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排序方式: 共有2354条查询结果,搜索用时 15 毫秒
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Angelo M. Carella Sandro Nati Paolo Carlier Daniela Pierluigi Domenico Giordano Angela Congiu Gino Santini Daniele Scarpati Salvina Barra Renzo Corvo Vito Vitale Maria R. Raffo Raffaella Cerri Marco Risso Mauro Spriano Renato Vimercati Ester Pungolino Andrea Bacigalupo Eugenio Damasio 《Leukemia & lymphoma》1991,5(1):43-47
Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT.
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
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V V Abramov 《Vestnik Rossi?sko? akademii meditsinskikh nauk / Rossi?skaia akademiia meditsinskikh nauk》1992,(11-12):39-44
Exposure to adverse environmental factors can result in the impaired relationships between the immune and nervous systems and hence increase autonomic properties of immunocompetent cells. This impairment may underlie some diseases associated with abnormal immunity. To have knowledge on the ways of restoring the integrative connections between the above systems will help maintain human health, augment its potential as a creator of the noosphere. 相似文献
6.
Debora Steiner Tomer Avidor-Reiss Ester Schallmach Daniella Saya Zvi Vogel 《Journal of molecular neuroscience : MN》1996,27(2):195-203
It was shown previously that chronic exposure to opiate agonists increases adenylyl cyclase (AC) activity, a phenomenon termed
AC superactivation (or supersensitization). More recently, we showed that acute Gi/o-coupled receptor activation inhibits the activity of several AC isozymes, including Ca2+/calmodulin-stimulated AC-I and -VIII, whereas chronic receptor activation induces their superactivation. Here, we report
that both acute μ-opioid receptor-induced inhibition and chronic induced superactivation of AC-I and -VIII are pertussis toxin
sensitive. In addition, we show that proteins that interfere with the activity of {ie195-2} subunits ({ie195-3} scavengers)
strongly attenuate the acute inhibition of AC-I and -VIII and the superactivation of AC-I, and abolish the superactivation
of AC-VIII. Based on these results, we suggest that {ie195-4} is involved in the acute inhibition and chronic agonist-induced
superactivation of AC types I and VIII. 相似文献
7.
Helen He Ester Del Duca Aisleen Diaz Hyun Je Kim Jesús Gay-Mimbrera Ning Zhang Jianni Wu Jessica Beaziz Yeriel Estrada James G. Krueger Ana B. Pavel Juan Ruano Emma Guttman-Yassky 《The Journal of allergy and clinical immunology》2021,147(4):1369-1380
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8.
S. S. Pertsov V. M. Abramov A. S. Sosnovskii G. V. Pirogova A. A. Kubatiev 《Bulletin of experimental biology and medicine》1994,117(3):238-240
Acute emotional stress results in damage to gastric mucous membranes in August, Wag, and particularly Wistar rats. The damage
is less severe in rats preinjected with inter-leukin 1β into a lateral ventricle of the cerebrum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
3, pp. 238–239, March, 1994 相似文献
9.
Yu. M. Kolesnik Yu. N. Orestenko A. V. Abramov 《Neuroscience and behavioral physiology》1994,24(2):163-166
1. | A close interdependence is observed in experimental diabetes mellitus on the state of the endocrine portion of the pancreas and on neurosecretory nuclei of the hypothalamus that synthesize vasopressin, oxytocin, and corticoliberin. |
2. | The activation of the vasopressin-, corticoliberin-, and oxytocin-synthesizing neurons of the subnuclei of the PVNH and the SONH is accompanied, according to the data of morphohistochemical investigations by an increase in the blood of the concentration of vasopressin, corticoliberin, ACTH, and cortisone, as well as of oxytocin in the median eminence of the hypothalamus. |
10.
Donnadieu E Jouvin MH Rana S Moffatt MF Mockford EH Cookson WO Kinet JP 《Immunity》2003,18(5):665-674
Allergic reactions are triggered via crosslinking of the high-affinity receptor for immunoglobulin E, F(c)epsilonRI. In humans, F(c)epsilonRI is expressed as a tetramer (alphabetagamma(2)) and a trimer (alphagamma(2)). The beta subunit is an amplifier of F(c)epsilonRI surface expression and signaling. Here, we show that as a consequence of alternative splicing, the F(c)epsilonRIbeta gene encodes two proteins with opposing and competing functions. One isoform is the full-length classical beta, the other a novel truncated form, beta(T). In contrast to beta, beta(T) prevents F(c)epsilonRI surface expression by inhibiting alpha chain maturation. Moreover, beta(T) competes with beta to control F(c)epsilonRI surface expression in vitro. We propose that the relative abundance of the products of the beta gene may control the level of F(c)epsilonRI surface expression and thereby influence susceptibility to allergic diseases. 相似文献