全文获取类型
收费全文 | 4321篇 |
免费 | 335篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 66篇 |
妇产科学 | 54篇 |
基础医学 | 527篇 |
口腔科学 | 53篇 |
临床医学 | 487篇 |
内科学 | 928篇 |
皮肤病学 | 40篇 |
神经病学 | 309篇 |
特种医学 | 169篇 |
外科学 | 734篇 |
综合类 | 96篇 |
一般理论 | 4篇 |
预防医学 | 343篇 |
眼科学 | 121篇 |
药学 | 329篇 |
中国医学 | 1篇 |
肿瘤学 | 387篇 |
出版年
2024年 | 4篇 |
2023年 | 50篇 |
2022年 | 77篇 |
2021年 | 173篇 |
2020年 | 66篇 |
2019年 | 141篇 |
2018年 | 159篇 |
2017年 | 102篇 |
2016年 | 107篇 |
2015年 | 121篇 |
2014年 | 213篇 |
2013年 | 237篇 |
2012年 | 370篇 |
2011年 | 390篇 |
2010年 | 228篇 |
2009年 | 172篇 |
2008年 | 277篇 |
2007年 | 303篇 |
2006年 | 246篇 |
2005年 | 253篇 |
2004年 | 224篇 |
2003年 | 225篇 |
2002年 | 196篇 |
2001年 | 37篇 |
2000年 | 30篇 |
1999年 | 18篇 |
1998年 | 32篇 |
1997年 | 18篇 |
1996年 | 17篇 |
1995年 | 8篇 |
1994年 | 6篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1987年 | 14篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 18篇 |
1983年 | 10篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1936年 | 4篇 |
1934年 | 3篇 |
排序方式: 共有4667条查询结果,搜索用时 46 毫秒
1.
2.
3.
4.
5.
Sourajit M.Mustafi Jaroslaw Harezlak Chandana Kodiweera Jennifer S.Randolph James C.Ford Heather A.Wishart Yu-Chien Wu 《中国神经再生研究》2019,(1)
Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasively characterized by advanced diffusion magnetic resonance imaging. Seven diffusion metrics were extracted from hybrid diffusion imaging acquisitions via classic diffusion tensor imaging, neurite orientation dispersion and density imaging, and q-space imaging. We investigated the sensitivity of the diffusion metrics in 36 sets of regions of interest in the brain white matter of six female patients(age 52.8 ± 4.3 years) with multiple sclerosis. Each region of interest set included a conventional T2-defined lesion, a matched perilesion area, and normal-appearing white matter. Six patients with multiple sclerosis(n = 5) or clinically isolated syndrome(n = 1) at a mild to moderate disability level were recruited. The patients exhibited microstructural alterations from normal-appearing white matter transitioning to perilesion areas and lesions, consistent with decreased tissue restriction, decreased axonal density, and increased classic diffusion tensor imaging diffusivity. The findings suggest that diffusion compartment modeling and q-spa ce analysis appeared to be sensitive for detecting subtle microstructural alterations between perilesion areas and normal-appearing white matter. 相似文献
6.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
7.
The relation of forearm mineral density to peripheral fractures in postmenopausal women 总被引:2,自引:0,他引:2
B E Nordin B E Chatterton C J Walker J Wishart 《The Medical journal of Australia》1987,146(6):300-304
Forearm bone mineral density was measured in 557 postmenopausal women from whom a history of fractures was also obtained. Known cases of osteoporosis were excluded. The mean age of the subjects was 59 years. Ninety-eight of the subjects had sustained a fracture since the menopause and 37 had done so before the menopause. There had been 188 fractures in all. The mean bone density was significantly lower in the subjects who had experienced a fracture than in those who had not experienced a fracture; this was also true of subjects who had suffered a fracture before the menopause. The lowest bone densities were observed in subjects who had suffered forearm fractures, followed by those who had suffered fractures of the rib, ankle and foot. The mean bone density in subjects with more than one fracture was significantly lower than in those with only one fracture. The difference in bone density between subjects with and without a history of fractures was most significant in the younger subjects and became progressively less significant with age. The estimated relative fracture risk was 3.1 in the group with the lowest bone densities and zero in the group with the highest bone densities. 相似文献
8.
9.
Acellular Pertussis Vaccine Protects against Exacerbation of Allergic Asthma Due to Bordetella pertussis in a Murine Model
下载免费PDF全文
![点击此处可从《Clinical and Vaccine Immunology : CVI》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Darren P. Ennis Joseph P. Cassidy Bernard P. Mahon 《Clinical and Vaccine Immunology : CVI》2005,12(3):409-417
The prevalence of asthma and allergic disease has increased in many countries, and there has been speculation that immunization promotes allergic sensitization. Bordetella pertussis infection exacerbates allergic asthmatic responses. We investigated whether acellular pertussis vaccine (Pa) enhanced or prevented B. pertussis-induced exacerbation of allergic asthma. Groups of mice were immunized with Pa, infected with B. pertussis, and/or sensitized to ovalbumin. Immunological, pathological, and physiological changes were measured to assess the impact of immunization on immune deviation and airway function. We demonstrate that immunization did not enhance ovalbumin-specific serum immunoglobulin E production. Histopathological examination revealed that immunization reduced the severity of airway pathology associated with sensitization in the context of infection and decreased bronchial hyperreactivity upon methacholine exposure of infected and sensitized mice. These data demonstrate unequivocally the benefit of Pa immunization to health and justify selection of Pa in mass vaccination protocols. In the absence of infection, the Pa used in this study enhanced the interleukin-10 (IL-10) and IL-13 responses and influenced airway hyperresponsiveness to sensitizing antigen; however, these data do not suggest that Pa contributes to childhood asthma overall. On the contrary, wild-type virulent B. pertussis is still circulating in most countries, and our data suggest that the major influence of Pa is to protect against the powerful exacerbation of asthma-like pathology induced by B. pertussis. 相似文献
10.
K Wishart 《The Practitioner》1998,242(1593):844-850