Arzneimitteltherapiesicherheit im Krankenhaus

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Arzneimittelbezogene Probleme (ABP) sind eine signifikante und häufig vermeidbare Ursache für Morbidität und...     

Effects of inconspicuous bionocular defects, their diagnosis and suggestions for therapy (author's transl)

Unclear asthenopic complaints are often due to intermittant loss of binocularity. Simple tests are described, based on the characteristic features of physiological binocularity. They can be used to demonstrate an intermittant alternating or unilateral central scotoma which may be the result of the interaction of primarily sensory or primarily motor dysfunctions. Hence particular importance must be attached to using these methods with varying distances and directions of vision. The findings obtained from these tests should be the starting point of therapy.     

Oculo-neural involvement in an enzymatically proven case of Niemann-Pick disease type B

Niemann-Pick disease type B was diagnosed clinically and enzymatically in a 4 years old girl presenting with hepatosplenomegaly, diffuse interstitial infiltrations of both lungs on chest roentgenograms, and foam cells in the bone marrow aspirate. Intelligence and neurological examinations were normal. Spingomyelinase activity was almost totally deficient in leukocytes and cultured skin fibroblasts. Unexpectedly, fundoscopy revealed oculoneural involvement with a reddish-brown spot of the macula comparable to but differing in some respects from the classic cherry-red spot found in neurolipidoses. By definition patients with type B Niemann-Pick disease should have no cerebral or oculo-neural involvement. Two comparable cases have been described in the literature. The prognosis of this special type is not yet known. For classification—and especially for genetic counselling—it seems important to include the possibility of oculo-neural involvement in the diagnosis of Niemann-Pick disease type B.Dedicated to Prof. Dr. E. Willich on the occasion of his 60th birthday