全文获取类型
收费全文 | 717篇 |
免费 | 27篇 |
国内免费 | 11篇 |
专业分类
儿科学 | 36篇 |
妇产科学 | 8篇 |
基础医学 | 43篇 |
口腔科学 | 14篇 |
临床医学 | 74篇 |
内科学 | 169篇 |
神经病学 | 28篇 |
特种医学 | 116篇 |
外科学 | 130篇 |
综合类 | 6篇 |
预防医学 | 25篇 |
药学 | 24篇 |
中国医学 | 2篇 |
肿瘤学 | 80篇 |
出版年
2023年 | 3篇 |
2022年 | 7篇 |
2021年 | 15篇 |
2020年 | 6篇 |
2019年 | 21篇 |
2018年 | 19篇 |
2017年 | 9篇 |
2016年 | 13篇 |
2015年 | 11篇 |
2014年 | 21篇 |
2013年 | 30篇 |
2012年 | 24篇 |
2011年 | 35篇 |
2010年 | 38篇 |
2009年 | 24篇 |
2008年 | 29篇 |
2007年 | 31篇 |
2006年 | 31篇 |
2005年 | 26篇 |
2004年 | 31篇 |
2003年 | 26篇 |
2002年 | 26篇 |
2001年 | 24篇 |
2000年 | 31篇 |
1999年 | 33篇 |
1998年 | 14篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 12篇 |
1994年 | 12篇 |
1993年 | 6篇 |
1992年 | 17篇 |
1991年 | 16篇 |
1990年 | 23篇 |
1989年 | 11篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1969年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有755条查询结果,搜索用时 46 毫秒
1.
2.
3.
Douglas P. Slakey James S. George Edwin Anderson Donna Willeumier Kelly Guglielmi 《American journal of surgery》2021,221(3):598-601
BackgroundEfforts to improve surgical safety are limited by several factors and no consensus exists regarding the most effective way to improve surgical quality. The use of ISO 9001 quality standards within healthcare is recognized but has not been widely applied for improving surgical outcomes.MethodsA surgical quality committee was created using ISO 9001:2015 standards. Quality objectives were assessed to understand how any suggested changes will be impacted due to risks and opportunities inherent in the system.ResultsThe initial quality focus was on surgical site infections in 5 services. Change in surgical infection ratio from 2018 to 2019 showed significant improvement: coronary bypass 1.288 vs. 0.901; Colon 1.359 vs. 0.589; Hysterectomy 2.119 vs. 1.022; Knee 1.391 vs. 0.306; Hip 0 vs. 0.302.ConclusionsThis is one of the first studies using ISO 9001 to improve surgical quality. The results indicate both acceptance and success of applying continual improvement strategies. 相似文献
4.
Digital film viewer versus conventional view boxes in the identification of bone and joint disorders
Magarelli N Guglielmi G Dragani M Mattei PA Mattioli MG Sforza Riario A 《La Radiologia medica》1999,98(4):242-247
PURPOSE: To compare the diagnostic accuracy of a digital film viewer (Smartlight 2000 Plus) versus a conventional view box for the identification of bone and joint disorders. MATERIAL AND METHODS: In order to evaluate the qualitative and quantitative differences of digital and conventional film viewers, 100 plain films of patients with bone and joint disorders taken in an emergency room January through May 1998 were reviewed utilizing both types of view boxes. Three radiologists expert of bone and joint disorders, independently compared the films, filled a form about the qualitative and quantitative analysis of the lesions depicted for each patient, and reported a few notes on the technical quality of the plain films in terms of exposure. The results were compared using the chi-square test (p < 0.005). RESULTS: Data analysis showed that the digital film viewer permitted a quicker reading of the film while decreasing the perception threshold for elementary lesions and ocular fatigue. All the radiographs read with the digital film viewer were considered technically adequate: the film quality was considered good in 10 cases and sufficient in 2. Two of the same radiographs read with the conventional view box were considered of good quality, nine were considered sufficient and one was considered insufficient due to overexposure. There were six cases of agreement and six of disagreement for the diagnosis: four were due to overexposure of the radiograph and two to better conspicuity provided by the digital film viewer. DISCUSSION: Correct image illumination is the first element a radiologist evaluates when reading a radiograph. A conventional view box may, when it is not properly maintained or when the radiograph is overexposed, decrease the radiologist's visual capacity. This increases the time required to read the radiograph and, therefore, physical and ocular fatigue, which in turn increases the risk of missing or misevaluating a lesion. A digital film viewer emits light with a variable intensity which is proportional to the optical density of the film. This increases the visual capacity of the radiologist and the lesion contrast, while reducing the factors which affect the radiograph reading. CONCLUSIONS: The use of a digital film viewer increased the visual capacity of the radiologist and eliminated the negative elements which complicated the radiograph reading and permitted the use of radiographs that would otherwise have been considered of poor quality due to overexposure. This, combined with the experience of the radiologist, decreased of the risk of missing or misevaluating a lesion. 相似文献
5.
