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排序方式: 共有92条查询结果,搜索用时 15 毫秒
1.
A Miller A Khosla J Lynch J Moreb S Cullins H Safah C Hutchison V La Russa Veins J Rice N Mendenhall R Weiner 《Medical oncology (Northwood, London, England)》1998,15(2):89-95
We treated 20 women with locally advanced breast cancer between January 1991 and September 1996, The treatment regimen included
4 cycles of intensive doxorubicin (30 mg/m2/ d on 3 consecutive days every 2 weeks with G-CSF support), followed by appropriate
surgery, followed by high dose therapy with cyclophosphamide, carboplatin and thiotepa (STAMP V, CTCb). Of the 20 patients,
seven presented with inflammatory breast cancer, three with Stage HIB, seven with stage IIIA, one with multifocal Stage IIB
and two with Stage IV M1 (ipsilateral supraclavicular lymph node involvement) (including one who had an inflammatory primary)
disease. Six patients had not undergone mastectomy at the time of entering the protocol. These six received the doxorubicin
in a neoadjuvant fashion and were thus evaluable for tumor response. The remaining 14 received doxorubicin as adjuvant therapy
prior to intensification and transplantation. All patients underwent local-regional radiation therapy and were placed on oral
tamoxifen. Doxorubicin was well tolerated in this schedule with ali but three patients receiving all their cycles on schedule.
Both BM and PBPC were easily collected after this regimen and, when reinfused, resulted in the prompt recovery of granulocytes
(median 11 days to 500 absolute granulocyte count) and platelets (median 13 days to 20000 platelets). The six patients who
received doxorubicin prior to mastectomy all had major clinical responses, but were found to have microscopic focii of breast
cancer in the mastectomy specimens. The overall treatment was well tolerated with the exception of one treatment-related death
(5%). The overall and relapse free survival are 70% and 58% respectively with a median follow-up of 40 months (range 12–74
months). When the Stage IV patients are censored, the relapse-free survival rate is 69%. In the bone marrow transplant phase
of treatment, the major non-hematologic toxicities were stomatitis (70%) and anorexia requiring parental nutrition (75%). 相似文献
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Birth defect-related demise is mainly due to congenital heart defects. In the earlier stage of pregnancy, fetus problem can be identified by finding information about the fetus to avoid stillbirths. The gold standard used to monitor the health status of the fetus is by Cardiotachography(CTG), cannot be used for long durations and continuous monitoring. There is a need for continuous and long duration monitoring of fetal ECG signals to study the progressive health status of the fetus using portable devices. The non-invasive method of electrocardiogram recording is one of the best method used to diagnose fetal cardiac problem rather than the invasive methods.The monitoring of the fECG requires development of a miniaturized hardware and a efficient signal processing algorithms to extract the fECG embedded in the mother ECG. The paper discusses a prototype hardware developed to monitor and record the raw mother ECG signal containing the fECG and a signal processing algorithm to extract the fetal Electro Cardiogram signal. We have proposed two methods of signal processing, first is based on the Least Mean Square (LMS) Adaptive Noise Cancellation technique and the other method is based on the Wavelet Transformation technique. A prototype hardware was designed and developed to acquire the raw ECG signal containing the mother and fetal ECG and the signal processing techniques were used to eliminate the noises and extract the fetal ECG and the fetal Heart Rate Variability was studied. Both the methods were evaluated with the signal acquired from a fetal ECG simulator, from the Physionet database and that acquired from the subject. Both the methods are evaluated by finding heart rate and its variability, amplitude spectrum and mean value of extracted fetal ECG. Also the accuracy, sensitivity and positive predictive value are also determined for fetal QRS detection technique. In this paper adaptive filtering technique uses Sign-sign LMS algorithm and wavelet techniques with Daubechies wavelet, employed along with de noising techniques for the extraction of fetal Electrocardiogram.Both the methods are having good sensitivity and accuracy. In adaptive method the sensitivity is 96.83, accuracy 89.87, wavelet sensitivity is 95.97 and accuracy is 88.5. Additionally, time domain parameters from the plot of heart rate variability of mother and fetus are analyzed. 相似文献
5.
Transdermal estradiol with oral progestin: biological and clinical effects in younger and older postmenopausal women. 总被引:1,自引:0,他引:1
M F Bellantoni S M Harman V E Cullins S M Engelhardt M R Blackman 《Journal of gerontology》1991,46(6):M216-M222
The purpose of this study was to compare the biochemical and clinical effects of transdermal estrogen replacement therapy (tERT) in younger and older postmenopausal women. We treated 15 younger (less than 60 y) and 13 older (greater than or equal to 60 y) healthy postmenopausal women (45-72 y) with four successive 8-week regimens of tERT at doses of 0 to 150 micrograms/day, combined with cyclic oral medroxyprogesterone acetate (MPA). In both age groups, there were similar (p = .0001) dose-responsive increases in plasma estrogen levels and decreases in LH and FSH levels, although LH values were lower in older women both before and after tERT (p less than .02). The addition of MPA further suppressed LH and, to a lesser extent, FSH in both younger and older women. The ratio of estrogenized to nonestrogenized vaginal cells increased with tERT (p less than .007) in both age groups, but significant symptomatic improvement of vaginal irritation was noted only at the highest tERT dose. Adverse effects unrelated to age included short-term nausea in 4/28 women, and skin irritation at the patch sites in 20/28 women. Vaginal bleeding was of shorter duration, but breast tenderness was more common in older women. Further studies of long-term tERT effects in elderly women are indicated. 相似文献
6.
