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Carlen Reyes Francesc Formiga Marta Coderch Jordi Hoyo Gemma Ferriz Jordi Casanovas Rosa Monteserín Carlos Brotons Marta Rojas Irene Moral 《BONE》2013,52(2):557-561
ObjectiveTo determine whether there is an increased risk of hip fracture associated with the use of proton pump inhibitors in a Mediterranean area after adjusting for other potential risk factors.MethodsRetrospective multicenter case–control study carried out in 6 primary health care centers in Catalonia, Spain. Cases were patients aged 50 years and over with a fragility hip fracture registered between January 2007 and December 2010, matched with 2 controls by sex and age. Data collected: use of proton pump inhibitors (type, dosage) in the 5 years previous to the hip fracture, socio-demographic data, body mass index, alcohol and tobacco consumption as well as health conditions and drugs associated with an increase risk of fragility hip fracture.Results358 cases were matched with 698 controls. The mean age was 82 years old in both groups. Women represented 77.1% in the case group and 76.9% in the control group. Crude association between proton pump inhibitors and hip fracture was 1.44 (95% CI, 1.09–1.89) and adjusted OR was 1.24 (95% CI, 0.93–1.65). No association was found with the continuous or discontinuous use of proton pump inhibitors, OR 1.17 (95% CI, 0.77–1.79), and OR of 1.16 (95% CI, 0.85–1.60) respectively. No association was found when restricting the analysis by sex, OR of 1.19 (95% CI, 0.27–5.14) or by age, younger or older than 80 years, OR of 0.72 (95% CI, 0.24–2.15).ConclusionThe use of proton pump inhibitors was not associated with an increased risk of hip fracture after adjusting for other risk factors in a Mediterranean area. This result suggests the existence of protective environmental factors linked to this southern area of Europe that eventually could compensate for the potential harm produced by proton pump inhibitors. 相似文献
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Eva Bernal Antoni Bayés-Genís Albert Ariza-Solé Francesc Formiga Maria T. Vidán Luis Alberto Escobar-Robledo Jaime Aboal Lídia Alcoberro Carme Guerrero Iván Ariza-Segovia Ana Hernández de Benito Pau Vilardell José Carlos Sánchez-Salado Victoria Lorente Antoni Bayés de Luna Manuel Martinez-Sellés 《Journal of electrocardiology》2018,51(4):747
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Early dysfunction and long-term improvement in endothelium-dependent vasodilation in the infarct-related artery after thrombolysis 总被引:37,自引:0,他引:37
Iràculis E Cequier A Gómez-Hospital JA Sabaté M Mauri J Fernández-Nofrerias E García del Blanco B Jara F Esplugas E 《Journal of the American College of Cardiology》2002,39(2):257-265
Endothelial function is thought to be an important factor in the pathogenesis of atherosclerosis, hypertension and heart failure. In the 1990s, high-frequency ultrasonographic imaging of the brachial artery to assess endothelium-dependent flow-mediated vasodilation (FMD) was developed. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function. The noninvasive nature of the technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. However, despite its widespread use, there are technical and interpretive limitations of this technique. State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology. 相似文献