全文获取类型
收费全文 | 1621篇 |
免费 | 116篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 58篇 |
妇产科学 | 36篇 |
基础医学 | 221篇 |
口腔科学 | 7篇 |
临床医学 | 105篇 |
内科学 | 476篇 |
皮肤病学 | 39篇 |
神经病学 | 89篇 |
特种医学 | 58篇 |
外国民族医学 | 1篇 |
外科学 | 198篇 |
综合类 | 12篇 |
预防医学 | 233篇 |
眼科学 | 20篇 |
药学 | 93篇 |
中国医学 | 1篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 9篇 |
2022年 | 17篇 |
2021年 | 48篇 |
2020年 | 27篇 |
2019年 | 45篇 |
2018年 | 55篇 |
2017年 | 26篇 |
2016年 | 33篇 |
2015年 | 30篇 |
2014年 | 44篇 |
2013年 | 69篇 |
2012年 | 92篇 |
2011年 | 99篇 |
2010年 | 59篇 |
2009年 | 64篇 |
2008年 | 106篇 |
2007年 | 98篇 |
2006年 | 99篇 |
2005年 | 108篇 |
2004年 | 74篇 |
2003年 | 63篇 |
2002年 | 67篇 |
2001年 | 46篇 |
2000年 | 40篇 |
1999年 | 34篇 |
1998年 | 14篇 |
1997年 | 12篇 |
1996年 | 13篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1992年 | 20篇 |
1991年 | 10篇 |
1990年 | 13篇 |
1989年 | 8篇 |
1988年 | 12篇 |
1987年 | 14篇 |
1986年 | 14篇 |
1985年 | 10篇 |
1984年 | 11篇 |
1983年 | 9篇 |
1982年 | 7篇 |
1980年 | 10篇 |
1979年 | 13篇 |
1977年 | 5篇 |
1976年 | 10篇 |
1975年 | 9篇 |
1974年 | 10篇 |
1973年 | 10篇 |
1972年 | 11篇 |
1971年 | 6篇 |
排序方式: 共有1742条查询结果,搜索用时 31 毫秒
1.
Tormo Nuria Giménez Estela Martínez-Navarro María Albert Eliseo Navalpotro David Torres Ignacio Gimeno Concepción Navarro David 《European journal of clinical microbiology & infectious diseases》2022,41(4):657-662
European Journal of Clinical Microbiology & Infectious Diseases - We compared the performance of an in-house-developed flow cytometry assay for intracellular cytokine staining (FC-ICS) and a... 相似文献
2.
Kristina W. Whitworth Brenda Berumen-Flucker George L. Delclos Sonia Fragoso Claudia Mata David Gimeno Ruiz de Porras 《Archives of environmental & occupational health》2020,75(2):70-74
AbstractThe occupational hazards and respiratory symptoms of domestic cleaners in USA are largely unknown. We conducted a cross-sectional study among 56 Hispanic female domestic cleaner on their health status and frequency of cleaning products used and tasks performed. While women used multi-use products (60.0%) and toilet bowl cleaners (51.8%) most days of the week, many (39.3%) reported not using personal protective equipment while cleaning. Itchy/watery eyes (61.8%) and itchy nose (56.4%) were the most frequently reported symptoms. A history of physician-diagnosed asthma was reported by 14.3% while 33.9% had symptoms of bronchial hyperresponsiveness (BHR). In conclusion, this vulnerable population has high prevalence of physician-diagnosis asthma and BHR symptoms and is potentially exposed to myriad occupational hazards. Further research exploring associations between products use, cleaning tasks and respiratory symptoms is warranted. 相似文献
3.
Total respiratory resistance (Rrs) was measured by the application of a sine wave of airflow to the mouth at an oscillation frequency of 10 Hz. The instrument used was the Siemens Siregnost FD5. The Rrs data were correlated with height, age, sex, and weight in 73 patients and 29 healthy subjects. The patients took part in a rehabilitation program for restoration of their locomotion function. Both groups had normal lung function (VC, FEV1) and no signs of pulmonary disease. The only important determining factor for the value of the Rrs was height. The mean Rrs of 102 subjects was 0.29 +/- 0.08 kPa.1-1.s. Other studies gave values between 0.23 +/- 0.05 and 0.32 +/- 0.10 kPa.1-1.s. 相似文献
4.
Antonio Z Gimeno‐García Adolfo Parra‐Blanco David Nicols‐Prez Cipriano Manzano‐Sanz Rafael Mndez‐Medina Enrique Quintero 《Digestive endoscopy》2006,18(2):144-146
Gastric mucormycosis involvement is a rare condition that usually occurs in inmunocompromised patients and frequently has a fatal outcome. We report the case of a 73‐year‐old woman admitted to the intensive care unit with severe bleeding after an acute pulmonary disease. Upper endoscopy disclosed wide and deep necrotic ulcers in the body and fundus of the stomach and greenish exudates with the antrum and the duodenum undamaged. Autopsy revealed an invasive mucormycosis and a severe atheromatosis. Several predisposing factors for mucormycosis infection have been reported until now. We postulate that ischemic gastritis could be a predisposing factor for colonization of zygomycete. 相似文献
5.
