排序方式: 共有21条查询结果,搜索用时 15 毫秒
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Effrossyni Gkrania-Klotsas MD MPH Fiona J. Cooke MD PhD Vasileios Zochios MD Nikoletta Lofitou MD 《Journal of travel medicine》2009,16(1):57-59
Fever, caused by Salmonella typhi , is the cause of significant morbidity worldwide. Extraintestinal manifestations of typhoid fever can confuse clinicians in Western countries, delaying diagnosis. We present an extraordinary case of typhoid fever, manifesting as hand cyanosis as well as abducens nerve paresis, all of which promptly resolved with antibiotics. 相似文献
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Thwaites GE Edgeworth JD Gkrania-Klotsas E Kirby A Tilley R Török ME Walker S Wertheim HF Wilson P Llewelyn MJ;UK Clinical Infection Research Group 《The Lancet infectious diseases》2011,11(3):208-222
Staphylococcus aureus bacteraemia is one of the most common serious bacterial infections worldwide. In the UK alone, around 12,500 cases each year are reported, with an associated mortality of about 30%, yet the evidence guiding optimum management is poor. To date, fewer than 1500 patients with S aureus bacteraemia have been recruited to 16 controlled trials of antimicrobial therapy. Consequently, clinical practice is driven by the results of observational studies and anecdote. Here, we propose and review ten unanswered clinical questions commonly posed by those managing S aureus bacteraemia. Our findings define the major areas of uncertainty in the management of S aureus bacteraemia and highlight just two key principles. First, all infective foci must be identified and removed as soon as possible. Second, long-term antimicrobial therapy is required for those with persistent bacteraemia or a deep, irremovable focus. Beyond this, the best drugs, dose, mode of delivery, and duration of therapy are uncertain, a situation compounded by emerging S aureus strains that are resistant to old and new antibiotics. We discuss the consequences on clinical practice, and how these findings define the agenda for future clinical research. 相似文献
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S. Odolini P. Parola E. Gkrania-Klotsas E. Caumes P. Schlagenhauf R. López-Vélez G.-D. Burchard F. Santos-O'Connor L. Weld F. von Sonnenburg V. Field P. de Vries M. Jensenius L. Loutan F. Castelli 《Clinical microbiology and infection》2012,18(5):468-474
The aim of this study was to investigate travel-associated morbidity in European travellers in 2009 in comparison with 2008, with a particular emphasis on emerging infectious diseases with the potential for introduction into Europe. Diagnoses with demographic, clinical and travel-related predictors of disease from ill returning travelers presenting to 12 core EuroTravNet sites from January to December 2009 were analysed. A total of 6392 patients were seen at EuroTravNet core sites in 2009, as compared with 6957 in 2008. As compared with 2008, there was a marked increase in the number of travellers exposed in North America and western Europe. Respiratory illnesses, in particular pandemic A(HINI) influenza, influenza-like syndromes, and tuberculosis, were also observed more frequently. A significant increase in reported dengue cases in 2009 as compared with 2008 was observed (n = 172, 2.7% vs. n = 131, 1.90%) (p 0.002). The numbers of malaria and chikungunya cases were also increasing, although not significantly. Two deaths were recorded: visceral leishmaniasis and sepsis in a Sudanese migrant, and Acinetobacter sp. pneumonia in a patient who had visited Spain. This is the most comprehensive hensy of travel-related illness in Europe in 2009 as compared with 2008. A significant increase in travel-related respiratory and vector-borne infections was observed, highlighting the potential risk for introduction of these diseases into Europe, where competent vectors are present. The number of traveller deaths is probably underestimated. The possible role of the travellers in the emergence of infectious diseases of public health concern is highlighted. 相似文献
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Mark Depner Sebastian Fuchs Jan Raabe Natalie Frede Cristina Glocker Rainer Doffinger Effrossyni Gkrania-Klotsas Dinakantha Kumararatne T. Prescott Atkinson Harry W. SchroederJr. Tim Niehues Gregor Dückers Asbjørg Stray-Pedersen Ulrich Baumann Reinhold Schmidt Jose L. Franco Julio Orrego Moshe Ben-Shoshan Christine McCusker Cristina Miuki Abe Jacob Magda Carneiro-Sampaio Lisa A. Devlin J. David M. Edgar Paul Henderson Richard K. Russell Anne-Bine Skytte Suranjith L. Seneviratne Jennifer Wanders Hans Stauss Isabelle Meyts Leen Moens Milos Jesenak Robin Kobbe Stephan Borte Michael Borte Dowain A. Wright David Hagin Troy R. Torgerson Bodo Grimbacher 《Journal of clinical immunology》2016,36(1):73-84
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Rona M Connick Peter Connick Angelos E Klotsas Petroula A Tsagkaraki Effrossyni Gkrania-Klotsas 《BMC medical education》2009,9(1):2-8