全文获取类型
收费全文 | 16290篇 |
免费 | 1074篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 126篇 |
儿科学 | 490篇 |
妇产科学 | 493篇 |
基础医学 | 2732篇 |
口腔科学 | 278篇 |
临床医学 | 2044篇 |
内科学 | 2743篇 |
皮肤病学 | 429篇 |
神经病学 | 1457篇 |
特种医学 | 319篇 |
外科学 | 1400篇 |
综合类 | 97篇 |
一般理论 | 38篇 |
预防医学 | 1830篇 |
眼科学 | 262篇 |
药学 | 1333篇 |
中国医学 | 30篇 |
肿瘤学 | 1295篇 |
出版年
2023年 | 134篇 |
2022年 | 277篇 |
2021年 | 588篇 |
2020年 | 296篇 |
2019年 | 520篇 |
2018年 | 547篇 |
2017年 | 377篇 |
2016年 | 485篇 |
2015年 | 468篇 |
2014年 | 649篇 |
2013年 | 820篇 |
2012年 | 1194篇 |
2011年 | 1262篇 |
2010年 | 675篇 |
2009年 | 561篇 |
2008年 | 944篇 |
2007年 | 992篇 |
2006年 | 964篇 |
2005年 | 890篇 |
2004年 | 768篇 |
2003年 | 691篇 |
2002年 | 663篇 |
2001年 | 142篇 |
2000年 | 125篇 |
1999年 | 125篇 |
1998年 | 126篇 |
1997年 | 85篇 |
1996年 | 82篇 |
1995年 | 73篇 |
1994年 | 78篇 |
1993年 | 54篇 |
1992年 | 88篇 |
1991年 | 119篇 |
1990年 | 107篇 |
1989年 | 93篇 |
1988年 | 93篇 |
1987年 | 86篇 |
1986年 | 94篇 |
1985年 | 104篇 |
1984年 | 77篇 |
1983年 | 62篇 |
1982年 | 52篇 |
1981年 | 55篇 |
1980年 | 49篇 |
1979年 | 53篇 |
1978年 | 52篇 |
1976年 | 51篇 |
1975年 | 51篇 |
1974年 | 54篇 |
1973年 | 62篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Andres Eduardo Campuzano-García Bertha Torres-Alvarez Diana Hernández-Blanco 《Journal of cosmetic and laser therapy》2015,17(4):213-215
Hailey–Hailey disease (HHD), also known as benign familial pemphigus, is an autosomal dominant skin condition that affects the adhesion of epidermal keratinocytes. Although the initial manifestation of flaccid vesicles on erythematous or normal skin in flexure sites frequently goes unnoticed, large, macerated, exudative plaques of superficial erosions with crusting are observed at the time of diagnosis. There is no specific treatment for HHD, and most cases are symptomatically supported. However, infrared laser ablation has been somewhat helpful. We present a case successfully treated with fractional CO2 laser showing a long-term favourable outcome and no adverse effects. Thus, this modality could be an alternative to full ablation for this condition. 相似文献
2.
3.
4.
Erika Cecon Anna Ivanova Marine Luka Florence Gbahou Anne Friederich Jean‐Luc Guillaume Patrick Keller Klaus Knoch Raise Ahmad Philippe Delagrange Michele Solimena Ralf Jockers 《Journal of pineal research》2019,66(2)
Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non‐24‐hour sleep‐wake disorders, and major depressive disorders. In mammals, two melatonin receptors (MTRs) exist, MT1 and MT2, belonging to the G protein‐coupled receptor (GPCR) superfamily. Similar to most other GPCRs, reliable antibodies recognizing melatonin receptors proved to be difficult to obtain. Here, we describe the development of the first monoclonal antibodies (mABs) for mouse MT1 and MT2. Purified antibodies were extensively characterized for specific reactivity with mouse, rat, and human MT1 and MT2 by Western blot, immunoprecipitation, immunofluorescence, and proximity ligation assay. Several mABs were specific for either mouse MT1 or MT2. None of the mABs cross‐reacted with rat MTRs, and some were able to react with human MTRs. The specificity of the selected mABs was validated by immunofluorescence microscopy in three established locations (retina, suprachiasmatic nuclei, pituitary gland) for MTR expression in mice using MTR‐KO mice as control. MT2 expression was not detected in mouse insulinoma MIN6 cells or pancreatic beta‐cells. Collectively, we report the first monoclonal antibodies recognizing recombinant and native mouse melatonin receptors that will be valuable tools for future studies. 相似文献
5.
