全文获取类型
收费全文 | 499篇 |
免费 | 11篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 20篇 |
妇产科学 | 14篇 |
基础医学 | 62篇 |
口腔科学 | 2篇 |
临床医学 | 32篇 |
内科学 | 150篇 |
皮肤病学 | 3篇 |
神经病学 | 2篇 |
特种医学 | 5篇 |
外科学 | 118篇 |
综合类 | 5篇 |
一般理论 | 1篇 |
预防医学 | 30篇 |
眼科学 | 14篇 |
药学 | 31篇 |
肿瘤学 | 20篇 |
出版年
2023年 | 8篇 |
2022年 | 6篇 |
2021年 | 24篇 |
2020年 | 10篇 |
2019年 | 11篇 |
2018年 | 14篇 |
2017年 | 11篇 |
2016年 | 13篇 |
2015年 | 11篇 |
2014年 | 18篇 |
2013年 | 27篇 |
2012年 | 39篇 |
2011年 | 40篇 |
2010年 | 16篇 |
2009年 | 18篇 |
2008年 | 20篇 |
2007年 | 25篇 |
2006年 | 32篇 |
2005年 | 19篇 |
2004年 | 26篇 |
2003年 | 31篇 |
2002年 | 27篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 3篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 4篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 6篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有516条查询结果,搜索用时 46 毫秒
1.
慢性胰腺炎的临床表现包括疼痛、脂肪泻和糖尿病。在西方国家,慢性胰腺炎最常见的病因是酗酒。70%以上的病人在就诊时有疼痛的临床表现,而且,这些患者中又有75%以上会在几年之后出现疼痛减轻或完全消失。对于所有的慢性胰腺炎的病人来说,均应排除非胰源性疼痛和胆道梗阻、胰腺假性囊肿等胰腺局部并发症。应建议所有慢性胰腺炎病人戒烟、戒酒。阿片类镇痛剂仅应用于治疗疼痛严重的病人。尽管有报道认为胰酶替代治疗有助于止痛,但是,对于已经确诊的慢性胰腺炎病人来说,该疗法无效。激素类药物进行腹腔神经丛阻滞术可能有助于病人度过剧烈疼痛期。顽固性疼痛是进行胰液引流或胰腺切除的适应证。建议应用适量胰酶替代联合(或不联合)制酸剂治疗营养不良。慢性胰腺炎导致的糖尿病与原发性糖尿病的治疗原则相似。 相似文献
2.
James W. Verbsky Mary K. Hintermeyer Pippa M. Simpson Mingen Feng Jody Barbeau Nagarjun Rao Carlyne D. Cool Luis A. Sosa-Lozano Dhiraj Baruah Erin Hammelev Alyssa Busalacchi Amy Rymaszewski Jeff Woodliff Shaoying Chen Mary Bausch-Jurken John M. Routes 《The Journal of allergy and clinical immunology》2021,147(2):704-712.e17
3.
The first step of enzyme linked immunosorbent assay (ELISA), namely, adsorption of antigen or antibody to the plastic microtiter well plate, was studied as a function of insolubility of IgG in water. Immobilization efficiency was assessed in terms of number of wells coated per milliliter of primary antiserum. We have compared different coating/immobilization protocols, i.e., direct and indirect immobilization of primary antibody to the plastic microtiter well plate using carbonate buffer and phosphate buffer with glutaraldehyde. We have observed efficient coating when the immobilization of primary antibody through an immunobridge technique was performed, where water was used as a coating medium. It gave a higher number of wells coated per milliliter of anti-serum (primary or secondary) than other compared coating protocols and it allowed the use of serum (non-immune) and anti-serum (primary and secondary antibody) dilutions, avoiding the need for gamma-globulin purification from normal and immunized serum. 相似文献
4.
Anuraag Shrivastav Shailly Varma Anurag Saxena John DeCoteau Rajendra K Sharma 《Journal of translational medicine》2007,5(1):58-6
Background
Colon cancer is the second leading cause of cancer deaths in the western world. If detected early, colorectal cancer is one of the most treatable forms of cancer. Unfortunately, very few people are screened. N-myristoyltransferase (NMT) catalyzes myristoylation of various proteins including oncoproteins. We have demonstrated earlier the alteration of NMT activity during the progression of colorectal cancer and established NMT as a putative therapeutic target for cancer. 相似文献5.
6.
7.
Shrinand V Vaidya Ambarish A Mathesul Atul N Panghate Roshan Wade Dhiraj V Sonawane 《Indian Journal of Orthopaedics》2012,46(2):239-241
We report a rare case of bilateral multiligament knee injury in an 18-year-old female employed in garment industry. Patient was wearing salwar kameez and dupatta while operating an electric laundry machine. In this case we discuss a peculiar mechanism of injury caused due to wearing dupatta near working site and suggest simple preventive measures. 相似文献
8.
Pangal Dhiraj J. Wishart Danielle Shiroishi Mark S. Ruzevick Jacob Carmichael John D. Zada Gabriel 《Pituitary》2022,25(3):480-485
Pituitary - Patterns of extension of pituitary adenomas (PA) may vary according to PA subtype. Understanding extrasellar extension patterns in growth hormone PAs (GHPA) vis-a-vis nonfunctional PAs... 相似文献
9.
Elharith M. Ahmed Frederick J. Barrera Edward A. Early Michael L. Denton C.D. Clark Dhiraj K. Sardar 《Computers in biology and medicine》2013,43(12):2278-2286
Since its invention in the early 1960s, the laser has been used as a tool for surgical, therapeutic, and diagnostic purposes. To achieve maximum effectiveness with the greatest margin of safety it is important to understand the mechanisms of light propagation through tissue and how that light affects living cells. Lasers with novel output characteristics for medical and military applications are too often implemented prior to proper evaluation with respect to tissue optical properties and human safety. Therefore, advances in computational models that describe light propagation and the cellular responses to laser exposure, without the use of animal models, are of considerable interest. Here, a physics-based laser–tissue interaction model was developed to predict the dynamic changes in the spatial and temporal temperature rise during laser exposure to biological tissues. Unlike conventional models, the new approach is grounded on the rigorous electromagnetic theory that accounts for wave interference, polarization, and nonlinearity in propagation using a Maxwell's equations-based technique. 相似文献
10.
Abhijit Chandra Vishal Gupta Manoj Kumar Anit Parihar Ashok Kumar Ramendra Jauhari Devendra Singh P. K. Shrivastav Pankaj Kumar 《Surgical and radiologic anatomy : SRA》2013,35(1):67-74