Colin VE Powell 《Journal of paediatrics and child health》2016,52(2):187-191
Acute exacerbations of asthma are very common reasons for a presentation to emergency departments. This paper focuses on defining the high‐risk group, consideration of the concept of phenotypes of acute asthma, the assessment of severe and life‐threatening exacerbations and an emphasis on the management of the more severe end of the exacerbation severity. A number of evidence‐based guidelines exist throughout the world and are all slightly different. This reflects the poor evidence base for some of those recommendations. Thus, a large variation of treatment drugs, doses and regimen are used and clearly not standardised. This paper aims to present a summary of the best evidence and discuss some of these controversies. The most important aspect of treating an exacerbation of acute asthma is to review regularly and assess response to treatment. Severe and life‐threatening episodes should be treated with early use of intravenous treatment in a stepwise manner following the local guidelines. Non‐invasive ventilation and high flow nasal cannulae delivery of oxygen in the emergency department are evolving modalities, but evidence for their use is currently limited. 相似文献
7.
ELIZABETH MENU GRARD CHAOUAT RADOSLAV KINSKY GENEVIVE DELAGE MILJENCO KAPOVIC M.N. THANG CHRISTIAN JAULIN PHILIPPE KOURILSKY THOMAS G. WEGMANN 《American journal of reproductive immunology (New York, N.Y. : 1989)》1995,33(2):200-211
METHOD : It is possible to induce increased fetal resorption in a number of inbred murine matings by injecting Poly (I) Poly (C12U) 3.5 days postconception, a maneuver associated with natural killer-mediated damage to the feto placental unit such as occurs in spontaneous fetal resorptions. RESULTS : We show here that alloimmunization can block this effect. In addition, maternal immune responses induced by alloimmunization against isolated mutant class I or class II, as well as by immunization with class I MHC alloantigens (Kd) transfected L cells are sufficient to restore normal fetal viability. It is not necessary that the maternal immune response be specifically directed against paternal alloantigens fr the fetal protecton to ensue, since the effect occurs in inbred matings when the mother is immunized against unrelated class I or class II alloantigens. As in previous studies conducted in the murine species, not all MHC alloimmunizations are protective. In addition, as control, immunization with a monomorphic class I MHC molecular (37), transfected L cells, sheep red blood cells or hen egg lysozyme is without effect. CONCLUSION : These results indicate that defined MHC antigens can mediate fetal protection from induced fetal resorption, and suggest that one driving force in promoting MHC antigen polymorphism in mammals is their capacity to confer protection from NK mediated fetal demise. 相似文献
8.
NADIR SAOUDI GENEVIÉVE DERUMEAUX ALAIN CRIBIER BRICE LETAC 《Pacing and clinical electrophysiology : PACE》1991,14(11):2022-2027
Several attempts at circuit interruption of type 1 atrial flutter by means of surgical or catheter techniques have been published. We recently reported the results of a series of patients who underwent catheter fulguration of the low septal right atrium, with a mean follow-up of almost 3 years. True electrophysiological success was observed in 7/14 patients (50%). Clinical success, defined as absence of symptoms, was observed in 8/14 (57%) in this patient population. No serious complications were encountered, but the potential risks of DC shock, and the experience that we gained in right atrial mapping using this approach, led us to reconsider the role of atrial DC ablation in these patients. Additional studies assessing the meaning of fragmented electrograms, and identification of one for of severall slow conduction areas of the reentrant circuit are ongoing. 相似文献
9.
Bo Tang Jing Zhou Jeoung-Eun Park David Cullins Ae-Kyung Yi Andrew H. Kang John M. Stuart Linda K. Myers 《Clinical immunology (Orlando, Fla.)》2009,133(1):145-153
We have previously described an analog peptide of type II collagen (CII) that can suppress collagen-induced arthritis (CIA). This analog peptide represents CII245–270, the immunodominant epitope of CII, but with substitutions at 260, 261, and 263 — CII245–270 (A260, B261, and N263) (A9). To elucidate the mechanisms responsible for suppression, we used mice transgenic for a collagen-specific T cell receptor (TCR). When we found that APCs pulsed with A9 failed to induce T cell phosphorylation of TCR-ζ and ZAP-70, we explored alternative signaling pathways. We determined that A9 instead induced phosphorylation of spleen tyrosine kinase (Syk). The importance of Syk was confirmed by the use of chemical Syk inhibitors, which blocked both cytokine secretion and activation of GATA-3 mediated by peptide A9. In summary, T cells use an alternative pathway in response to A9 that involves Syk. This novel T cell pathway may represent an important means for altering T cell phenotypes. 相似文献
10.
Effectiveness of medical abortion with mifepristone and buccal misoprostol through 59 gestational days 总被引:1,自引:1,他引:0
Mary Fjerstad Irving Sivin E. Steve Lichtenberg James Trussell Kelly Cleland Vanessa Cullins 《Contraception》2009,80(3):282-286