全文获取类型
收费全文 | 1656篇 |
免费 | 96篇 |
国内免费 | 114篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 74篇 |
妇产科学 | 38篇 |
基础医学 | 181篇 |
口腔科学 | 28篇 |
临床医学 | 178篇 |
内科学 | 427篇 |
皮肤病学 | 44篇 |
神经病学 | 72篇 |
特种医学 | 364篇 |
外国民族医学 | 1篇 |
外科学 | 97篇 |
综合类 | 40篇 |
预防医学 | 101篇 |
眼科学 | 27篇 |
药学 | 111篇 |
中国医学 | 8篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 6篇 |
2021年 | 13篇 |
2020年 | 17篇 |
2019年 | 18篇 |
2018年 | 27篇 |
2017年 | 12篇 |
2016年 | 25篇 |
2015年 | 25篇 |
2014年 | 30篇 |
2013年 | 56篇 |
2012年 | 31篇 |
2011年 | 50篇 |
2010年 | 60篇 |
2009年 | 59篇 |
2008年 | 48篇 |
2007年 | 89篇 |
2006年 | 56篇 |
2005年 | 72篇 |
2004年 | 26篇 |
2003年 | 30篇 |
2002年 | 27篇 |
2001年 | 24篇 |
2000年 | 40篇 |
1999年 | 27篇 |
1998年 | 93篇 |
1997年 | 99篇 |
1996年 | 109篇 |
1995年 | 68篇 |
1994年 | 62篇 |
1993年 | 67篇 |
1992年 | 17篇 |
1991年 | 35篇 |
1990年 | 23篇 |
1989年 | 50篇 |
1988年 | 38篇 |
1987年 | 50篇 |
1986年 | 29篇 |
1985年 | 46篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 25篇 |
1981年 | 20篇 |
1980年 | 30篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1977年 | 17篇 |
1976年 | 26篇 |
1975年 | 16篇 |
1974年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1866条查询结果,搜索用时 15 毫秒
1.
2.
Antonio Gómez Mercedes Salgado Manuel Valladares-Ayerbes Mónica Jorge Ana Carballo Sonia Candamio Pilar Izquierdo Paula Peleteiro Rafael López 《Clinical & translational oncology》2010,12(12):843-848
Objective
The aim of the project was to assess the effectiveness and safety of weekly epoetin-beta (EB) in patients with gastrointestinal cancer (GIC) subjected to concomitant chemoradiotherapy (CCTRT). 相似文献3.
Summary— To investigate if the functional alterations observed in resistance arteries of spontaneously hypertensive rats (SHRs) were also present at the coronary level, in vitro experiments were performed in mesenteric resistance arteries (MRA) and in right (RIC) and left interventricular coronary (LIC) arteries taken from 15–25-week-old SHR and age-matched Wistar Kyoto rats WKYs. Using a passive extension protocol, internal diameters corresponding to 100 mmHg intraluminal pressure (D100) were determined and vessels were set up to a normalized internal diameter (0.9 D100). SHR mesenteric resistance arteries had a significantly smaller diameter compared to WKY arteries, whereas both types of SHR coronary arteries had a greater diameter compared to those of WKY rats. In arteries in the absence of contracting agonist, nitro-L-arginine (NOLA, 100 μM) induced a progressive rise in basal tone, which could be reversed by subsequent addition of L-arginine (100 μM) but not D-arginine (100 μM). When expressed as percent of maximal contractions induced by agonists (noradrenaline, NA [10 μM] in MRA; serotonin, 5-HT [10 μM], in RIC and LIC), these contractions were significantly stronger in WKY compared to SHR coronary and mesenteric resistance arteries. In NA-precontracted MRA and 5HT-precontracted coronary arteries in the presence of indomethacin (10 μM), the magnitude of acetylcholine-induced maximal relaxations (expressed as percent of maximal contractions induced by agonists) was greater in WKY compared to SHR arteries. After a 30-min incubation period, NOLA (100 μM) completely inhibited relaxations induced by acetylcholine (0.01–10 μM) in all types of precontracted arteries. Subsequent additions of sodium nitroprusside, (SNP, 10 μM) induced complete relaxations in all preparations. These results show that a basal release of NO or NO-like compound by endothelial cells is present in isolated mesenteric resistance and coronary arteries of WKY rats and SHRs. The contribution of endothelium-derived relaxing factor-nitric oxide (EDRF-NO) to arterial tone was lower in MRA compared to coronary arteries in both strains and in SHR compared to WKY arteries. In the SHR preparations, the impaired relaxation induced by acetylcholine appeared to be due to a functional alteration of the endothelium in the presence of normal reactivity of the smooth muscle cells. 相似文献
4.