Endovascular treatment of multiple intracranial aneurysms by using Guglielmi detachable coils 总被引:24,自引:0,他引:24
Solander S Ulhoa A Viñuela F Duckwiler GR Gobin YP Martin NA Frazee JG Guglielmi G 《Journal of neurosurgery》1999,90(5):857-864
OBJECT: The purpose of this paper is to present the authors' experience with Guglielmi detachable coil (GDC) embolization of multiple intracranial aneurysms and to evaluate the results of this therapy in single-stage procedures. METHODS: Clinical and angiographic evaluations were performed in 38 consecutive patients with multiple intracranial aneurysms treated by GDC embolization between March 1990 and October 1997. Twenty-nine patients presented with subarachnoid hemorrhage (SAH), four with mass effect, and five were asymptomatic. These 38 patients harbored 101 aneurysms, 79 of which were treated with GDCs, 14 by surgical clipping, and eight were left untreated. Of the GDC-treated lesions, a complete endovascular occlusion was achieved in 55 aneurysms (70%), and 24 (30%) presented neck remnants. Twenty-five patients (66%) underwent GDC embolization of more than one aneurysm in the first session. Eighteen (86%) of 21 patients with acute SAH underwent treatment for all aneurysms within 3 days after admission (15 of 21 in one session). Follow-up angiographic studies in 30 patients demonstrated an unchanged or improved result in 94% of the aneurysms (59 lesions) and coil compaction in 6% (four lesions). The overall clinical outcome was excellent in 34 patients (89%), good in one (3%), fair in one (3%), and death in two (5%). CONCLUSIONS: Endovascular treatment of multiple intracranial aneurysms, regardless of their location, with GDCs was performed safely in one session, even during the acute phase of SAH. Treatment of all aneurysms in one session protected the patient from rebleeding and eliminated the risk of mistakenly treating only the unruptured aneurysms. 相似文献
6.
Rodella L Catalano F Kind R Lombardo F De Manzoni G Guglielmi A 《Minerva chirurgica》1999,54(10):669-676
The Mallory-Weiss (M-W) syndrome is responsible for about 7.5% of all bleedings of oesophageal origin. Emergency endoscopic treatment allows to obtain a rapid diagnosis as well as an effective treatment. Personal experience on 160 cases of M-W tears (14.2% of all oesophageal bleeding) is reported. The tears were classified in three groups: IA and IB (30 cases); IIA and IIB (48 cases); IIC and III (82 cases). In the first two groups a complete haemostasis was obtained in 73 out of 78 cases (93.6%) with a single session and in 5/78 cases with two sessions of sclerotherapy. The third group was treated with medical therapy. There was no procedure related mortality. An analysis of etiologic factors, anatomic conditions and pathogenetic correlations has highlighted the role of portal hypertension in cirrhotic patients in favouring the bleeding in some of these patients and the role of hiatal hernia and cardial incontinence in determining the site of the lesions. 相似文献
7.
