全文获取类型
收费全文 | 3090篇 |
免费 | 194篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 109篇 |
妇产科学 | 47篇 |
基础医学 | 520篇 |
口腔科学 | 40篇 |
临床医学 | 243篇 |
内科学 | 510篇 |
皮肤病学 | 163篇 |
神经病学 | 438篇 |
特种医学 | 79篇 |
外科学 | 319篇 |
综合类 | 7篇 |
一般理论 | 1篇 |
预防医学 | 309篇 |
眼科学 | 39篇 |
药学 | 204篇 |
中国医学 | 9篇 |
肿瘤学 | 216篇 |
出版年
2023年 | 22篇 |
2022年 | 39篇 |
2021年 | 67篇 |
2020年 | 56篇 |
2019年 | 76篇 |
2018年 | 76篇 |
2017年 | 61篇 |
2016年 | 93篇 |
2015年 | 70篇 |
2014年 | 103篇 |
2013年 | 120篇 |
2012年 | 238篇 |
2011年 | 235篇 |
2010年 | 119篇 |
2009年 | 115篇 |
2008年 | 196篇 |
2007年 | 184篇 |
2006年 | 198篇 |
2005年 | 227篇 |
2004年 | 183篇 |
2003年 | 161篇 |
2002年 | 167篇 |
2001年 | 27篇 |
2000年 | 14篇 |
1999年 | 45篇 |
1998年 | 41篇 |
1997年 | 38篇 |
1996年 | 38篇 |
1995年 | 37篇 |
1994年 | 24篇 |
1993年 | 27篇 |
1992年 | 11篇 |
1991年 | 7篇 |
1990年 | 10篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 5篇 |
1985年 | 7篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 14篇 |
1980年 | 6篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1967年 | 4篇 |
1928年 | 4篇 |
1927年 | 7篇 |
排序方式: 共有3291条查询结果,搜索用时 15 毫秒
1.
2.
Jürgen Schlegel Beate Ullrich Gabriele Stumm Peter Gass Ina-Maria Harwerth Nancy E. Hynes Marika Kiessling 《Acta neuropathologica》1993,86(5):473-479
The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demonstrated variable degrees of immunoreactivity in all meningiomas. The intensity of immunostaining correlated with the degree of expression as assessed by Western analysis in 28 meningiomas using polyclonal antiserum 21N. There was no correlation between the degree of expression and histological variants. Immunoreactivity of all menigiomas was distinctly less intense, however, than that of the human breast cancer cell line SK-BR-3, and slightly lower than that of brain metastases of breast and ovarian carcinomas that served as positive controls for both methods. By Southern analysis all meningiomas showed a single copy of the c-erbB-2 gene. Non-neoplastic arachnoid cap cells also exhibited c-erbB-2 expression and the degree of immunoreactivity was comparable with the majority of meningiomas. These data argue against an overexpression of c-erbB-2 in meningiomas, but rather indicate a cell-type-specific constitutive expression of the c-erbB-2 gene product in meningiomas and their putative progenitor cells. Since a subgroup of meningiomas is known to express progesterone receptors (PR), gp185 immunoreactivity was compared to the hormone receptor status using monoclonal antibody KD68. Fifty-six percent meningiomas showed PR immunoreactivity, but there was no statistically significant correlation with the degree of gp185 expression.This study was supported by a grant of the Tumorzentrum Heidelberg/Mannheim (M.K., No. 10028060) 相似文献
3.
肱骨干骨折--髓内钉与钢板固定的比较 总被引:1,自引:1,他引:0
MohidBhandari JosephR BeateP.Hanson DanC.Norvell 《中华创伤骨科杂志》2004,6(6):676-680
总体而言,这些报道提示:采用髓内钉治疗肱骨干骨折较采用钢板带来更多的并发症,尤其是采用顺行人路。同时,这些报道没有提供确切的证据证明何种方法在骨折愈合、减少感染或上肢总体功能上优于另一种。 相似文献
4.
5.
6.
7.
8.
Zipfel S Schneider A Wild B Löwe B Jünger J Haass M Sack FU Bergmann G Herzog W 《Psychosomatic medicine》2002,64(5):740-747
OBJECTIVE: This study explored the value of preoperative self-reported assessment for depression and anxiety in patients who had undergone heart transplantation (HTx). The initial sample was divided into subgroups of patients with ischemic (ICMP) and dilated cardiomyopathy (DCMP). Patient depression and anxiety scores were measured in both subgroups and their impact on pre- and postoperative mortality investigated. METHOD: An initial sample of 152 patients with either ICMP (N = 57) or DCMP (N = 95) and end-stage heart disease awaiting heart transplantation were assessed in a multidimensional longitudinal study, including psychological and somatic variables. One hundred and three patients received a HTx and were followed up for a mean of 4.4 years. Proportional hazard models were computed to test for the influence of psychosocial and somatic factors on outcome. RESULTS: Preoperative depression and state anxiety scores were significantly higher in the ICMP group. In addition to donor and recipient age, ICMP patients in the preoperative high depression group also showed a significantly higher mortality after HTx. This result remained significant even after controlling for sociodemographic and somatic variables. CONCLUSIONS: Patient self-reported depression, but not anxiety, can contribute to the identification of subgroups of patients with an unfavorable outcome after HTx. It therefore may be helpful to screen for depression, particularly in patients with an ischemic cause of their end-stage heart disease. Specific intervention programs should be further developed and evaluated. 相似文献
9.
Nadja Bogdanova Beate Lemcke Arseni Markoff Hartmut Pollmann Bernd Dworniczak Antonin Eigel Jürgen Horst 《Human mutation》2001,18(6):546-546
Haemophilia A is a X‐linked bleeding disorder, caused by deficiency in the activity of coagulation factor VIII due to mutations in the corresponding gene. The most common defect in patients is an inversion of the factor VIII gene that accounts for nearly 45% of individuals with severe hemophilia A. Point mutations and small deletions/insertions are responsible for the majority of cases with moderate to mild clinical course and for half of the severe hemophilia A occurrences. The majority of these mutations are “private”, because of the high mutation rate for this particular gene. We report on eleven pathological changes in the factor VIII sequence detected in male patients with haemophilia A or in female obligate carriers. Seven of these mutations are novel [E204N, E265X, M320T, F436C, S535C, N2129M and R2307P] and four have been previously identified [V162M, R527W, R1966X, and R2159C]. Genotype‐phenotype correlations and computer prediction analysis on the effect of missense mutations on the secondary structure of the factor VIII protein are performed and the relationships evaluated. © 2001 Wiley‐Liss, Inc. 相似文献
10.
Tadech Boonpiyathad Willem van de Veen Oliver Wirz Milena Sokolowska Beate Rückert Ge Tan Atik Sangasapaviliya Panitan Pradubpongsa Rattanaporn Fuengthong Pattarawat Thantiworasit Sunee Sirivichayakul Kiat Ruxrungtham Cezmi A. Akdis Mübeccel Akdis 《The Journal of allergy and clinical immunology》2019,143(3):1077-1086.e10