全文获取类型
收费全文 | 1130篇 |
免费 | 51篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 25篇 |
妇产科学 | 30篇 |
基础医学 | 130篇 |
口腔科学 | 27篇 |
临床医学 | 89篇 |
内科学 | 296篇 |
皮肤病学 | 51篇 |
神经病学 | 77篇 |
特种医学 | 17篇 |
外科学 | 76篇 |
综合类 | 11篇 |
预防医学 | 101篇 |
眼科学 | 42篇 |
药学 | 88篇 |
中国医学 | 5篇 |
肿瘤学 | 110篇 |
出版年
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 4篇 |
2021年 | 23篇 |
2020年 | 9篇 |
2019年 | 22篇 |
2018年 | 49篇 |
2017年 | 40篇 |
2016年 | 34篇 |
2015年 | 36篇 |
2014年 | 41篇 |
2013年 | 69篇 |
2012年 | 125篇 |
2011年 | 135篇 |
2010年 | 51篇 |
2009年 | 36篇 |
2008年 | 77篇 |
2007年 | 71篇 |
2006年 | 83篇 |
2005年 | 64篇 |
2004年 | 66篇 |
2003年 | 56篇 |
2002年 | 47篇 |
2001年 | 9篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1989年 | 5篇 |
1988年 | 1篇 |
1987年 | 5篇 |
1986年 | 4篇 |
排序方式: 共有1184条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Bego?a López Arantxa González Ramón Querejeta Mariano Larman Javier Díez 《Journal of the American College of Cardiology》2006,48(1):89-96
OBJECTIVES: We sought to assess the distribution of collagen deposits and collagen degradation in hypertensive patients with either systolic heart failure (SHF) or diastolic heart failure (DHF). BACKGROUND: Increased collagen synthesis and deposition have been described in the myocardium of heart failure (HF) hypertensive patients. METHODS: We studied 39 HF hypertensive patients subdivided into two groups: 16 with SHF and 23 with DHF. Endomyocardial biopsies were performed to quantify mysial (i.e., perimysial plus endomysial) and perivascular and scar-related collagen volume fraction (CVF). Matrix metalloproteinase (MMP)-1 and its tissue inhibitor matrix metalloproteinase (TIMP)-1 were analyzed in cardiac samples by Western blot and immunohistochemistry, and in blood samples by enzyme-linked immunosorbent assay. RESULTS: Mysial CVF was lower in SHF hypertensive patients than in normotensive (p < 0.05) and DHF hypertensive patients (p < 0.01). Perivascular and scar-related CVF was higher (p < 0.05) in the two groups of hypertensive patients than in normotensive subjects, and in SHF hypertensive compared with DHF hypertensive patients. The MMP-1:TIMP-1 ratio was increased (p < 0.05) in tissue and serum samples from the SHF hypertensive group compared with the other two groups of subjects. The MMP-1 expression was increased (p < 0.01) in the interstitium and cardiomyocytes of SHF hypertensive patients compared with DHF hypertensive and normotensive subjects. The serum MMP-1:TIMP-1 ratio was inversely correlated with ejection fraction (r = -0.510, p < 0.001) and directly correlated with left ventricular end-diastolic diameter (r = 0.549, p < 0.001) in all subjects. CONCLUSIONS: These findings show that the pattern of collagen deposits and the balance of the MMP-1/TIMP-1 system are different in the myocardium of SHF and DHF hypertensive patients. It is proposed that excessive degradation of mysial collagen may be related to the compromise of systolic function in HF hypertensive patients. 相似文献
5.
P Toussaint P Turut S Milazzo S Le Bihan B Bego 《Bulletin des sociétés d'ophtalmologie de France》1989,89(2):267-8, 271-2
4 cases of tilted disc syndrome are reported. Two were associated with sellar or endocrine pathology, one had a particular aspect of chorioretinal atrophy, and the last had a thrombosis of the central vein of retina. The most commonly aspects of tilted disc syndrome are reported. 相似文献
6.
