全文获取类型
收费全文 | 216篇 |
免费 | 27篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 3篇 |
妇产科学 | 6篇 |
基础医学 | 21篇 |
口腔科学 | 9篇 |
临床医学 | 20篇 |
内科学 | 54篇 |
皮肤病学 | 10篇 |
神经病学 | 8篇 |
特种医学 | 8篇 |
外科学 | 42篇 |
综合类 | 11篇 |
预防医学 | 7篇 |
眼科学 | 7篇 |
药学 | 25篇 |
中国医学 | 2篇 |
肿瘤学 | 7篇 |
出版年
2024年 | 1篇 |
2023年 | 9篇 |
2022年 | 7篇 |
2021年 | 11篇 |
2020年 | 11篇 |
2019年 | 14篇 |
2018年 | 44篇 |
2017年 | 29篇 |
2016年 | 5篇 |
2015年 | 6篇 |
2014年 | 13篇 |
2013年 | 14篇 |
2012年 | 15篇 |
2011年 | 12篇 |
2010年 | 6篇 |
2009年 | 4篇 |
2008年 | 5篇 |
2007年 | 1篇 |
2006年 | 2篇 |
2005年 | 5篇 |
2003年 | 2篇 |
2002年 | 3篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1992年 | 1篇 |
1986年 | 1篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1966年 | 1篇 |
1948年 | 1篇 |
1932年 | 1篇 |
排序方式: 共有243条查询结果,搜索用时 15 毫秒
1.
Ghoreifi Alireza Basin Michael F. Ghodoussipour Saum Bazargani Soroush T. Amini Erfan Aslzare Mohammad Cai Jie Miranda Gus Sugeir Shihab Bhanvadia Sumeet Schuckman Anne K. Daneshmand Siamak Lumb Philip Djaladat Hooman 《International urology and nephrology》2021,53(9):1827-1833
International Urology and Nephrology - The aim of this study is to evaluate the intra/perioperative fluid management and early postoperative outcomes of patients who underwent radical cystectomy... 相似文献
2.
Gamze Erfan Yakup Albayrak M. Emin Yanik Ozden Oksuz Kaan Tasolar Birol Topcu Cuneyt Unsal 《The Journal of dermatology》2014,41(8):709-715
Alopecia areata (AA) and vitiligo (V) are diseases that are correlated with psychiatric disorders before, during and after diagnosis. The Temperament and Character Inventory (TCI) is a well‐established approach for investigating personality traits in various psychosomatic diseases. The aim of this study is to compare and investigate the differences in the TCI between patients with first onset AA, patients with V and healthy controls (HC). Participants in the study included 42 patients with first onset AA, 50 adult patients with V and 60 HC who had no history or diagnoses of psychiatric or dermatological disorders. All participants were assessed with the TCI and the Dermatology Life Quality Index (DLQI). Among the temperament traits, the extravagance, disorderliness and total novelty‐seeking scores were lower, and the worry and pessimism scores were higher in patients with V compared with patients with AA and the HC. The mean score of the enlightened second nature and the total self‐directedness score of the character traits were higher in patients with V compared with patients with AA and the HC group. In the AA group, there was a negative correlation only between the reward dependence total score and the DLQI score. This study suggests that patients with first onset V have a distinct temperament, such as being unenthusiastic and unemotional, and character profiles, such as worry and pessimism, independent of their psychiatric comorbidities, and patients with AA do not have a different personality from the non‐affected population. 相似文献
3.
4.
Prospective evaluation of chronic organ damage in adult sickle cell patients: A seven‐year follow‐up study
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Charlotte F. J. van Tuijn Marein Schimmel Eduard J. van Beers Erfan Nur Bart J. Biemond 《American journal of hematology》2017,92(10):E584-E590
Organ damage in sickle cell disease (SCD) is a crucial determinant for disease severity and prognosis. In a previous study, we analyzed the prevalence of SCD‐related organ damage and complications in adult sickle cell patients. We now describe a seven‐year follow‐up of this cohort.All patients from the primary analysis in 2006 (n = 104), were included for follow‐up. Patients were screened for SCD‐related organ damage and complications (microalbuminuria, renal failure, elevated tricuspid regurgitation flow velocity (TRV) (≥2.5 m/seconds), retinopathy, iron overload, cholelithiasis, avascular osteonecrosis, leg ulcers, acute chest syndrome (ACS), stroke, priapism and admissions for vaso‐occlusive crises (VOC) biannually. Upon 7 years of follow‐up, progression in the prevalence of avascular osteonecrosis (from 12.5% to 20.4%), renal failure (from 6.7% to 23.4%), retinopathy (from 39.7% to 53.8%) was observed in the whole group. In HbSS/HbSβ0‐thal patients also progression in microalbuminuria (from 34% to 45%) and elevated TRV (from 40% to 48%) was observed while hardly any progression in the prevalence of cholelithiasis, priapism, stroke or chronic ulcers was seen. The proportion of patients with at least one episode of ACS increased in the group of HbSS/HbSβ0‐thal patients from 32% to 49.1%. In conclusion, 62% of the sickle cell patients in this prospective cohort study developed a new SCD‐related complication in a comprehensive care setting within 7 years of follow‐up. Although the hospital admission rate for VOC remained stable, multiple forms of organ damage increased substantially. These observations underline the need for continued screening for organ damage in all adult patients with SCD. 相似文献
5.
