Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy‐Induced Nausea and Vomiting in Children With Cancer

This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy‐induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence‐based interventions for the treatment of breakthrough and prophylaxis of refractory CINV are recommended. Gaps in the evidence used to support the recommendations made in this clinical practice guideline were identified. The contribution of these recommendations to breakthrough and refractory CINV control in children requires prospective evaluation.     

Absent CNKSR2 causes seizures and intellectual,attention, and language deficits

Synaptic function is central to brain function. Understanding the synapse is aided by studies of patients lacking individual synaptic proteins. Common neurological diseases are genetically complex. Their understanding is likewise simplified by studies of less common monogenic forms. We detail the disease caused by absence of the synaptic protein CNKSR2 in 8 patients ranging from 6 to 62 years old. The disease is characterized by intellectual disability, attention problems, and abrupt lifelong language loss following a brief early childhood epilepsy with continuous spike‐waves in sleep. This study describes the phenotype of CNKSR2 deficiency and its involvement in systems underlying common neurological disorders. Ann Neurol 2014;76:758–764     

A feasibility study to assess service providers' perspectives regarding the use of the child and adolescent functional assessment scale in ontario

This brief report describes a feasibility study conducted to assess the level of satisfaction with the Child and Adolescent Functional Assessment Scale (CAFAS) rater reliability training, the ease of achieving interrater reliability in rating CAFAS, and the clinical utility of CAFAS as an outcome measurement tool for the province of Ontario, from the perspective of service providers. This study has been instrumental in the development of a 4-year province-wide measurement initiative. The study proved useful to government policy and decision-makers, mental health administrators, clinicians, and mental health service researchers interested in the implementation of outcome measurement tools. It highlighted the fact that at least 85% of respondents were satisfied with CAFAS training and the ease of achieving interrater reliability. The majority identified the usefulness of the tool in case formulation and the value in tracking changes over time.She is also affiliated with the Department of Psychiatry and the Department of Public Health Sciences at the University of Toronto, Ontario, Canada.He is also affiliated with the Department of Psychiatry, Department of Public Health Sciences, and the Department of Psychology at the University of Toronto, Ontario, Canada.She is also affiliated with the Department of Public Health Sciences at the University of Toronto, Ontario, Canada.     

Drug Use Among a Sample of Males Admitted to an Alcohol Detoxication Center

Urine samples were obtained from 93% of a sample of 111 consecutive male admissions to a nonmedical detoxication center in Toronto. Analysis of these samples revealed that 51 (50%) had traces of drugs other than alcohol and that 12 (12%) were alcohol free. Benzodiazepines were the most frequently detected drugs and these were found in 32% of all samples. Barbiturates were detected in seven (7%) samples and cannabinoids in 10 (10%) samples. A wide range of urine alcohol concentrations was found and some samples had zero or low concentrations. Although alcohol urine concentrations were generally lower in samples containing other drugs, the distribution of urine alcohol concentrations was similar for samples containing only alcohol and those containing alcohol and some other drug. Of the 51 samples found to contain drugs other than alcohol, subjects' self-reports were concordant in 27 cases (53%). Most of the discrepancies between self-reports and urine analysis were due to the under-reporting of the use of benzodiazepines. Subjects with drugs in their urine tended to be younger than others, but they were not distinguished with respect to their behaviors while in the detoxication center or length of stay. Those with the highest urine alcohol concentrations had shorter stays in the detoxication center. Implications for further studies are discussed.     

Career aspirations, job satisfaction and gender identity in female student nurses

This study examines the gender-role orientation, gender-role conflict, job commitment and work motivation of female student nurses in the Republic of Ireland Career aspirations, year of nurse training and geographical area of upbringing were examined as potential concomitants of these dependent measures Subjects completed self-report measures of job involvement, work motivation, gender-role orientation and gender-role conflict Results obtained showed that aspiring towards a traditionally female career area of nursing was associated with higher levels of work motivation and lower levels of gender-role conflict Higher levels of job commitment amongst final year students were also significantly related to traditionally female career aspirations Year of training had a significant and negative influence on work motivation and job commitment Finally, nurses from rural areas aspiring towards a traditionally female area of nursing had significantly more feminine gender-role orientations than either their urban counterparts or rural colleagues with non-traditional career aspirations The theoretical and practical implications of these results are discussed