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Xiaoxuan Liu Ameenat L. Solebo Livia Faes Sophie Beese Tasanee Braithwaite Matthew E. Round 《Ocular immunology and inflammation》2020,28(6):898-907
ABSTRACT
Purpose
New instrument-based techniques for anterior chamber (AC) cell counting can offer automation and objectivity above clinician assessment. This review aims to identify such instruments and its correlation with clinician estimates. 相似文献4.
In mycelia of Streptomyces granaticolor grown in liquid cultures the distribution of DNA was surveyed by staining and autoradiographic methods. The frequency of stained nucleoids was rather similar in young and old hyphal regions. However, the size of the nucleoids increased with the age of a hyphal region. The degree of heterogeneity in nucleoid size was particularly high during slow growth. In the autoradiograms silver grains (3H-thymidine label) were also heterogeneously distributed along the hyphae. Calculation of the average number of silver grains per nucleoid revealed that the amount of DNA per nucleoid was 1.6 times higher in the more distant subapical regions than within the 35 μm long apical region. From a chase experiment it became obvious that the DNA segregated in a normal manner only within the apical region. When the chase lasted for one doubling time, the frequency of silver grains was reduced to 50% only within the about 30 μm long apical region. The label incorporated subapieally remained almost constant, therefore, indicating a lack of normal segregation. Only about 10% of the label was lost by branching. The lack of segregation of sister nucleoids after repeated rounds of replication was found to be responsible for the increase of nucleoid size within subapieal hyphal regions. 相似文献
5.
T. J. C. Faes G. A. Yff O. De Weerdt P. Lanting J. J. Heimans F. W. Bertelsmann 《Journal of neurology》1993,240(3):156-160
To evaluate the effects of the aldose reductase inhibitor Ponalrestat (Statil) on diabetic autonomic neuropathy, a double-blind placebo controlled trial was carried out on a group of 34 diabetic patients with documented cardiac autonomic neuropathy. After a 4-week, placebo run-in period, patients were randomised for treatment with 600 mg Statil or placebo for another 24 weeks. Moreover, the reliability of the autonomic nerve function tests was investigated by comparing the results at onset and at week 4. Fifteen patients treated with Statil and 12 with placebo completed the study. Neither symptom scores nor cardiovascular reflexes, pupil reflexes and skin vasomotor reflexes improved after Statil therapy, which led us to conclude that Statil is not effective in the treatment of diabetic autonomic neuropathy. Reliability coefficients for cardiovascular reflexes and pupil reflex showed high values, ranging from 60% to 80%. Therefore these methods are recommended in future therapy trials. 相似文献
6.
Christel Hinteregger Andreas Ferschl Michael Loidl Franz Streichsbier 《Journal of basic microbiology》1993,33(5):301-309
Two distinct muconate cycloisomerases are involved in the degradation of aniline and 3-chloroaniline (3-CA) proceeding via the ortho-cleavage pathways in Pseudomonas acidovorans CA28. After partial purification of these two enzymes kinetic investigations resulted in a clear differentiation of aniline-derived muconate cycloisomerase (MC) and 3-CA-derived chloromuconate cycloisomerase (CMC). A further result of this study revealed the simultaneous coexistence of MC and CMC in strain CA28 when grown on a mixture of aniline and 3-CA. 相似文献
7.
P S Christel 《Clinical orthopaedics and related research》1992,(282):10-18
This article reviews the knowledge about biocompatibility of alumina since its introduction as a material for use in joint replacements. Alumina is a hydrophilic material with high wettability allowing very low friction with negligible wear. Macrophages loaded with alumina particles show no morphologic alteration and do not lose their chemotactic ability. The host response has been studied for bulk and particulate alumina in soft tissues, as well as in human and animal bone under loaded and nonloaded conditions. The soft-tissue response to bulk alumina exhibits minimal fibrosis, and direct bone contact is achieved at compression-loaded interfaces. Examination of human biopsies from failed total hip prostheses reveals a foreign-body reaction containing predominantly macrophages loaded with alumina particles. No lymphocyte or plasma-cell infiltration is observed because of the absence of soluble component release. The amount of necrosis and fibrosis was lower than that associated with metal or polyethylene debris. In summary, alumina exhibits greater bioinertness than all other implant materials currently available for joint replacement. 相似文献
8.
Zum Thema
Die Endoskopie hat in der operativen Gyn?kologie in den letzten Jahren zunehmend an Bedeutung gewonnen. Neben ihrem Einsatz
in der Diagnostik werden auch operativ-therapeutische Eingriffe immer h?ufiger endoskopisch vorgenommen. In vielen F?llen
kann dadurch eine Laparotomie mit ihren Risiken und postoperativen Problemen und der damit verbundenen l?ngeren postoperativen
Hospitalisation vermieden werden.
Auch bei endoskopischen Eingriffen k?nnen schwerwiegende operative Komplikationen auftreten wie z. B. Blutungen oder Verletzungen
von Nachbarorganen wie Darm, Blase, Ureter, Magen [8, 16, 17, 21].
Darüber hinaus kommt es durch die Anlage des Pneumoperitoneums und die Lagerung der Patientinnen bei der Laparoskopie und
durch den Einsatz von Spüll?sungen bei der operativen Hysteroskopie zu pathophysiologischen Ver?nderungen, deren Kenntnis
für Operateur und An?sthesist zur Vermeidung von Komplikationen unabdingbar ist [18, 25]. 相似文献
9.
10.
High prevalence of hepatitis C virus type 5 in central France evidenced by a prospective study from 1996 to 2002
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Henquell C Cartau C Abergel A Laurichesse H Regagnon C De Champs C Bailly JL Peigue-Lafeuille H 《Journal of clinical microbiology》2004,42(7):3030-3035
From 1996 to 2002, hepatitis C virus (HCV) typing was prospectively performed for 1,281 unselected HCV-infected and viremic patients, irrespective of their clinical status. Eighty-three patients (6.5%) were coinfected with human immunodeficiency virus (HIV) and HCV. A total of 1,195 strains were identified by a serotype screening (Murex HCV Serotyping 1-6 assay) and/or genotyping (Inno-LiPA HCV II) test. The distribution of HCV types showed an unusually high rate of type 5 (14.2%) that was stable over time and was the third most frequent type, after type 1 (59.1%) and type 3 (15.1%). HCV type 5 was more frequent in patients who were older than 50 (P = 10(-6)), but its frequency did not differ significantly by gender (P = 0.21). Serotyping was performed for 1,160 strains but failed for 30.2% of them. The efficiency depended on HIV status (for HCV-HIV-coinfected patients, half of the strains were untypeable) and HCV type. Genotyping was performed for 428 samples, with an overall efficiency of 99.3%. It failed in three cases, which were subsequently identified as HCV type 2. Serotyping and genotyping results for 39 patients showed discrepancies between the two methods for 4 patients, who had HCV type 2, type 6, or mixed infections. Thus, HCV type 5 may also be encountered frequently in Western countries. Its apparent confinement to a restricted area raises the question of how it emerged and underscores the need for further studies of HCV type prevalence, routes of transmission, pathogenicity, and responses to treatment. 相似文献