F. Brugnone L. Perbellini G. Maranelli L. Romeo G. Guglielmi F. Lombardini 《International archives of occupational and environmental health》1992,64(3):179-184
Blood benzene was determined by gas chromatography-mass spectrometry in 431 "normal" subjects, subdivided into 155 rural subjects and 276 urban subjects. Blood benzene (mean value 262 ng/l) was significantly lower in rural (200 ng/l) than in urban (296 ng/l) workers, as well as differing significantly between 293 non-smokers and 138 smokers (205 ng/l and 381 ng/l, respectively). Among non-smokers, values were significantly higher (307 ng/l) in 76 chemical workers. In the total study population, in 95% of cases blood benzene was less than 718 ng/l, the 95th percentile being 514 ng/l in non-smokers vs 901 ng/l in smokers and 576 ng/l in rural vs 822 ng/l in urban subjects. Within each population subgroup, the difference between non-smokers and smokers was statistically significant, except among office workers (non-smokers 234 ng/l, smokers 304 ng/l). Blood benzene (y) was directly proportional to the number of cigarettes smoked (x) (y = 201 + 12x; r = 0.44; n = 431), and inversely proportional to the interval between the last cigarette and the time at which the blood samples was taken (z) (log y = 6.167-0.0015z; r = -0.461; n = 135). The blood half-life of benzene was about 8h. The multiple correlation between blood benzene (Cb), number of cigarettes per day (x) and time since the last cigarette (z) is: Cb = 417 + 7.2x - 0.41z (n = 135; R = 0.20; P less than 0.00001). 相似文献
8.
Michele Baccarani Giovanna Corbelli Sante Tura S. Tura G. Corbelli M. Fiacchini M. Gobbi L. Gugliotta F. Lauria P. Ricci A. Zaccaria M. Baccarani F. Mandelli G. Alimena G. Papa L. Annino G. Guglielmi A. Allegra 《Leukemia research》1981,5(2):149-157
The effect of early splenectomy and of polychemotherapy with hydroxyurea, busulfan, and alternate bimonthly courses of arabinosyl cytosine and vincristine plus prednisone, was evaluated in 139 previously untreated patients with chronic myeloid leukemia (CML), consecutively admitted to 18 hospitals from March 1973 to October 1974. Fifty-six patients were splenectomized and 83 patients were not splenectomized. Splenectomy did not influence the duration of chronic and blastic phase, and did not prolong survival. The prognosis of high risk patients was not improved. During the chronic phase, high platelet counts were more frequent in splenectomy group, and five patients developed thrombotic or thromboembolic complications, 5 to 19 months after the operation. The median survival of the whole group was 50 months, with 32 of 139 patients (actuarial proportion 30%) remaining alive 72 months after diagnosis, but the slope of the survival curve was similar to that of historical controls. The results of this trial suggests that new strategies should be developed for the therapy of CML. 相似文献
9.
10.
Maria Elena Di Battista Esterina Pascale Carlo Purcaro Francesca Passarelli Emanuela Passarelli Renzo Guglielmi Nicola Vanacore Giuseppe Meco 《Journal of neural transmission (Vienna, Austria : 1996)》2014,121(4):353-356
The H1 haplotype of the MAPT gene influences the risk of PD and has been related to the development of PDD. We evaluated the influence of MAPT haplotypes on the expression of motor features in PD patients. We genotyped, for the MAPT haplotypes H1 and H2, a sample of 181 PD patients with distinct clinical subtypes: tremor dominant and non-tremor dominant (NTD). Our results indicate that the MAPT haplotypes contribute to the expression of motor features of PD. H1 homozygous PD patients are significantly more likely to present a NTD phenotype, a clinical subtype characterized by widespread pathological degeneration, than H2 carriers. 相似文献