6.
7.
Teresa Sagalés Victor Gimeno M. Dolores de la Calzada Francesc Casellas M. Dolors Macià M. Villar Soriano 《Brain topography》1990,2(3):221-228
Summary Topographical analysis of cerebral electrical activity was performed in 44 patients with hepatic encephalopathy. These patients were classified in 5 groups according to clinical criteria. Eight healthy subjects were used as a control group. All were studied in an awake, eyes closed, condition and some [Control Group (CG), Group 0 (G0), Group 1 (G1) and Group 2 (G2)] also in an awake, eyes open, condition. The awake, eyes closed, maps showed marked differences in the power spectral density (PSD) of the different bands, when comparing normal subjects with patients with several degrees of hepatic encephalopathy. These differences were related to the degree of clinical involvement, mainly in the alpha and delta PSD bands. The combination of a decreased alpha PSD, increased delta PSD, and decreased mean dominant frequency (MDF) allowed a clear discrimination between the different clinical groups. The differences observed between awake, eyes closed, and awake, eyes open, conditions were especially helpful to discriminate between CG subjects and G0, G1 and G2 patients. 相似文献
8.
Marek’s disease virus (MDV), a highly cell-associated oncogenic chicken herpesvirus, causes Marek’s disease in domestic chickens. A unique phosphoprotein of MDV, pp38, has previously been associated with the maintenance of transformation in MDV-induced tumor cell lines. However, recently, the biological properties of a deletion mutant virus (rMd5Δpp38) revealed that pp38 is involved in early cytolytic infection in lymphocytes but not in the induction of tumors. Thus, pp38 is important for early cytolytic infection and not for transformation. The pp38 protein of the MDV serotype 1 vaccine strain CVI988/Rispens differs by one amino acid when compared to the pathogenic strains of MDV. Monoclonal antibody, H19, recognizes all serotype 1 MDV strains except CVI988/Rispens. Previous studies have also shown that the unique pp38 epitope in CVI988/Rispens induced high antibody response. In order to study the role of this epitope in the protective properties of CVI988/Rispens, we generated a mutant rMd5 virus in which the wild type pp38 gene has been substituted with that of CVI988/Rispens (rMd5/pp38CVI). The replication properties of rMd5/pp38CVI, both in vitro and in vivo, and tumor induction were examined. We found that the biological properties of rMd5/pp38CVI were similar to the wild type rMd5 virus with regards to in vivo replication, antibody response and tumor induction. This shows that the pp38 derived from CVI988/Rispens is not involved in protective properties as was previously suggested. 相似文献
9.
10.
Carlos Solano Lourdes Vázquez Estela Giménez Rafael de la Cámara Eliseo Albert Montserrat Rovira Ildefonso Espigado Carmen M. Calvo Javier López-Jiménez María Suárez-Lledó Anabella Chinea Albert Esquirol Ariadna Pérez Aránzazu Bermúdez Raquel Saldaña Inmaculada Heras Ana J. González-Huerta Tamara Torrado Guiomar Bautista Montserrat Batlle Santiago Jiménez Carlos Vallejo Pere Barba María Á. Cuesta José L. Piñana David Navarro 《American journal of transplantation》2021,21(1):258-271
The net impact of cytomegalovirus (CMV) DNAemia on overall mortality (OM) and nonrelapse mortality (NRM) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. This was a retrospective, multicenter, noninterventional study finally including 749 patients. CMV DNA monitoring was conducted by real-time polymerase chain reaction (PCR) assays. Clinical outcomes of interest were OM and NRM through day 365 after allo-HSCT. The cumulative incidence of CMV DNAemia in this cohort was 52.6%. A total of 306 out of 382 patients with CMV DNAemia received preemptive antiviral therapy (PET). PET use for CMV DNAemia, but not the occurrence of CMV DNAemia, taken as a qualitative variable, was associated with increased OM and NRM in univariate but not in adjusted models. A subcohort analysis including patients monitored by the COBAS Ampliprep/COBAS Taqman CMV Test showed that OM and NRM were comparable in patients in whom either low or high plasma CMV DNA threshold (<500 vs ≥500 IU/mL) was used for PET initiation. In conclusion, CMV DNAemia was not associated with increased OM and NRM in allo-HSCT recipients. The potential impact of PET use on mortality was not proven but merits further research. 相似文献