全文获取类型
收费全文 | 53685篇 |
免费 | 2942篇 |
国内免费 | 168篇 |
专业分类
耳鼻咽喉 | 515篇 |
儿科学 | 1735篇 |
妇产科学 | 1096篇 |
基础医学 | 8831篇 |
口腔科学 | 593篇 |
临床医学 | 4964篇 |
内科学 | 12406篇 |
皮肤病学 | 1310篇 |
神经病学 | 4709篇 |
特种医学 | 2086篇 |
外国民族医学 | 31篇 |
外科学 | 6546篇 |
综合类 | 181篇 |
一般理论 | 6篇 |
预防医学 | 3545篇 |
眼科学 | 779篇 |
药学 | 3557篇 |
2篇 | |
中国医学 | 96篇 |
肿瘤学 | 3807篇 |
出版年
2023年 | 262篇 |
2022年 | 227篇 |
2021年 | 744篇 |
2020年 | 474篇 |
2019年 | 842篇 |
2018年 | 1443篇 |
2017年 | 1000篇 |
2016年 | 1008篇 |
2015年 | 1233篇 |
2014年 | 1368篇 |
2013年 | 2076篇 |
2012年 | 3488篇 |
2011年 | 3423篇 |
2010年 | 1791篇 |
2009年 | 1484篇 |
2008年 | 3136篇 |
2007年 | 3232篇 |
2006年 | 3003篇 |
2005年 | 3103篇 |
2004年 | 2959篇 |
2003年 | 2716篇 |
2002年 | 2658篇 |
2001年 | 1357篇 |
2000年 | 1373篇 |
1999年 | 1160篇 |
1998年 | 414篇 |
1997年 | 380篇 |
1996年 | 346篇 |
1995年 | 308篇 |
1994年 | 294篇 |
1993年 | 246篇 |
1992年 | 657篇 |
1991年 | 610篇 |
1990年 | 618篇 |
1989年 | 612篇 |
1988年 | 536篇 |
1987年 | 525篇 |
1986年 | 488篇 |
1985年 | 445篇 |
1984年 | 326篇 |
1983年 | 250篇 |
1982年 | 170篇 |
1979年 | 236篇 |
1978年 | 159篇 |
1977年 | 159篇 |
1974年 | 178篇 |
1973年 | 158篇 |
1972年 | 148篇 |
1971年 | 155篇 |
1969年 | 158篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献
2.
3.
4.
5.
Marta López-Fauqued Laura Campora Frédérique Delannois Mohamed El Idrissi Lidia Oostvogels Ferdinandus J. De Looze Javier Diez-Domingo Thomas C. Heineman Himal Lal Janet E. McElhaney Shelly A. McNeil Wilfred Yeo Fernanda Tavares-Da-Silva 《Vaccine》2019,37(18):2482-2493
Background
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.Methods
Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Safety analyses were performed on the pooled total vaccinated cohort, consisting of participants receiving at least one dose of RZV or placebo. Solicited and unsolicited adverse events (AEs) were collected for 7 and 30?days after each vaccination, respectively. Serious AEs (SAEs) were collected from the first vaccination until 12?months post-last dose. Fatal AEs, vaccination-related SAEs, and potential immune-mediated diseases (pIMDs) were collected during the entire study period.Results
Safety was evaluated in 14,645 RZV and 14,660 placebo recipients. More RZV than placebo recipients reported unsolicited AEs (50.5% versus 32.0%); the difference was driven by transient injection site and solicited systemic reactions that were generally seen in the first week post-vaccination. The occurrence of overall SAEs (RZV: 10.1%; Placebo: 10.4%), fatal AEs (RZV: 4.3%; Placebo: 4.6%), and pIMDs (RZV: 1.2%; Placebo: 1.4%) was balanced between groups. The occurrence of possible exacerbations of pIMDs was rare and similar between groups. Overall, except for the expected local and systemic symptoms, the safety results were comparable between the RZV and Placebo groups irrespective of participant age, gender, or race.Conclusions
No safety concerns arose, supporting the favorable benefit-risk profile of RZV. 相似文献6.
Frédéric Janvier Deborah Delaune Thomas Poyot Eric Valade Audrey Mérens Pierre E. Rollin Vincent Foissaud 《Emerging infectious diseases》2016,22(2):292-294
We evaluated RNA stability of Ebola virus in EDTA blood and urine samples collected from infected patients and stored in West Africa’s environmental conditions. In blood, RNA was stable for at least 18 days when initial cycle threshold values were <30, but in urine, RNA degradation occurred more quickly. 相似文献
7.
8.
9.
10.
Abdelhadi Lahoum Nasserdine Sabaou Christian Bijani Noureddine Bouras Frédéric Pont Selma P. Snini Florence Mathieu 《Saudi Pharmaceutical Journal》2019,27(1):56-65
The actinobacterium strain ABH26 closely related to Saccharothrix xinjiangensis, isolated from an Algerian Saharan soil sample, exhibited highly antagonist activity against Gram-positive bacteria, yeasts and filamentous fungi. Its ability to produce antimicrobial compounds was investigated using several solid culture media. The highest antimicrobial activity was obtained on Bennett medium. The antibiotics secreted by strain ABH26 on Bennett medium were extracted by methanol and purified by reverse-phase HPLC using a C18 column. The chemical structures of the compounds were determined after spectroscopic (1H NMR, 13C NMR, 1H-1H COSY and 1H-13C HMBC spectra), and spectrometric (mass spectrum) analyses. Two new cyanogriside antibiotics named cyanogriside I (1) and cyanogriside J (2), were characterized along with three known caerulomycins, caerulomycin A (3), caerulomycin F (4) and caerulomycinonitrile (5). This is the first report of cyanogrisides and caerulomycins production by a member of the Saccharothrix genus. The minimum inhibitory concentrations (MIC) of these antibiotics were determined against pathogenic microorganisms. 相似文献