首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   20098篇
  免费   1694篇
  国内免费   49篇
耳鼻咽喉   188篇
儿科学   743篇
妇产科学   378篇
基础医学   2411篇
口腔科学   423篇
临床医学   2836篇
内科学   3685篇
皮肤病学   197篇
神经病学   2010篇
特种医学   609篇
外科学   2472篇
综合类   434篇
一般理论   24篇
预防医学   2244篇
眼科学   460篇
药学   1468篇
  1篇
中国医学   15篇
肿瘤学   1243篇
  2023年   108篇
  2022年   154篇
  2021年   370篇
  2020年   249篇
  2019年   392篇
  2018年   467篇
  2017年   331篇
  2016年   367篇
  2015年   440篇
  2014年   612篇
  2013年   894篇
  2012年   1311篇
  2011年   1326篇
  2010年   716篇
  2009年   631篇
  2008年   1104篇
  2007年   1198篇
  2006年   1132篇
  2005年   1125篇
  2004年   1091篇
  2003年   931篇
  2002年   956篇
  2001年   393篇
  2000年   378篇
  1999年   361篇
  1998年   233篇
  1997年   186篇
  1996年   168篇
  1995年   148篇
  1994年   155篇
  1993年   169篇
  1992年   313篇
  1991年   263篇
  1990年   233篇
  1989年   210篇
  1988年   204篇
  1987年   203篇
  1986年   187篇
  1985年   179篇
  1984年   143篇
  1983年   124篇
  1982年   118篇
  1981年   108篇
  1980年   114篇
  1979年   101篇
  1978年   94篇
  1977年   88篇
  1976年   93篇
  1973年   101篇
  1972年   89篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
PurposeOur purpose was to determine the effect of chemoradiotherapy (CRT) on patient-reported quality of life (QOL) for patients with intact pancreas cancer.Methods and MaterialsWe reviewed a prospective QOL registry for patients with intact, clinically localized pancreatic ductal adenocarcinoma treated with CRT between June 2015 and November 2018. QOL was assessed pre-CRT (immediately before CRT, after neoadjuvant chemotherapy) and at the completion of CRT with the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) and its component parts: FACT-General (FACT-G) and hepatobiliary cancer subscore (HCS). A minimally important difference from pre-CRT was defined as ≥ 6, 5, and 8 points for FACT-G, HCS, and FACT-Hep, respectively.ResultsOf 157 patients who underwent CRT, 100 completed both pre- and post-CRT surveys and were included in the primary analysis. Median age at diagnosis was 65 years (range, 23-90). National Comprehensive Cancer Network resectability status was resectable (3%), borderline resectable (40%), or locally advanced (57%). Folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) (75%) or gemcitabine and nab-paclitaxel (42%) were given for a median of 6 cycles (range, 0-42) before CRT. Radiation therapy techniques included 3-dimensional conformal (22%), intensity modulated photon (55%), and intensity modulated proton (23%) radiation therapy to a median dose of 50 Gy (range, 36-62.5). Concurrent chemotherapy was most commonly capecitabine (82%). Sixty-three patients (63%) had surgery after CRT. The mean decline in FACT-G, HCS subscale, and FACT-Hep from pre- to post-CRT was 3.5 (standard deviation [SD], 13.7), 1.7 (SD 7.8), and 5.2 (SD 19.4), respectively. Each of these changes were statistically significant, but did not meet the minimally important difference threshold. Pancreatic head tumor location was associated with decline in FACT-Hep. Nausea was the toxicity with the greatest increase from pre- to post-CRT by both physician-assessment and patient-reported QOL.ConclusionsFor patients with intact pancreatic adenocarcinoma, modern CRT is well tolerated with minimal decline in QOL during treatment.  相似文献   
5.
6.
7.
Increasing numbers of arthroplasties are also accompanied by postoperative infections. The main purpose was to evaluate preoperative serum bilirubin levels between patients with and without infections after shoulder and knee arthroplasties. For this retrospective case-control single-center study, a total of 108 patients were extracted from a prospectively collected database. Eighteen patients with infections after shoulder (n = 8) and knee (n = 10) arthroplasty were matched by age, gender, and implant type in a 1:5-scenario to 90 patients (40 shoulders and 50 knees) without postoperative infection. Demographic data, preoperative blood parameters, and postoperative infection-related outcomes were evaluated. Total bilirubin was the only preoperative parameter significantly different between the infection (8.21 ± 3.25 μmol/L or 0.48 ± 0.19 mg/dL) and noninfection (10.78 ± 4.62 μmol/L or 0.63 ± 0.27 mg/dL; P = .014) group, while C-reactive protein and other liver parameters were similar between the groups. Significantly more controls (92.1%) had preoperative bilirubin levels above 8.72 μmol/L or 0.51 mg/dL than cases (7.9%; P = .007). The 5-year infection survival-rate was 65.6% for patients with preoperative bilirubin levels < 8.72 μmol/L or < 0.51 mg/dL and 91.2% with ≥ 8.72 μmol/L or ≥ 0.51 mg/dL. Mildly decreased preoperative bilirubin levels with a cutoff at 8.72 μmol/L or 0.51 mg/dL were significantly associated to patients with infections after shoulder and knee arthroplasty. There were no differences in other blood parameters or comorbidities between patients with infections and their matched-controls.  相似文献   
8.
Marie Warrer Petersen  Tine Sylvest Meyhoff  Marie Helleberg  Maj-Brit Nørregaard Kjær  Anders Granholm  Carl Johan Steensen Hjortsø  Thomas Steen Jensen  Morten Hylander Møller  Peter Buhl Hjortrup  Mik Wetterslev  Gitte Kingo Vesterlund  Lene Russell  Vibeke Lind Jørgensen  Klaus Tjelle  Thomas Benfield  Charlotte Suppli Ulrik  Anne Sofie Andreasen  Thomas Mohr  Morten H. Bestle  Lone Musaeus Poulsen  Mette Friberg Hitz  Thomas Hildebrandt  Lene Surland Knudsen  Anders Møller  Christoffer Grant Sølling  Anne Craveiro Brøchner  Bodil Steen Rasmussen  Henrik Nielsen  Steffen Christensen  Thomas Strøm  Maria Cronhjort  Rebecka Rubenson Wahlin  Stephan Jakob  Luca Cioccari  Balasubramanian Venkatesh  Naomi Hammond  Vivekanand Jha  Sheila Nainan Myatra  Christian Gluud  Theis Lange  Anders Perner 《Acta anaesthesiologica Scandinavica》2020,64(9):1365-1375