S Milazzo P Turut B Bego E Bryselbout 《Bulletin des sociétés d'ophtalmologie de France》1989,89(12):1413-1417
"Like flows" atrophy of the retinal pigment epithelium are observed in multiple cases of lesions of the posterior pole. The authors are reported one observation of different diseases with like flows atrophy. 相似文献
7.
Emilio Abecia Begoña Martínez-Jarreta Yolanda Casalod Blanca Bell Isabel Pinilla Francisco M. Honrubia 《International ophthalmology》1996,20(1-3):79-82
Purpose: To investigate possible associations between genetic markers and Primary Open-Angle Glaucoma (POAG). Methods: A number of genetic markers were typed in 84 unrelated patients with POAG and compared with a random sample of healthy individuals. The markers were Transferrin, Group Specific Component, G1m (1), G1m (2) and G3m (5) Allotypes, Adenylate Kinase, Adenosin Deaminase, Glyoxalase I and Acid Phosphatase and PCR-based markers HLA-DQA1 and D1S80. Results: No significant differences were found except the strong association between the group of POAG patients and Acid Phosphatase ACP*C allele (2 = 32.86; p < 0.0001). Conclusions: Since Acid Phosphatase gene is localized to chromosome 2p23, this result could be a first comprehensive step in the localization of POAG genes. 相似文献
8.
Alejandro Vázquez-Martín Cristina Oliveras-Ferraros Sonia del Barco Begoña Martín-Castillo Javier A. Menéndez 《Clinical & translational oncology》2009,11(7):455-459
The small molecule HER2 tyrosine kinase inhibitor (TKI) lapatinib (Tykerb®) is approved for the therapy of patients with HER2-positive breast carcinomas who have progressed on trastuzumab (Herceptin®). Unfortunately, the efficacy of this HER2 TKI is limited by both primary (inherent) and acquired resistance, the latter typically occurring within 12 months of starting therapy. One of the key factors limiting our understanding of the mechanisms involved in lapatinib resistance is the lack of published preclinical models. We herein review lapatinib-refractory models recently developed at the bench and the survival pathways discovered. As hyperactivation of the pharmacologically targetable PI3K/mTOR/p70S6K1 axis appears to be central to the occurrence of lapatinib resistance, preclinical data showing enhanced antitumour effects when combining lapatinib with mTOR inhibitors (e.g., rapamycin analogues and NVP-BEZ235) highlight the importance of translational work to yield clinically useful regimens capable of delaying or treating lapatinib resistance. The unexpected ability of the anti-type II diabetes drug metformin to inactivate mTOR and decrease p70S6K1 activity further reveals that this biguanide, generally considered non-toxic and remarkably inexpensive, might be considered for new combinatorial lapatinib-based protocols in HER2-overexpressing breast cancer patients. 相似文献
9.
Vicente Sabater Marco Begoña Escutia Muñoz Arturo Morera Faet Manuel Mata Roig Rafael Botella Estrada 《Journal of cutaneous pathology》2013,40(3):330-335
Spitz nevus is a benign melanocytic proliferation that shows relatively characteristic clinicopathologic features. Despite this, Spitz nevus is clinically confused with many other lesions, and histopathologically it is sometimes difficult to distinguish it from melanoma. However, Spitz nevus rarely causes differential diagnostic problems with granulomatous dermatitis. This article describes an 8‐year‐old girl who presented with a nodule on her right arm, a clinical appearance of a pyogenic granuloma. Histopathologically, there was a dermal lesion composed of aggregates of large epithelioid cells surrounded by a heavy inflammatory infiltrate, mimicking a sarcoid‐like granulomatous dermatitis. Immunohistochemistry showed epithelioid cells with strong nuclear and cytoplasmic staining with S‐100 protein, thus establishing the diagnosis of a melanocytic tumor. The heavy T‐cell lymphocytic infiltrate that accompanies the large epithelioid cells caused its granulomatous appearance. Molecular assessment showed H27H mutation in the HRAS gene. We suggest the term ‘pseudogranulomatous’ for this variant of Spitz nevus because it indicates that the lesion is not authentically granulomatous and simply mimics a granulomatous dermatitis. 相似文献