全文获取类型
收费全文 | 459篇 |
免费 | 21篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 3篇 |
基础医学 | 52篇 |
口腔科学 | 10篇 |
临床医学 | 54篇 |
内科学 | 74篇 |
皮肤病学 | 2篇 |
神经病学 | 22篇 |
特种医学 | 17篇 |
外科学 | 34篇 |
综合类 | 4篇 |
预防医学 | 57篇 |
眼科学 | 72篇 |
药学 | 30篇 |
中国医学 | 7篇 |
肿瘤学 | 32篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 5篇 |
2018年 | 8篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 12篇 |
2014年 | 12篇 |
2013年 | 20篇 |
2012年 | 28篇 |
2011年 | 32篇 |
2010年 | 18篇 |
2009年 | 11篇 |
2008年 | 33篇 |
2007年 | 30篇 |
2006年 | 37篇 |
2005年 | 51篇 |
2004年 | 22篇 |
2003年 | 19篇 |
2002年 | 30篇 |
2001年 | 7篇 |
2000年 | 11篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 6篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有481条查询结果,搜索用时 0 毫秒
1.
2.
Beverly J. White Clare Crandall Jaap Goudsmit Chuck H. Morrow David W. Alling D. Carleton Gajdusek J -H. Tijio John M. Opitz 《American journal of medical genetics. Part A》1981,10(1):77-89
We present cytogenetic findings in 7 familial and 5 sporadic Alzheimer disease (AD) patients and 34 unaffected relatives, spouses, and normal controls. Our study was prompted by reports of increased chromosome abnormalities in patients and family members at risk for AD. Coded peripheral blood chromosome preparations were evaluated for aneuploidy, aberration rates, and banding patterns. Statistical analyses of our results showed no increase in aneuploidy or aberrations in AD patients, their relatives, or normals. Chromosome loss or gain in aneuploid cells was not specific except in two individuals. These two older persons studied, one with AD and one unaffected, were observed to have increased sex chromosome aneuploidy. This finding was attributed to aging and was not considered to be an effect of AD. 相似文献
3.
4.
5.
Slade M Taber D Clarke MM Johnson C Kapoor D Leikin JB Naylor M Neal DA Novak J Steiner D Temkin T Teodo P Tippy A Tronc V Yohanna D Zehr E Zun L;Illinois Hospital Association Behavioral Health Constituency Section Steering Committee its Best Practices Task Force 《Disease-a-month : DM》2007,53(11-12):536-580
6.
R S Chuck C R Cantor D B Tse 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(13):5021-5025
CD4 and T-cell antigen receptor (TCR) comodulate from the surface of human and murine T cells following exposure to monoclonal anti-CD4 or anti-TCR. This comodulation may occur because expression of CD4 and TCR is regulated by similar transmembrane signals or because CD4 and TCR are physically associated. To study multimolecular assemblies on the plasma membrane, we developed a flow cytometric method for detecting singlet-singlet energy transfer between fluorescein isothiocyanate (FITC)- and tetramethylrhodamine isothiocyanate (TRITC)-conjugated monoclonal antibodies as sensitized TRITC emission on intact, single cells. Using this procedure, we detected CD4-TCR complexes on the surface of the transformed human leukemia T cells, HPB-ALL, in the absence of stimulation. More than one CD4 were found in association with one TCR. CD4-TCR complexes were not in rapid equilibrium with free CD4 and free TCR, and they were not induced by the dye-labeled anti-CD4 or anti-TCR. 相似文献
7.
8.
Caroline E. Sheppard Erica L. W. Lester Anderson W. Chuck David H. Kim Shahzeer Karmali Christopher J. de Gara Daniel W. Birch 《Surgical endoscopy》2014,28(12):3329-3336
Introduction
The objective of this study was to determine the short-term cost impact that medical tourism for bariatric surgery has on a public healthcare system. Due to long wait times for bariatric surgery services, Canadians are venturing to private clinics in other provinces/countries. Postoperative care in this population not only burdens the provincial health system with intervention costs required for complicated patients, but may also impact resources allotted to patients in the public clinic.Methods
A chart review was performed from January 2009 to June 2013, which identified 62 medical tourists requiring costly interventions related to bariatric surgery. Secondarily, a survey was conducted to estimate the frequency of bariatric medical tourists presenting to general surgeons in Alberta, necessary interventions, and associated costs. A threshold analysis was used to compare costs of medical tourism to those from our institution.Results
A conservative cost estimate of $1.8 million CAD was calculated for all interventions in 62 medical tourists. The survey established that 25 Albertan general surgeons consulted 59 medical tourists per year: a cost of approximately $1 million CAD. Medical tourism was calculated to require a complication rate ≤28 % (average intervention cost of $37,000 per patient) to equate the cost of locally conducted surgery: a rate less than the current supported evidence. Conducting 250 primary bariatric surgeries in Alberta is approximately $1.9 million less than the modeled cost of treating 250 medical tourists returning to Alberta.Conclusions
Medical tourism has a substantial impact on healthcare costs in Alberta. When compared to bariatric medical tourists, the complication rate for locally conducted surgery is less, and the cost of managing the complications is also much less. Therefore, we conclude that it is a better use of resources to conduct bariatric surgery for Albertan residents in Alberta than to fund patients to seek surgery out of province/country. 相似文献9.
10.