Melzer H Fortugno P Mansouri E Felici F Marinets A Wiedermann G Kollaritsch H Von Specht BU Duchêne M 《Parasite immunology》2002,24(6):321-328
Entamoeba histolytica is the protozoan parasite responsible for intestinal amoebiasis and amoebic liver abscess, which cause significant morbidity and mortality in many countries of the world. Proteophosphoglycans (PPGs, also known as lipophosphoglycans, LPGs, or lipopeptidophosphoglycans, LPPGs) represent dominant surface components of E. histolytica. Passive immunization with a monoclonal antibody (EH5) directed against these components protected SCID mice from amoebic liver abscess, so PPGs might be regarded as vaccine candidates; however, their structure is very complex and only known in part. They are glycosylphosphatidylinositol-linked polypeptides of unknown sequence carrying glycan side-chains linked to serine residues via phosphodiester bonds. In order to identify peptide mimics of the E. histolytica PPG antigens, we screened six different phage-displayed random peptide libraries with the antibody EH5. Various peptide mimics of different length were identified and, in all the peptides, a distinct consensus sequence Gly-Thr-His-Pro-X-Leu could be identified. The phages strongly bound to the antibody, and the natural antigen inhibited binding of the phages to antibody EH5. In addition, several of the phages induced a significant immunoglobulin G response against amoebic antigens in immunized mice. 相似文献
6.
7.
8.
9.
Exercise tolerance,lung function abnormalities,anemia, and cardiothoracic ratio in sickle cell patients
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eduard J. van Beers Mart N. van der Plas Erfan Nur Harm‐Jan Bogaard Reindert P. van Steenwijk Bart J. Biemond Paul Bresser 《American journal of hematology》2014,89(8):819-824
Many patients with sickle cell disease (SCD) have a reduced exercise capacity and abnormal lung function. Cardiopulmonary exercise testing (CPET) can identify causes of exercise limitation. Forty‐four consecutive SCD patients (27 HbSS, 11 HbSC, and 6 HbS‐beta thalassemia) with a median age (interquartile range) of 26 (21–41) years underwent pulmonary function tests, CPET, chest x‐ray, and echocardiography to further characterize exercise limitation in SCD. Peak oxygen uptake (V′O2‐peak), expressing maximum exercise capacity, was decreased in 83% of the studied patients. V′O2‐peak correlated with hemoglobin levels (R = 0.440, P = 0.005), forced vital capacity (FVC) (R = 0.717, P < 0.0001). Cardiothoracic ratio on chest x‐ray inversely correlated with FVC (R = ?0.637, P < 0.001). According to criteria for exercise limitation, the patients were limited in exercise capacity due to anemia (n = 17), cardiovascular dysfunction (n = 2), musculoskeletal function (n = 10), pulmonary ventilatory abnormalities (n = 1), pulmonary vascular exercise limitation (n = 1), and poor effort (n = 3). In the present study we demonstrate that anemia is the most important determinant of reduced exercise tolerance observed in SCD patients without signs of pulmonary hypertension. We found a strong correlation between various parameters of lung volume and cardiothoracic ratio and we hypothesize that cardiomegaly and relative small chest size may be important causes of the impairment in pulmonary function, that is, reduced long volumes and diffusion capacity, in SCD. Taking into account anthropomorphic differences between SCD patients and controls could help to interpret lung function studies in SCD better. Am. J. Hematol. 89:819–824, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
10.
目的:观察大鼠烟雾吸入伤后血浆及支气管肺泡灌洗液(BALF)中内皮素。1(ET-1)含量的动态变化,以探讨其与急性吸入性肺损伤发生发展的关系。方法:采用大鼠烟雾吸入伤模型,分别检测了正常对照及致伤2、6、12和24小时动物的动脉血气、肺水量、静态肺顺应性(Cst)、BALF中总蛋白(TP和白蛋白(Alb)、以及血浆和BAIF中ET-1量。结果:动物吸入伤后出现急性呼吸衰竭和严重肺水肿,Cst显著降低,BAIF中TP及Alb进行性升高;血浆及BALF中ET-1水平亦明显增加,且血浆ET-1的变化与Cst及BALF中TP的改变相关显著。结论:ET-1在烟雾吸入伤后肺血管通透性增加和肺功能损害中可能有重要作用。 相似文献