphanin FQ in humans. MATERIAL AND METHODS: Our study involved 5 normal subjects (group 1) with a mean age of 40.4 years (range 21 to 54) and 9 patients (group 2) 40.4 years (24 to 54). All patients in group 2 presented with detrusor hyperreflexia refractory to standard therapy. They were invited to undergo a filling cystometrogram with saline solution and after 30 minutes, a new one with a solution containing 1 microM. nociceptin/orphanin FQ. The urodynamic parameters that were recorded included bladder capacity, volume threshold for the appearance of detrusor hyperreflexia and maximum bladder pressure. Clinical and urodynamic followup was performed after 15 days. The data were statistically analyzed with 1-way analysis of variance followed by the Dunnett test for multiple comparison considered statistically significant with p <0.05. RESULTS: Intravesical instillation of 1 microM. nociceptin/orphanin FQ in group 1 did not produce significant functional changes. This infusion in group 2 produced a statistically significant increase in mean bladder capacity and volume threshold for the appearance of detrusor hyperreflexia from 164 plus or minus standard deviation (SD) 84 to 301 +/- 118 and 93 plus or minus SD 41 to 231 +/- 104 ml. (p <0.05, respectively). Mean maximum bladder pressure decreased from 79 plus or minus SD 25 to 54 +/- 44 cm. water but was not statistically significant (p = 0.19). After 15 days an absence of clinical improvement was noticed in group 2, and the urodynamic control did not show any significant changes compared to the values before nociceptin/orphanin FQ treatment. No severe symptomatic reactions were observed during infusion of 1 microM. nociceptin/orphanin FQ. CONCLUSIONS: Our results demonstrate that nociceptin/orphanin FQ is able to elicit a robust inhibitory effect on voiding reflex in group 2 but not 1. The ideal dosage, route of administration of nociceptin/orphanin FQ and treatment interval are not yet established. 相似文献
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PALLI DOMENICO; SAIEVA CALOGERO; TRALLORI GIACOMO; BARDAZZI GABRIELE; D'ALBASIO GIUSEPPE; MILLA MONICA; GALLI MONICA; TARANTINO OTTAVIANO; PACINI FRANCO 《European journal of public health》1997,7(1):109-112
In the frame of a population-based epidemiological study inthe metropolitan area of Florence in a 15 year period (19781992)all prevalent patients affected with ulcerative colitis (UC)or Crohn's disease (CD) (alive and resident in the area at theend of the study) were investigated in order to identify familialclustering. Only 45 patients (5.2%) reported at least 1 relativewith a diagnosis of inflammatory bowel disease (IBD). Amongthese, 25 patients reported a first-degree relative affectedwith IBD (2.9%). All the 28 families were contacted and detailedpersonal interviews were carried out in order to collect familytrees. The affected relatives living outside the study areawere also identified and their IBD diagnoses were verified.Fifteen families included only affected members with a diagnosisof UC; 5 had only CD, while 8 families had members affectedwith both forms. Two large families had 4 affected members and2 other families had 3. Overall 9 parent-child affected pairswere identified (1 out of every 3 families). The high concordancewithin families for the type of disease (p=0.015) suggests thatthe disease susceptibility is specific. The authors discussthese findings and a possible interpretation of the low proportionof familial cases in this area. 相似文献