6.
Ana M. Gómez Angelica Imitola Diana Henao Maira García-Jaramillo Marga Giménez Clara Viñals Bruno Grassi Mariana Torres Isabella Zuluaga Oscar Mauricio Muñoz Martin Rondón Fabián León-Vargas Ignacio Conget 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):267-272
Background and aimsDespite using sensor-augmented pump therapy (SAPT) with predictive low-glucose management (PLGM), hypoglycemia is still an issue in patients with type 1 Diabetes (T1D). Our aim was to determine factors associated with clinically significant hypoglycemia (<54 mg/dl) in persons with T1D treated with PLGM-SAPT.Methodology: This is a multicentric prospective real-life study performed in Colombia, Chile and Spain. Patients with T1D treated with PLGM-SAPT, using sensor ≥70% of time, were included. Data regarding pump and sensor use patterns and carbohydrate intake from 28 consecutive days were collected. A bivariate and multivariate Poisson regression analysis was carried out, to evaluate the association between the number of events of <54 mg/dl with the clinical variables and patterns of sensor and pump use.Results188 subjects were included (41 ± 13.8 years-old, 23 ± 12 years disease duration, A1c 7.2% ± 0.9). The median of events <54 mg/dl was four events/patient/month (IQR 1–10), 77% of these events occurred during day time. Multivariate analysis showed that the number of events of hypoglycemia were higher in patients with previous severe hypoglycemia (IRR1.38; 95% CI 1.19–1.61; p < 0.001), high glycemic variability defined as Coefficient of Variation (CV%) > 36% (IRR 2.09; 95%CI 1.79–2.45; p < 0.001) and hypoglycemia unawareness. A protector effect was identified for adequate sensor calibration (IRR 0.77; 95%CI 0.66–0.90; p:0.001), and the use of bolus wizard >60% (IRR 0.74; 95%CI 0.58–0.95; p:0.017).ConclusionIn spite of using advanced SAPT, clinically significant hypoglycemia is still a non-negligible risk. Only the identification and intervention of modifiable factors could help to prevent and reduce hypoglycemia in clinical practice. 相似文献
7.
8.
Peffault de Latour Rgis Huynh Lynn Ivanova Jasmina I. Totev Todor Bilginsoy Mehmet Antin Joseph Roy Anuja Duh Mei Sheng 《Annals of hematology》2020,99(4):743-752
Annals of Hematology - This study assessed treatment patterns and healthcare resource utilization (HRU) of patients with severe aplastic anemia (SAA) with insufficient response to immunosuppressive... 相似文献
9.
María Cabrerizo Gloria Trallero María José Pena Amaia Cilla Gregoria Megias Carmen Mu?oz-Almagro Eva Del Amo Diana Roda Ana Isabel Mensalvas Antonio Moreno-Docón Juan García-Costa Nuria Rabella Manuel Ome?aca María Pilar Romero Sara Sanbonmatsu-Gámez Mercedes Pérez-Ruiz María José Santos-Mu?oz Cristina Calvo And the study group of “Enterovirus parechovirus infections in children under ?years-old Spain” PI- 《European journal of pediatrics》2015,174(11):1511-1516
10.
Toneva Diana H. Nikolova Silviya Y. Tasheva-Terzieva Elena D. Zlatareva Dora K. Lazarov Nikolai E. 《International journal of legal medicine》2022,136(6):1851-1863
International Journal of Legal Medicine - Sex identification is a primary step in forensic analysis of skeletal remains. The accuracy of sex estimation methods greatly depends on the sexual... 相似文献