全文获取类型
收费全文 | 85篇 |
免费 | 2篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 7篇 |
基础医学 | 7篇 |
口腔科学 | 1篇 |
临床医学 | 10篇 |
内科学 | 10篇 |
皮肤病学 | 5篇 |
神经病学 | 10篇 |
外科学 | 19篇 |
预防医学 | 5篇 |
药学 | 4篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 5篇 |
2014年 | 1篇 |
2013年 | 11篇 |
2012年 | 3篇 |
2011年 | 3篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 5篇 |
2007年 | 4篇 |
2006年 | 2篇 |
2005年 | 8篇 |
2004年 | 2篇 |
2003年 | 6篇 |
2002年 | 7篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1992年 | 1篇 |
排序方式: 共有87条查询结果,搜索用时 0 毫秒
1.
Kalogerou A Gelou E Mountantonakis S Settas L Zafiriou E Sakkas L 《Annals of the rheumatic diseases》2005,64(8):1233-1235
OBJECTIVES: To determine if T cells in skin lesions in systemic sclerosis (SSc) express the early activation antigen CD69 that participates in cell-cell interactions. METHODS: Skin biopsy specimens from 17 patients with SSc were analysed by immunohistochemistry using the indirect peroxidase method and monoclonal antibodies for CD3 (T cell marker), CD69 (early T cell activation marker), and CD68 (macrophage marker). RESULTS: Mononuclear cells, containing mostly T cells and macrophages, were increased in SSc skin lesions and were present in perivascular areas. CD69 was expressed in these mononuclear cells. There was no correlation between the number of CD3+, CD69+, or CD68+ cells and the Rodnan skin score or disease duration. CONCLUSIONS: The expression of early T cell activation antigen CD69 in skin lesions suggests that T cells may actively participate in cell-cell contact with fibroblasts to promote fibrosis. 相似文献
2.
3.
4.
Bostantjopoulou S Katsarou Z Georgiadis G Zafiriou D Kazis A 《Clinical neuropharmacology》2002,25(2):115-118
The purpose of this study was to evaluate the effect of amantadine sulfate infusion on the N30 component of the median nerve short-latency somatosensory evoked potentials (SSEPs) in patients with Parkinson's disease (PD). Twenty patients with advanced PD and severe motor fluctuations received a 6-day course of amantadine sulfate infusion (400 mg/day) plus their usual levodopa medication. Patients were assessed clinically by means of the Unified Parkinson's Disease Rating Scale (UPDRS-III and -IV). SSEPs to median nerve stimulation were recorded from the parietal and frontal regions before and after the 6-day course of amantadine infusion. Mean UPDRS motor score during the ON and OFF phase improved after amantadine infusion, as did motor fluctuations. SSEP changes resulting from amantadine sulfate treatment were observed in the P20-N30 amplitude as follows: Mean P20-N30 amplitudes before and after treatment were 2.15 +/- 1.11 microV and 3.06 +/- 1.19 microV respectively (p = 0.000), whereas mean N30-P40 amplitude increased from 2.7 +/- 1.6 microV to 3.9 +/- 1.3 microV after treatment (p = 0.000). Our results indicate that coincident to its clinical impact, amantadine infusion in patients with PD affects electrophysiologic parameters as well. 相似文献
5.
6.
Tryfou Elsi S. Kostakou Peggy M. Chasikidis Christos G. Kostopoulos Vassilios S. Serafetinidis Ioannis I. Ferdianaki Efterpi K. Mihas Constantinos Olympios Christoforos D. Kouris Nikos T. 《The international journal of cardiovascular imaging》2022,38(5):995-1003
The International Journal of Cardiovascular Imaging - Although severe acute respiratory syndrome coronavirus 2 causes respiratory disease, it may also lead to cardiovascular involvement with... 相似文献
7.
