全文获取类型
收费全文 | 16820篇 |
免费 | 1547篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 82篇 |
儿科学 | 567篇 |
妇产科学 | 424篇 |
基础医学 | 2261篇 |
口腔科学 | 225篇 |
临床医学 | 2278篇 |
内科学 | 3192篇 |
皮肤病学 | 189篇 |
神经病学 | 1475篇 |
特种医学 | 482篇 |
外国民族医学 | 5篇 |
外科学 | 1937篇 |
综合类 | 376篇 |
现状与发展 | 1篇 |
一般理论 | 37篇 |
预防医学 | 2119篇 |
眼科学 | 465篇 |
药学 | 1416篇 |
中国医学 | 13篇 |
肿瘤学 | 853篇 |
出版年
2023年 | 124篇 |
2022年 | 155篇 |
2021年 | 349篇 |
2020年 | 262篇 |
2019年 | 426篇 |
2018年 | 458篇 |
2017年 | 356篇 |
2016年 | 384篇 |
2015年 | 412篇 |
2014年 | 574篇 |
2013年 | 779篇 |
2012年 | 1118篇 |
2011年 | 1133篇 |
2010年 | 591篇 |
2009年 | 528篇 |
2008年 | 944篇 |
2007年 | 1028篇 |
2006年 | 928篇 |
2005年 | 971篇 |
2004年 | 910篇 |
2003年 | 815篇 |
2002年 | 718篇 |
2001年 | 338篇 |
2000年 | 316篇 |
1999年 | 270篇 |
1998年 | 176篇 |
1997年 | 172篇 |
1996年 | 146篇 |
1995年 | 106篇 |
1994年 | 114篇 |
1993年 | 118篇 |
1992年 | 187篇 |
1991年 | 178篇 |
1990年 | 161篇 |
1989年 | 140篇 |
1988年 | 130篇 |
1987年 | 135篇 |
1986年 | 111篇 |
1985年 | 123篇 |
1984年 | 101篇 |
1983年 | 95篇 |
1982年 | 88篇 |
1981年 | 67篇 |
1980年 | 70篇 |
1979年 | 119篇 |
1978年 | 77篇 |
1977年 | 73篇 |
1974年 | 67篇 |
1973年 | 67篇 |
1968年 | 64篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Raymond J. Chan RN PhD Vivienne E. Milch MBBS MHPol Fiona Crawford-Williams PhD Oluwaseyifunmi Andi Agbejule BRadTherapy Ria Joseph MNutrDiet Jolyn Johal BND Narayanee Dick BSc Matthew P. Wallen PhD Julie Ratcliffe PhD Anupriya Agarwal MBBS Larissa Nekhlyudov MD Matthew Tieu PhD Manaf Al-Momani BPharm Scott Turnbull PhD Rahul Sathiaraj MPH Dorothy Keefe MBBS MD Nicolas H. Hart PhD 《CA: a cancer journal for clinicians》2023,73(6):565-589
Patient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty-four reviews were quantitative or mixed-methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost-effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost-effectiveness of navigation in screening programs. 相似文献
2.
Alexandra Elliott Laura Schoenlaub Danielle Freches William Mitchell Guoquan Zhang 《Infection and immunity》2015,83(8):3104-3113
Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes the zoonotic disease Q fever. Although Q fever is mainly transmitted by aerosol infection, study of the immune responses in the lung following pulmonary C. burnetii infection is lacking. Neutrophils are considered the first immune cell to migrate into the lung and play an important role in host defense against aerosol infection with microbial pathogens. However, the role of neutrophils in the host defense against C. burnetii infection remains unclear. To determine the role of neutrophils in protective immunity against C. burnetii infection, the RB6-8C5 antibody was used to deplete neutrophils in mice before intranasal infection with C. burnetii. The results indicated that neutrophil-depleted mice developed more severe disease than their wild-type counterparts, suggesting that neutrophils play an important role in host defense against C. burnetii pulmonary infection. We also found that neither CXC chemokine receptor 2 (CXCR2) nor interleukin-17 (IL-17) receptor (IL-17R) deficiency changed the severity of disease following intranasal C. burnetii challenge, suggesting that keratinocyte-derived chemokine and IL-17 may not play essential roles in the response to C. burnetii infection. However, significantly higher C. burnetii genome copy numbers were detected in the lungs of IL-1R−/− mice at 14 days postinfection. This indicates that IL-1 may be important for the clearance of C. burnetii from the lungs following intranasal infection. Our results also suggest that neutrophils are involved in protecting vaccinated mice from C. burnetii challenge-induced disease. This is the first study to demonstrate an important role for neutrophils in protective immunity against C. burnetii infection. 相似文献
3.
4.
5.
6.
7.
8.
H L Elliott P A Meredith L Campbell J L Reid 《Clinical pharmacology and therapeutics》1988,43(5):554-560
An exaggerated fall in blood pressure has been reported with the combination of an alpha 1-blocker and a calcium antagonist. This study investigated, in a placebo-controlled, randomized crossover trial, the clinical usefulness of the combination of prazosin (2 mg b.i.d.) and verapamil (160 mg b.i.d.). Therapeutic efficacy was monitored at regular outpatient visits: average supine and erect blood pressures were, respectively, 175/99 and 176/103 mm Hg with placebo, 160/91 and 164/96 mm Hg with single drug treatment, and 152/84 and 152/89 mm Hg with combination therapy. This significant and clinically useful reduction in blood pressure had an overall magnitude of approximately 28/18 mm Hg (supine) and 29/19 mm Hg (erect). Further measurements were made during a series of intensive study days, and the most important additional finding was a pharmacokinetic interaction that resulted in increased peak concentrations and bioavailability of prazosin. In conclusion, the combination of prazosin and verapamil proved effective in the treatment of 12 patients with essential hypertension who had been poorly responsive to conventional treatment with a beta-blocker and thiazide diuretic. 相似文献
9.
10.
The development of the eye was investigated in the mouse embryo following a single administration of ethanol plus [3H]thymidine to the dam on day 13 of gestation. After 1 hr there was no difference in the number of labelled cells/100 micron 2 in the neural layer of the retina compared to controls, but there was an alcohol-related reduction in labelling density. After 24 hr there was an increase in the numbers of both pyknotic cells and mitotic figures, breaks occurred in the inner surface of the retina and cell debris was being extruded into the posterior chamber. At 48 hr the increase in pyknotic cells persisted, but there was less evidence of cell debris and the borders had been repaired. The estimated cell cycle time in the neural progenitor cells following maternal alcohol administration was increased 7-fold compared to controls. Morphometric analysis revealed that after 48 hr there were significant alcohol-related reductions in the width and depth of the eye, in the thickness of the neural layer and in the interocular distance. It appears that many of the ophthalmic abnormalities reported in human fetal alcohol syndrome can be produced in the mouse embryo following a single episode of acute maternal intoxication during a critical period of ocular ontogeny, and that they evolve primarily from disturbances in the normal patterns of recruitment and loss of neural progenitor cells in the developing retina. 相似文献