表小檗碱对α受体的作用

表小檗碱(epiberberine,EB)是从湖北产黄连(Coptis chinensis Franch)中提取的一种生物碱,属苯喹嗪类原小檗碱,对其药理作用的研究资料甚少,未见其对α肾上腺素体作用的报道。资料表明,许多原小檗碱类化合物有α受体阻滞作用,为从该类化合物中选择     

Pain and faulty breathing: a pilot study

The purpose of this pilot study was to observe both relaxed and deep breathing patterns in a convenience sample to determine the incidence of normal versus faulty patterns of respiration. These observations were then combined with respondent answers to a survey on pain history to determine if there is any correlation between faulty breathing and musculo-skeletal pain patterns. If such a correlation can be made, then we propose that clinicians working with chronic pain patients may have improved outcomes if they address and correct faulty breathing patterns. Based on this study, it is suggested to include the evaluation and treatment of faulty respiration in the rehabilitation of chronic musculo-skeletal conditions, most notably cervical pain.     

Schock

Shock is defined as a disproportion between oxygen supply and consumption based on a deficient perfusion of vital organs. Reduction of circulating blood volume (hypovolemic shock), cardiac failure with low output (cardiac shock) or the failure of peripheral vascular resistance (distributive shock) can result in shock. Preclinically the diagnosis of shock is determined by exploration, physical examination and – some – monitoring only. Therapy is directed towards the underlying cause whilst recovery and maintenance of adequate perfusion of vitals and tissue are of primary importance. This strategy includes the application of oxygen, fluids and catecholamines. Moreover, the choice of the hospital for further therapy is crucial in case of emergency.     

Structure-activity relations of antineoplastic platinum II and platinum IV coordination compounds

Five diammine-Pt(II) or Pt(IV) coordination compounds, namely cis-diammine-dichloro-platinum (II) "cis-DDP", transdihydroxy-cis-diammine-dichloro-platinum (IV) "trans-ODDP", and derived substitution products of lactic acid (racemates or L-forms) with diminished toxicity in comparison to cis-DDP have been tested against mouse leukemia P388, and partly on melanoma B16 for antineoplastic activity. The results have been compared with those obtained with the clinical approved cis-DDP. They were not in every way equal to the antitumor efficiency of cis-DDP. Improved physicochemical properties as well as favorable differences of side effects in contrast to cis-DDP, could be decisive for the potential value of these substances.