全文获取类型
收费全文 | 1047篇 |
免费 | 70篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 39篇 |
妇产科学 | 6篇 |
基础医学 | 130篇 |
口腔科学 | 17篇 |
临床医学 | 138篇 |
内科学 | 177篇 |
皮肤病学 | 17篇 |
神经病学 | 43篇 |
特种医学 | 104篇 |
外科学 | 106篇 |
综合类 | 28篇 |
预防医学 | 79篇 |
眼科学 | 24篇 |
药学 | 108篇 |
中国医学 | 2篇 |
肿瘤学 | 154篇 |
出版年
2021年 | 15篇 |
2020年 | 9篇 |
2019年 | 9篇 |
2018年 | 10篇 |
2017年 | 18篇 |
2016年 | 13篇 |
2015年 | 22篇 |
2014年 | 16篇 |
2013年 | 26篇 |
2012年 | 47篇 |
2011年 | 29篇 |
2010年 | 34篇 |
2009年 | 32篇 |
2008年 | 33篇 |
2007年 | 75篇 |
2006年 | 39篇 |
2005年 | 39篇 |
2004年 | 29篇 |
2003年 | 24篇 |
2002年 | 29篇 |
2001年 | 40篇 |
2000年 | 35篇 |
1999年 | 38篇 |
1998年 | 36篇 |
1997年 | 45篇 |
1996年 | 33篇 |
1995年 | 25篇 |
1994年 | 19篇 |
1993年 | 29篇 |
1991年 | 22篇 |
1990年 | 21篇 |
1989年 | 31篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 14篇 |
1985年 | 11篇 |
1984年 | 18篇 |
1983年 | 11篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 16篇 |
1979年 | 8篇 |
1977年 | 8篇 |
1976年 | 13篇 |
1975年 | 13篇 |
1974年 | 9篇 |
1973年 | 9篇 |
1972年 | 11篇 |
1970年 | 7篇 |
1969年 | 8篇 |
排序方式: 共有1178条查询结果,搜索用时 15 毫秒
1.
The initial management of bladder outflow obstruction typically related to benign prostatic hyperplasia (BPH) falls to a large extent within the remit of general practice. Referral onwards to secondary care typically arises following the failure to respond to conservative measures or when complications have supervened; the most significant of which is urinary retention. In the hospital setting, anaesthesia, constipation and immobility are the common precipitants. What follows is a practical guide to the management of these situations and provides an overview of the conservative, medical, minimally invasive and surgical treatments available. 相似文献
2.
The diagnosis of albinism is indicated by the presence of visual pathway misrouting in which temporal retinal fibers erroneously decussate at the optic chiasm disrupting the normal topographical distribution of retinal geniculate-cortical projections. Detection of misrouted fibers is effected by non-invasive electrophysiological assessment of the topographical representation of the visual evoked potential (VEP) following full field monocular stimulation. By combining appropriate state defined neonatal recording procedures with the albino VEP test paradigm, the presence of aberrant optic pathway projections was detected in a five-day-old full-term infant. The electrophysiological signature pathognomonic to albinism was observed within a long (300 ms) latency window of an otherwise normal neonatal luminance flash response. The results of this study indicate that the VEP misrouting test can be extended to reliable albino diagnosis within the neonatal period. 相似文献
3.
4.
5.
Christiane Eckhardt Jesse S Halvosa Susan M Ray Henry M Blumberg 《Infection control and hospital epidemiology》2003,24(6):460-461
Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been a nosocomial pathogen. However, several recent studies have noted community-acquired MRSA among young, healthy patients with no risk factors or healthcare system exposure. We report the transmission of a strain of community-acquired MRSA in our neonatal intensive care unit. 相似文献
6.
Lee L. Eckhardt MD Amanda L. Farley MS Esther Rodriguez MD Karen Ruwaldt BS Daniel Hammill David J. Tester BS Michael J. Ackerman MD PhD Jonathan C. Makielski MD 《Heart rhythm》2007,4(3):323-329
BACKGROUND: Loss-of-function mutations in the KCNJ2 cause approximately 50% of Andersen-Tawil Syndrome (ATS) characterized by a classic triad of periodic paralysis, ventricular arrhythmia, and dysmorphic features. Do KCNJ2 mutations occur in patients lacking this triad and lacking a family history of ATS? OBJECTIVES: The purpose of this study was to identify and characterize mutations in the KCNJ2-encoded inward rectifier potassium channel Kir2.1 from patients referred for genetic arrhythmia testing. METHODS: Mutational analysis of KCNJ2 was performed for 541 unrelated patients. The mutations were made in wild type (WT) and expressed in COS-1 cells and voltage clamped for ion currents. RESULTS: Three novel missense mutations (R67Q, R85W, and T305A) and one known mutation (T75M) were identified in 4/249 (1.6%) patients genotype-negative for other known arrhythmia genes with overall incidence 4/541 (0.74%). They had prominent U-waves, marked ventricular ectopy, and polymorphic ventricular tachycardia but no facial/skeletal abnormalities. Periodic paralysis was present in only one case. Outward current was decreased to less than 5% of WT for all mutants expressed alone. Co-expression with WT (simulating heterozygosity) caused a marked dominant negative effect for T75M and R82W, no dominant negative effect for R67Q, and a novel selective enhancement of inward rectification for T305A. CONCLUSIONS: KCNJ2 loss of function mutations were found in approximately 1% of patients referred for genetic arrhythmia testing that lacked criteria for ATS. Characterization of three new mutations identified a novel dominant negative effect selectively reducing outward current for T305A. These results extend the range of clinical phenotype and molecular phenotype associated with KCNJ2 mutations. 相似文献
7.
Background
There is currently an unprecedented expressed need and demand for estimates of maternal mortality in developing countries. This has been stimulated in part by the creation of a Millennium Development Goal that will be judged partly on the basis of reductions in maternal mortality by 2015. 相似文献8.
9.
Silvia Obenauer Christian Sohns Carola Werner Eckhardt Grabbe 《Journal of digital imaging》2006,19(3):258-263
The goal of this study was to evaluate the performance of a computer-aided detection (CAD) system in full-field digital mammography
(Senographe 2000D, General Electric, Buc, France) in finding out carcinomas depending on the parenchymal density. A total
of 226 mediolateral oblique (MLO) and 186 craniocaudal (CC) mammographic views of histologically proven cancers were retrospectively
evaluated with a digital CAD system (ImageChecker V2.3 R2 Technology, Los Altos, CA, USA). Malignant tumors were detected
correctly by CAD in MLO view in 84.85% in breasts with parenchymal tissue density of the American College of Radiology (ACR)
type 1, in 70.33% of the ACR type 2, in 68.12% of the ACR type 3, and in 69.70% of the ACR type 4. For the CC view, similar
results were found according to the ACR types. Using the chi-square and McNemar tests, there was no statistical significance.
However, a trend of better detection could be seen with decreasing ACR type. In conclusion, there seems to be a tendency for
breast tissue density to affect the detection rate of breast cancer when using the CAD system. 相似文献
10.