Evangelos J Giamarellos-Bourboulis Efterpi Apostolidou Malvina Lada Ioannis Perdios Nikolaos K Gatselis Iraklis Tsangaris Marianna Georgitsi Magdalini Bristianou Theodora Kanni Kalliopi Sereti Miltiades A Kyprianou Anastasia Kotanidou Apostolos Armaganidis 《Critical care (London, England)》2013,17(5):R247
Introduction
The aim of this study was to investigate the kinetics of immunoglobulin M (IgM) during the different stages of sepsis.Methods
In this prospective multicenter study, blood sampling for IgM measurement was done within the first 24 hours from diagnosis in 332 critically ill patients; in 83 patients this was repeated upon progression to more severe stages. Among these 83 patients, 30 patients with severe sepsis progressed into shock and IgM was monitored daily for seven consecutive days. Peripheral blood mononuclear cells (PBMCs) were isolated from 55 patients and stimulated for IgM production.Results
Serum IgM was decreased in septic shock compared to patients with systemic inflammatory response syndrome (SIRS) and patients with severe sepsis. Paired comparisons at distinct time points of the sepsis course showed that IgM was decreased only when patients deteriorated from severe sepsis to septic shock. Serial measurements in these patients, beginning from the early start of vasopressors, showed that the distribution of IgM over time was significantly greater for survivors than for non-survivors. Production of IgM by PBMCs was significantly lower at all stages of sepsis compared with healthy controls.Conclusions
Specific changes of circulating IgM occur when patients with severe sepsis progress into septic shock. The distribution of IgM is lower among non-survivors. 相似文献8.
Natalie Tourkantoni Miranda Athanassiou-Metaxa Dimitrios Zafiriou Vassiliki Tzimouli Marina Economou Antonia Taparkou 《Hemoglobin》2013,37(1-2):35-40
Deferiprone (L1), has previously been reported to be associated with immunological abnormalities in iron loaded thalassemia patients. However, other factors may also have similar effects such as the level of iron overload, chronic immuno-stimulation due to transfusions, splenectomy and deferoxamine (DFO). During chelation therapy with DFO, several complications have been reported, which were due to pharmacological activity and high dose toxicity with regard to both acoustic and visual effects, as well as peripheral nerve disorders that were measured by nerve conduction velocities. The immune and neural status of 44 β-thalassemic patients, aged 10–30 years (mean 19.4 ± 4.9), receiving L1 as a monotherapy (n = 21), or in combination with DFO (n = 23), has been followed for 2 years by monitoring the level of immunoglobulins (IgG, IgM, IgA), the level of T and B lymphocytes (CD4/CD8), the auto antibodies: anti nuclear (ANA), anti-double-stranded (anti-ds DNA), anti reticulin (anti-R1), anti-extra nuclear (anti-ENA), anti histone (anti-AHA), anti liver-kidney-muscle (anti-LKM), anti-smooth muscle (anti-SMA), anti-thyroid (anti-ATA), anti-mitochondrial (anti-AMA) antibodies and the C-reactive protein. The percentage of patients with disorders of the immune and nervous system concerned very few cases. None of our patients with pathological findings in their immunological or neurophysiological examinations presented any signs or symptoms of involvement of the immune or nervous system. Further advantages have been identified for the oral use of L1 and its combination with DFO, including synergistic efficacy and lower dosing with limited toxicity. 相似文献
9.
Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited condition with a prevalence of one in 40?000 individuals. It causes the development of tumours in endocrine glands, such as medullary thyroid cancer, pheochromocytomas, as well as primary hyperparathyroidism. MEN 2A in pregnancy is very rare with only 29 cases reported in the literature. The presence of pheochromocytoma is a rare cause of hypertension during pregnancy with an incidence of 0.007% of all pregnancies. This has severe implications on both mother and the foetus. This case report describes a 22-year-old nulliparous Caucasian woman with known MEN2A syndrome, who underwent thyroidectomy for medullary thyroid carcinoma in childhood and excision of left sided pheochromocytoma at the age of 19. She was found to have a recurrence of pheochromocytoma in the right adrenal gland during pregnancy at 16 weeks of gestation and was oddly normotensive. Catecholamine effects were blocked with phenoxybenzamine and she delivered by an uneventful elective caesarean section at 36 weeks gestation. She underwent a laparoscopic right adrenalectomy six weeks postpartum, followed by lifelong corticosteroid replacement. 相似文献
10.
Efterpi C Demiri Dimitrios D Dionyssiou Ioannis Biskiniotis Dimitrios Papadimitriou 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2007,41(1):42-44
We used a reverse dorsal digitometacarpal flap to reconstruct a degloved finger in a 60-year-old patient who had an avulsion digital amputation. The digitometacarpal island dorsal flap was raised on the vascular axis of the ring finger and wrapped around the degloved little finger. The long term results were good. 相似文献