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排序方式: 共有472条查询结果,搜索用时 15 毫秒
1.
应用肝脏原位灌注模型,探讨了内皮素1(ET1)在内毒素所致肝损伤中的作用。选用Wistar大鼠24只,分为对照组、ET1组、内毒素组、内毒素+ET1抗体组。观察了肝组织中ET1、一氧化氮(NO)、前列环素(PGI2)、乳酸脱氢酶(LDH)、丙二醛(MDA)、三磷酸腺苷(ATP)和肝组织学变化。结果显示:内毒素能使肝组织ET1含量增加;内毒素和ET1均能使细胞脂质过氧化物形成和酶的漏出,还能使肝细胞浊肿变性;ET1抗体能部分拮抗内毒素所致的肝损伤。结果表明:ET1参与了内毒素所致的肝损伤作用。 相似文献
2.
Amiodarone is an iodinated antiarrhythmic agent that is effective in the treatment of atrial and ventricular arrhythmias. A number of side effects are seen, including pulmonary toxicity and thyroid dysfunction. A patient with both amiodarone-induced pneumonitis and hyperthyroidism who exhibited abnormal gallium activity in the lungs, as well as diffuse gallium uptake in the thyroid gland is presented. The latter has not been previously reported and supports the concept of iodide-induced "thyroiditis" with gallium uptake reflecting the inflammatory response. 相似文献
3.
Use of polyethylene glycol (PEG) to promote adsorption of autoantibodies is reported to give good recovery of concomitant alloantibodies. In initial experiments, PEG and ZZAP (Ficin and DTT) adsorption procedures were compared for removal of autoantibody and recovery of alloantibody. Postadsorption studies (n = 11) were performed and hemagglutination scores compared. In subsequent studies, equal volumes of alloantibody containing sera, PEG, and antigen-negative red blood cells (RBCs) were used in twofold adsorption experiments. Saline was substituted for PEG for control purposes. Postadsorption titers and immunoglobulin levels were determined. Autoantibodies were completely removed by both methods (n = 5); better by PEG (n = 3); better by ZZAP (n = 1); and not adsorbed (n = 1), and partially adsorbed by both (n = 1). Alloantibody recovery was comparable in three cases (E, K, Jka) but weaker by at least one reaction grade in four (K,E, Jka, and antibody to low-frequency antigen). The latter anti-Jka reacted 1+ with Jk(a+b+) RBCs after ZZAP adsorption but was nonreactive with the same RBCs following PEG adsorption. Titers of six alloantibodies adsorbed with antigen-negative RBCs in PEG were markedly weaker (range 2 to 8) compared to saline controls (range 4 to 32). IgG levels for PEG adsorbed (range 128 to 243 mg/dL) were 50% lower than controls (range 265 to 505 mg/dL). Although PEG adsorption is effective in removing autoantibody, the precipitation of immunoglobulin by PEG may result in failure to detect underlying alloantibody. 相似文献
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5.
Drug adherence is one of the important aspects in caring for patients with allergic rhinitis. To improve clinical efficacy of early treatment for Japanese cedar pollinosis (JCP), we evaluated the effect of drug adherence on patients' outcomes. Patients were randomly selected from 16 ENT clinical sites in Osaka and Wakayama between February 24 and March 8, 2003 (peak pollen season). Efficacy was assessed using patients' ratings of nasal and ocular symptoms and overall assessment in their condition compared with previous season ones. Costs include direct costs of the drugs used for treatment to JCP from January to February. Five hundred one patients taking early treatment were enrolled. Compared to low adherence patients, those who reported higher level of adherence significantly improved overall health condition, and achieved better symptom relief of rhinorrhea and nasal congestion. In multiple logistic regression analysis, the following factors were independent risk factors for low adherence: student (p=0.002), using OTC medications (p=0.006), and short-duration of medication (p=0.001). Low costs were also risk factor for low adherence. We conclude that taking medications for JCP for 22-28 days is the best way to enhance patients' outcomes. 相似文献
6.
Dong Dake Xu Xiaowei Feng Cheng Xiong Huizi Pan Zhanyan 《Lasers in medical science》2021,36(1):139-146
Lasers in Medical Science - Phototherapy is an effective therapeutic option in the treatment of vitiligo; however, responses varied among the different types. The underlying mechanism has scarcely... 相似文献
7.
