全文获取类型
收费全文 | 2312篇 |
免费 | 168篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 63篇 |
妇产科学 | 172篇 |
基础医学 | 259篇 |
口腔科学 | 75篇 |
临床医学 | 259篇 |
内科学 | 350篇 |
皮肤病学 | 68篇 |
神经病学 | 103篇 |
特种医学 | 113篇 |
外科学 | 222篇 |
综合类 | 62篇 |
一般理论 | 3篇 |
预防医学 | 256篇 |
眼科学 | 78篇 |
药学 | 161篇 |
中国医学 | 2篇 |
肿瘤学 | 239篇 |
出版年
2022年 | 21篇 |
2021年 | 33篇 |
2020年 | 19篇 |
2019年 | 36篇 |
2018年 | 39篇 |
2017年 | 30篇 |
2016年 | 34篇 |
2015年 | 28篇 |
2014年 | 66篇 |
2013年 | 76篇 |
2012年 | 90篇 |
2011年 | 124篇 |
2010年 | 74篇 |
2009年 | 80篇 |
2008年 | 77篇 |
2007年 | 116篇 |
2006年 | 107篇 |
2005年 | 101篇 |
2004年 | 100篇 |
2003年 | 90篇 |
2002年 | 71篇 |
2001年 | 41篇 |
2000年 | 38篇 |
1999年 | 52篇 |
1998年 | 59篇 |
1997年 | 41篇 |
1996年 | 33篇 |
1995年 | 29篇 |
1994年 | 27篇 |
1993年 | 26篇 |
1992年 | 29篇 |
1991年 | 37篇 |
1990年 | 34篇 |
1989年 | 42篇 |
1988年 | 25篇 |
1987年 | 38篇 |
1986年 | 22篇 |
1985年 | 22篇 |
1984年 | 24篇 |
1983年 | 29篇 |
1982年 | 27篇 |
1981年 | 32篇 |
1980年 | 28篇 |
1979年 | 27篇 |
1978年 | 23篇 |
1977年 | 22篇 |
1976年 | 29篇 |
1975年 | 25篇 |
1974年 | 23篇 |
1970年 | 20篇 |
排序方式: 共有2499条查询结果,搜索用时 15 毫秒
1.
Andy KH Lim 《World journal of gastroenterology : WJG》2020,26(10):1020-1028
Rhabdomyolysis is a syndrome of skeletal muscle injury with release of cellular constituents such as potassium,phosphate,urate and intracellular proteins such as myoglobin into the circulation,which may cause complications including acute kidney injury,electrolyte disturbance and cardiac instability.Abnormal liver function tests are frequently observed in cases of severe rhabdomyolysis.Typically,there is an increase in serum aminotransferases,namely aspartate aminotransferase and alanine aminotransferase.This raises the question of liver injury and often triggers a pathway of investigation which may lead to a liver biopsy.However,muscle can also be a source of the increased aminotransferase activity.This review discusses the dilemma of finding abnormal liver function tests in the setting of muscle injury and the potential implications of such an association.It delves into some of the clinical and experimental evidence for correlating muscle injury to raised aminotransferases,and discusses pathophysiological mechanisms such as oxidative stress which may cause actual liver injury.Serum aminotransferases lack tissue specificity to allow clinicians to distinguish primary liver injury from muscle injury.This review also explores potential approaches to improve the accuracy of our diagnostic tools,so that excessive or unnecessary liver investigations can be avoided. 相似文献
2.
3.
4.
王伏虎 《南京医科大学学报(英文版)》2002,16(2):49-64
Stroke is a debilitating disease that affects millions each year.While in many cases cerebral ischemic in jury can be limited by effectivw resuscitation or thrombolytic treatment,the injured neurons wither in a process known as delayed neuronal death(DND).Mounting evidence indicates that DND is not simply necrosis played out in slow motion but apoptosis is triggered.Of particular interest are two groups of signal proteins that participate in apoptosis-cyclin dependent kinases(CDKs) and p53-among a myriad of signaling events after an ischemic insult.Recent investigations have shown that CDKs,a family of enzymes initially known for their role in cell cycle regulation,are activated in injured neurons in DND.As for p53,new reports suggest that its up-regulation may represent a failed attempt to rescue in jured neurons,although its up-regulation was previously considered an indication of apoptosis.These observations thus rekindle an old quest to identify new neuroprotective targets to minimize the stroke damage.In this review,the author will examine the evidence that indicates the participation of CDKs and p53 in DND and then introduce pre-clinical data to explore CDK inhibition as a potential neuroprotective target.Finally,using CDK inhibition as an example,this paper will discuss the pertinent criteria for a viable neuroprotective strategy for ischemic in jury. 相似文献
5.
6.
André H. Eriksson Manthena V.S. Varma Everett J. Perkins Cheryl L. Zimmerman 《Journal of pharmaceutical sciences》2010,99(3):1574-1581
LY354740 is a potent mGlu2/3 agonist with a limited oral bioavailability. Its alanyl prodrug, LY544344, showed high affinity to the intestinal peptide transporter PEPT1, and improved the oral bioavailability of LY354740 in various animal models. The aim of the present study was to investigate the mechanism of in vivo absorption of the dipeptidic prodrug LY544344. The permeabilities of LY544344 and LY354740 were examined in the rat in situ single‐pass intestinal perfusion model. The intestinal absorptive flux of LY354740 was shown to be very low in comparison with LY544344. The absorptive flux of LY544344 could best be described by a Michaelis–Menten process in parallel with a linear process. The estimated parameters were: Jmax = 26.7 × 10?5 µmol/(cm2‐s), Km = 2.6 mM. The absorptive permeability of LY544344 was reduced to approximately 5% of control in the presence of excess Gly‐Sar, a known PEPT1 substrate. Intracellular accumulation of LY354740 and LY544344, estimated postperfusion, showed high levels of LY354740 over LY544344 at all perfusate concentrations studied. However, there was a decline in the intracellular ratio of LY354740 to LY544344 at higher concentrations, suggesting that the metabolic activation to release LY354740 is saturable. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1574–1581, 2010 相似文献
7.
8.
Over a period of years the ventilation system of a community hospital progressively deteriorated until it no longer met regulatory guidelines. The hospital, a publicly funded military facility, requested funding to repair the ventilation system, but funds were not forthcoming because of budget austerity. When an increase in infections was documented, high-risk operations were curtailed and funding was expedited. With the new improved ventilation system the operating rooms once again met regulatory guidelines and infections returned to baseline rates. Throughout the period infections remained below recognized national levels. 相似文献
9.
10.