全文获取类型
收费全文 | 59260篇 |
免费 | 5332篇 |
国内免费 | 2006篇 |
专业分类
耳鼻咽喉 | 656篇 |
儿科学 | 709篇 |
妇产科学 | 1183篇 |
基础医学 | 8867篇 |
口腔科学 | 1509篇 |
临床医学 | 5239篇 |
内科学 | 10946篇 |
皮肤病学 | 1060篇 |
神经病学 | 4012篇 |
特种医学 | 1985篇 |
外国民族医学 | 7篇 |
外科学 | 7897篇 |
综合类 | 5503篇 |
现状与发展 | 1篇 |
一般理论 | 9篇 |
预防医学 | 3655篇 |
眼科学 | 1546篇 |
药学 | 5496篇 |
7篇 | |
中国医学 | 1443篇 |
肿瘤学 | 4868篇 |
出版年
2023年 | 345篇 |
2022年 | 698篇 |
2021年 | 1078篇 |
2020年 | 752篇 |
2019年 | 914篇 |
2018年 | 1453篇 |
2017年 | 1176篇 |
2016年 | 1121篇 |
2015年 | 1337篇 |
2014年 | 1720篇 |
2013年 | 2009篇 |
2012年 | 2776篇 |
2011年 | 2693篇 |
2010年 | 1628篇 |
2009年 | 1561篇 |
2008年 | 2237篇 |
2007年 | 2342篇 |
2006年 | 2079篇 |
2005年 | 1773篇 |
2004年 | 1547篇 |
2003年 | 1509篇 |
2002年 | 1418篇 |
2001年 | 4753篇 |
2000年 | 4627篇 |
1999年 | 4006篇 |
1998年 | 1432篇 |
1997年 | 1055篇 |
1996年 | 662篇 |
1995年 | 538篇 |
1994年 | 479篇 |
1993年 | 428篇 |
1992年 | 1965篇 |
1991年 | 1697篇 |
1990年 | 1539篇 |
1989年 | 1501篇 |
1988年 | 1317篇 |
1987年 | 1199篇 |
1986年 | 1078篇 |
1985年 | 902篇 |
1984年 | 589篇 |
1983年 | 467篇 |
1982年 | 253篇 |
1981年 | 180篇 |
1980年 | 141篇 |
1979年 | 282篇 |
1978年 | 78篇 |
1976年 | 67篇 |
1974年 | 75篇 |
1973年 | 95篇 |
1972年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
1.
目的 探讨不同年龄阿尔茨海默病(AD)患者ADC值与年龄的相关性。方法 选取30例AD患者(AD组)和年龄与之相匹配的30名志愿者(对照组),按年龄段各分为6个亚组[55~59岁(n=3)、60~64岁(n=4)、65~70岁(n=9)、71~74岁(n=5)、75~80岁(n=6)、>80岁(n=3)],测量双侧海马、红核、尾状核、杏仁体、壳核ADC值,并进行配对t检验、独立样本t检验、单因素方差分析及Pearson相关分析。结果 AD组红核左、右侧ADC值有统计学差异(P=0.022)。AD组不同年龄亚组右侧海马、双侧尾状核、右侧壳核ADC值差异有统计学意义(P均<0.05);2组不同年龄亚组双侧海马、壳核、尾状核ADC值差异有统计学意义(P均<0.05)。AD组右侧海马(r=0.615,P<0.001)、右侧壳核(r=0.653,P=0.001)及双侧尾状核(左侧:r=0.397,P=0.030;右侧:r=0.429,P=0.020)ADC值与年龄呈正相关。结论 AD患者右侧海马和壳核、双侧尾状核ADC值随年龄增加而增大。ADC值可为临床预测和早期诊断AD脑内右侧海马和壳核、双侧尾状核神经退行性病变提供参考。 相似文献
2.