目的运用FRAX探究中国RA患者骨折风险及相关临床危险因素。方法纳入52例RA、47例p SS以及41例体检健康者分别为RA组、p SS组、对照组,RA组患者检测ACPA、RF、ESR、CRP并计算DAS28-ESR、HAQ-DI,所有纳入者以双能X线吸收测定法测定骨密度并通过FRAX官方网站预估10年骨折风险。所有统计分析采用SPSS统计软件。结果 FRAX相关骨折危险因素包括身高、吸烟、饮酒、既往骨折、父母骨折,在3组间差异未见统计学意义。RA组糖皮质激素累积服用天数高于p SS组(P0.05)。通过FRAX无论是否结合骨密度评估,RA组主要骨质疏松性骨折风险及髋关节骨折风险均较对照组高(P0.01),主要骨质疏松性骨折风险亦较p SS组高(P0.05或P0.01)。通过FRAX结合骨密度评估,从年龄、糖皮质激素、绝经方面分析,RA组主要骨质疏松性骨折及髋关节骨折风险均较对照组高(P0.05或P0.01)。通过FRAX结合BMD评估RA组10年主要骨质疏松性骨折风险发生率分为低危、中危、高危组,ACPA、RF、ESR、CRP、DAS28-ESR、HAQ-DI在三组中均值呈上升趋势,差异均有统计学意义(P0.01)。结论 RA患者骨折风险评估可结合FRAX与骨密度;长期、大量服用糖皮质激素以及高龄、绝经后女性RA患者更应重视骨折风险评估;有效控制RA疾病活动度、改善关节功能情况有助于骨质疏松性骨折的预防。 相似文献
8.
Diagnostic yield of MR-guided liver biopsies compared with CT- and US-guided liver biopsies 总被引:4,自引:0,他引:4
Schmidt AJ Kee ST Sze DY Daniel BL Razavi MK Semba CP Dake MD 《Journal of vascular and interventional radiology : JVIR》1999,10(10):1323-1329
PURPOSE: To compare diagnostic yield and complication rates of magnetic resonance (MR)-guided versus computed tomography (CT)- and ultrasound (US)-guided liver biopsies. MATERIALS AND METHODS: MR-, CT-, and US-guided liver biopsies performed between 9/96 and 9/98 were compared. Sixty patients (21 men and 39 women, mean age 60 years) underwent MR-guided biopsy of liver lesions. Thirty patients (16 men and 14 women, mean age 59 years) underwent CT-guided biopsy. Eighteen patients (seven men and 11 women, mean age 50 years) underwent US-guided biopsy. MR procedures were performed in an open-configuration 0.5-T Signa SP MR unit. Lesion localization used standard T1 and T2 sequences, whereas biopsies were performed with multiplanar spoiled gradient recalled echo and fast gradient recalled echo sequences. A coaxial system with an MR-compatible 18-gauge stabilizing needle and a 21-gauge aspiration needle was used to obtain all samples. In CT and US procedures, a 19-gauge stabilizing needle and a 21-gauge aspiration or a 20-gauge core biopsy needle were used. A cytotechnologist was present to determine the adequacy of samples. RESULTS: MR had a diagnostic yield of 61%. CT and US had diagnostic yields of 67% and 61%, respectively. No serious complications were reported for MR and US procedures. Two CT biopsies resulted in postprocedural hemorrhage. One patient required surgical exploration and died. CONCLUSIONS: MR-guided biopsy of liver lesions with use of a 0.5-T open-configuration magnet is safe and accurate when compared with CT and US. No statistical difference was observed between the diagnostic yield of biopsies performed with MR, CT, and US guidance. MR enabled biopsy of a number of lesions in the hepatic dome and lesions with low contrast, which would normally be difficult to sample safely with use of CT or US. 相似文献
9.
斑蝥的药用研究进展及资源开发 总被引:3,自引:0,他引:3
斑蝥属昆虫纲鞘翅目芫菁科。在《中华人民共和国药典》(1985)中规定的药用斑蝥有2种,即南方大斑蝥MylabrisphalerataPallas和黄黑小斑蝥M.cichoriiL。由于这一类昆虫的成虫和幼虫体内均含有斑蝥素,药用功效基本相同,因此习惯上也把芫菁科昆虫通称为斑蝥。它是一类重要的药用昆虫。《神农本草经》中就有“斑蝥能治疗痈疽、溃疡、癣疮”等病症的记载。《名医别录》中又记录了“芫菁”、“葛上亭长”两种与斑蝥同功效的昆虫。《本草纲目》中也详细地记述了斑蝥、地胆、芫菁、葛上亭长等4种同类昆虫的形态、生境、采集炮制方法、气味、… 相似文献
10.
目的:探讨CLCA1在结肠癌组织中的表达水平及其与肿瘤进展和预后的关系。方法:随机选取西安交通大学第一附属医院及第四军医大学西京医院行手术切除的临床结肠癌病例239例,应用免疫组织化学方法检测结肠癌组织及癌旁组织中CLCA1的表达情况,使用统计学方法分析CLCA1在结肠癌中的表达与肿瘤临床病理特征及预后的相关性。结果:CLCA1 在肿瘤中的表达较癌旁组织显著降低(P<0.05),CLCA1在结肠癌中表达与原发肿瘤浸润深度、淋巴转移和肿瘤TNM分期显著相关(P<0.05),而且CLCA1低表达组患者总体生存期较高表达组显著缩短(P<0.001),多因素分析显示CLCA1的表达可作为结肠癌的独立预后因素。结论:CLCA1在结肠癌中表达下调,CLCA1的低表达与肿瘤的侵袭转移和临床预后密切相关,有望作为结肠癌个体化治疗靶点。 相似文献