Introduction

Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.

Methods

The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving ≥10 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.

Discussion

The COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.
  相似文献   
9.
Objective: M-mode and 2D have been proposed for evaluating fetal myocardial thickness. However, studies comparing the performance of both modalities are lacking. We aimed to compare 2D versus M-mode reproducibility for assessing myocardial wall thicknesses.

Methods: A prospective study including 45 healthy fetuses from low-risk pregnancies evaluated between 18 and 41 weeks of gestation. Left and right ventricular free-wall and septal myocardial thicknesses were measured at end-diastole (ED) and end-systole (ES) in transverse 4-chamber view using 2D and M-mode. Intra- and interobserver reproducibility was evaluated by the concordance correlation coefficient (CCC). Both techniques were compared by t-test of the CCC.

Results: 2D and M-mode demonstrated excellent and similar intraobserver repeatability, with the best concordance in ES septal thickness (M-mode CCC 0.956 versus 2D-mode CCC 0.914). Interobserver reproducibility demonstrated also a high concordance, optimal in ES left ventricular free wall (M-mode 0.925 versus 2 D 0.855). Comparison of both techniques demonstrated a high concordance in all measurements, except for ED septal thickness with better reproducibility using M-mode (CCC 0.954 versus 0.847, p?=?.017).

Conclusions: 2D and M-mode can be used in a reproducible manner for measuring fetal myocardial thickness, with a slightly better performance of M-mode for assessing ED septal wall thickness.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号