M.F. Werner A. López-Rueda F.X. Zarco J. Blasco L. San Román S. Amaro E. Carrero R. Valero L. Oleaga J.M. Macho N. Bargalló 《Radiologia》2019,61(2):143-152
Purpose
Endovascular treatment with mechanical thrombectomy devices demonstrated high recanalization rates but functional outcome did not correlate with high rates of recanalization obtained. Patient selection prior to the endovascular treatment is very important in the final outcome of the patient. The primary aim of our study was to evaluate the prognostic value of posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) and Pons-Midbrain Index (PMI) scores in patients with Basilar Artery Occlusion (BAO) treated with successful angiographic recanalization after mechanical thrombectomy.Methods
Retrospective single-center study including 18 patients between 2008 and 2013 who had acute basilar artery occlusion managed with endovascular treatment within 24 hours from symptoms onset and with successful angiographic recanalization. The patients were initially classified into two groups according to clinical outcome and mortality at 90 days. For analysis we also divided patients into groups based on pc-ASPECTS (≥8vs.< 8) and PMI (≥3vs.< 3) on non-contrast CT (NCCT) and CT Angiography Source Images (CTASI). Imaging data were correlated to clinical outcome and mortality rate.Results
CTASI pc-ASPECTS, dichotomized at < 8 versus≥8, was associated with a favorable outcome (RR: 2.6; 95% CI: 1.3-5.2) and a reduced risk of death (RR: 6.5: 95% CI: 7.8-23.3). All patients that survived and were functionally independent had pc-ASPECTS score≥8. None of the 5 patients with CTASI pc-ASPECTS score less than 8 survived.Conclusion
PC-ASPECTS on CTASI is helpful for predicting functional outcome after BAO recanalization with endovascular treatment. These results should be validated in a randomized controlled trial in order to decide whether or not to treat a patient with BAO. 相似文献3.
4.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
5.
目的调查镇江市各医院护士分层培训及分层进阶的方法及现状。方法2018年4—5月间采用自行设计的调查问卷,对全市医院的护理人员进行随机抽样调查。结果调查显示镇江市96.45%的护士受医院分层培训及分层进阶这一模式的管理。其中N1占16.77%,N2占29.5%,N3占41.9%,N4占8.7%,其他占3.11%。有24.53%的护士对医院目前的分层培训方式感到满意并认为无需改进,40.99%的护士表示满意,但需要改进,29.19%的护士表示基本满意,需要改进,5.28%的护士表示不满意需要较大改进。95.82%的医院科室对不用层级的护士有不同的核心能力要求并根据不同核心能力要求进行培训。结论护士分层培训几分层进阶这一管理模式在镇江各医院都有体现,但各医院实行的方式有较大差异,配套的管理方式也有待完善。 相似文献
6.
L.‐Q. Zheng X.‐C. Han Y. Huang H.‐W. Li X.‐D. Niu J. Li 《Clinical and experimental dermatology》2015,40(3):293-297
Porocarcinoma is an unusual, locally aggressive and potentially fatal neoplasm. Several cutaneous malignancies have been described in association with porocarcinoma, including squamous cell carcinoma, basal cell carcinoma and tricholemmal carcinoma. Previous reports have indicated that the occurrence of malignant tumours in combination with porocarcinoma is extremely rare, in particular with regard to Bowen disease (BD). We report an uncommon case of porocarcinoma occurring synchronously in a single BD lesion in a 63‐year‐old woman with multiple BD lesions. The clinical and histological findings confirmed this diagnosis. 相似文献
7.
8.
Widely Metastatic Squamous Cell Carcinoma Originating from Malignant Transformation of Hypertrophic Lichen Planus in a 24‐Year‐Old Woman: Case Report and Review of the Literature 下载免费PDF全文
Lana X. Tong B.A. Matthew J. Weinstock M.D. Reed Drews M.D. Caroline C. Kim M.D. 《Pediatric dermatology》2015,32(3):e98-e101
Hypertrophic lichen planus (HLP) is a T‐cell‐mediated process typically presenting with hypertrophic or verrucous plaques on the lower limbs. We report the case of a 24‐year‐old woman with a history of HLP since age 3 years presenting with rapid malignant transformation of one lesion into a large squamous cell carcinoma (SCC). Subsequent examination revealed progressive, widespread metastatic involvement, and the patient ultimately died from her disease. SCC associated with HLP is rare, with a review of the literature revealing fewer than 50 cases. This case highlights the need to be aware of suspicious changes in HLP and to educate patients as to when to be reevaluated. 相似文献
9.
10.
经脉包括经(气)络和血(脉)络,清代周学海《读医随笔》将气络末端称为"气之细络",脉络末端称为"血之细络"。心之气络涵盖心脏起搏与传导系统等广泛调控机制,心之脉络涵盖冠状动脉循环系统,心之气络与脉络相互协调,营卫相偕而行,共同维持心脏正常功能。各种致病因素导致营卫异常而发为心律失常,基于脉络学说营卫理论"损其心者,调其营卫"(《难经·十四难》)治疗原则指导心律失常辨证论治,同时充分结合现代致病因素和致病特点,分别选用调节卫气营血之方药,标本兼治,以期为临床诊疗提供有益借鉴。 相似文献