全文获取类型
收费全文 | 1657篇 |
免费 | 79篇 |
国内免费 | 148篇 |
专业分类
儿科学 | 64篇 |
妇产科学 | 6篇 |
基础医学 | 92篇 |
口腔科学 | 18篇 |
临床医学 | 201篇 |
内科学 | 277篇 |
皮肤病学 | 30篇 |
神经病学 | 19篇 |
特种医学 | 308篇 |
外科学 | 37篇 |
综合类 | 24篇 |
预防医学 | 48篇 |
眼科学 | 13篇 |
药学 | 441篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 304篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2020年 | 7篇 |
2019年 | 10篇 |
2018年 | 16篇 |
2017年 | 13篇 |
2016年 | 24篇 |
2015年 | 26篇 |
2014年 | 27篇 |
2013年 | 56篇 |
2012年 | 43篇 |
2011年 | 53篇 |
2010年 | 45篇 |
2009年 | 64篇 |
2008年 | 48篇 |
2007年 | 139篇 |
2006年 | 64篇 |
2005年 | 78篇 |
2004年 | 36篇 |
2003年 | 29篇 |
2002年 | 71篇 |
2001年 | 67篇 |
2000年 | 52篇 |
1999年 | 61篇 |
1998年 | 86篇 |
1997年 | 92篇 |
1996年 | 83篇 |
1995年 | 74篇 |
1994年 | 61篇 |
1993年 | 65篇 |
1992年 | 16篇 |
1991年 | 23篇 |
1990年 | 18篇 |
1989年 | 51篇 |
1988年 | 35篇 |
1987年 | 31篇 |
1986年 | 30篇 |
1985年 | 26篇 |
1984年 | 20篇 |
1983年 | 12篇 |
1982年 | 27篇 |
1981年 | 14篇 |
1980年 | 14篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 16篇 |
1976年 | 28篇 |
1975年 | 13篇 |
排序方式: 共有1884条查询结果,搜索用时 78 毫秒
1.
2.
3.
4.
Adverse reaction to intravenous gadoteridol 总被引:1,自引:0,他引:1
5.
J H Beijnen L T Vlasveld J Wanders W W ten Bokkel Huinink S Rodenhuis 《The Annals of pharmacotherapy》1992,26(4):488-490
OBJECTIVE: A case in which a possible cisplatin interference with lithium pharmacokinetics is evaluated. DATA SYNTHESIS: A 36-year-old woman with disseminated cervical cancer and multiple metastatic lesions in both kidneys was being treated with five courses of bleomycin, vindesine, mitomycin C, and cisplatin. The patient had also been taking lithium carbonate for the management of a manic-depressive disorder. Serum and urinary lithium concentrations were measured daily during the first course of chemotherapy and on a periodic basis during and between the consecutive courses. Lithium concentrations remained within the therapeutic range during the first course and increased later in association with deterioration of the patient's renal function secondary to progressive disease in both kidneys. This required dose adjustments of lithium. CONCLUSIONS: Lithium therapy should be guided by serial serum concentrations in such patients. 相似文献
6.
The chemical stability of members of two groups of cytostatics, mitomycins and anthracyclines, has been studied in four different cell culture media enriched with serum. Stability was determined with the use of high performance liquid chromatography. In the group of mitomycins, the 7-aminomitosanes appeared to be relatively stable during a seven days incubation period at 37 degrees C when compared to the 7-methoxy congeners. The anthracycline derivatives, 4-demethoxy-daunorubicin, doxorubicin and its 4'-analogues showed half-lives of about 10-20 hours. Doxorubicinol and daunorubicin were found to be more stable. Anthracycline degradation products could be traced with the use of thin layer chromatography. All main degradation products originate from hydrolytic reactions. No enzymatic conversions could be observed. These observations may be of importance for the correct interpretation of the effects of mitomycins or anthracyclines on cells incubated in a cell culture medium. 相似文献
7.
8.
9.
Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid. 总被引:1,自引:1,他引:0
下载免费PDF全文
![点击此处可从《Antimicrobial agents and chemotherapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
D M Burger H Rosing C H ten Napel T Duyts P L Meenhorst J W Mulder C H Koks A Bult J H Beijnen 《Antimicrobial agents and chemotherapy》1994,38(12):2763-2767
A specific and sensitive radioimmunoassay for the determination of levels of zalcitabine in human plasma, urine, and cerebrospinal fluid has been developed. Commercially available radiolabel and antiserum (Sigma Chemicals) were used after dilution in assay buffer. Prior to the immunoassay, standard and patient samples were subjected to solid-phase extraction on silica columns in order to obtain purified samples. The lower limit of quantitation was determined to be 1 ng/ml. Intra- and interassay variations were less than 11% for a number of quality control samples of drug in plasma and urine. Results from parallelism studies with plasma and urine demonstrated that samples outside the standard range (1 to 30 ng/ml) could be diluted by blank plasma or assay buffer, respectively. A large number of related compounds and potentially coadministered drugs were tested for cross-reactivity. Stability tests showed that heat treatment for 30 min at 60 degrees C or storage for 1 month at -30 degrees C did not affect zalcitabine concentrations in plasma or urine. The radioimmunoassay with solid-phase extraction for sample cleanup discussed here has been successfully applied in a pharmacokinetic study of a single patient, demonstrating its applicability for clinical pharmacokinetic research with zalcitabine. 相似文献
10.