5.
6.
表小檗碱对α受体的作用 总被引:2,自引:0,他引:2
表小檗碱(epiberberine,EB)是从湖北产黄连(Coptis chinensis Franch)中提取的一种生物碱,属苯喹嗪类原小檗碱,对其药理作用的研究资料甚少,未见其对α肾上腺素体作用的报道。资料表明,许多原小檗碱类化合物有α受体阻滞作用,为从该类化合物中选择 相似文献
7.
8.
Leo Sher Juan J Carballo Michael F Grunebaum Ainsley K Burke Gil Zalsman Yung-yu Huang J John Mann Maria A Oquendo 《Bipolar disorders》2006,8(5P2):543-550
Objectives: Bipolar disorder is a severe illness that is associated with suicidal behavior. A biological predictor of highly lethal suicide attempts in patients with bipolar disorder would be valuable. We hypothesized that cerebrospinal fluid (CSF) monoamine metabolite levels are related to lethality of suicide attempts in bipolar patients and examined the relation between CSF 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and maximum lethality of suicide attempts at baseline and during a 2-year follow up.
Methods: Twenty-seven bipolar depressed patients participated in the study. Demographic and clinical parameters were examined and recorded. Lumbar punctures were performed and CSF 5-HIAA, HVA, and MHPG were assayed by high-performance liquid chromatography with electrochemical detection. Following discharge, patients were evaluated after 3 months, 1 year, and 2 years. Each follow-up interview included an in-depth assessment of suicidal behavior during the intervening time period.
Results: Six subjects made suicide attempts during the 2-year follow-up. Bipolar patients who attempted suicide during the follow-up period had higher aggression and hostility scale scores compared to bipolar subjects who did not make a suicide attempt during the follow-up period. CSF 5-HIAA, HVA, and MHPG levels were negatively correlated with the maximum lethality of suicide attempts during the 2-year follow-up period.
Conclusions: Our finding is the first observation that CSF monoamine metabolite levels may be predictors of lethality of suicide attempts in patients with bipolar disorder. Further studies are necessary to answer the question whether CSF monoamine metabolite levels are clinically useful biochemical predictors of highly lethal suicide attempts or completed suicides. 相似文献
Methods: Twenty-seven bipolar depressed patients participated in the study. Demographic and clinical parameters were examined and recorded. Lumbar punctures were performed and CSF 5-HIAA, HVA, and MHPG were assayed by high-performance liquid chromatography with electrochemical detection. Following discharge, patients were evaluated after 3 months, 1 year, and 2 years. Each follow-up interview included an in-depth assessment of suicidal behavior during the intervening time period.
Results: Six subjects made suicide attempts during the 2-year follow-up. Bipolar patients who attempted suicide during the follow-up period had higher aggression and hostility scale scores compared to bipolar subjects who did not make a suicide attempt during the follow-up period. CSF 5-HIAA, HVA, and MHPG levels were negatively correlated with the maximum lethality of suicide attempts during the 2-year follow-up period.
Conclusions: Our finding is the first observation that CSF monoamine metabolite levels may be predictors of lethality of suicide attempts in patients with bipolar disorder. Further studies are necessary to answer the question whether CSF monoamine metabolite levels are clinically useful biochemical predictors of highly lethal suicide attempts or completed suicides. 相似文献
9.
10.