全文获取类型
收费全文 | 163篇 |
免费 | 84篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 8篇 |
妇产科学 | 1篇 |
口腔科学 | 2篇 |
临床医学 | 119篇 |
内科学 | 69篇 |
神经病学 | 3篇 |
外科学 | 7篇 |
预防医学 | 25篇 |
药学 | 9篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 7篇 |
2022年 | 2篇 |
2021年 | 7篇 |
2020年 | 17篇 |
2018年 | 26篇 |
2017年 | 22篇 |
2016年 | 24篇 |
2015年 | 20篇 |
2014年 | 16篇 |
2013年 | 19篇 |
2012年 | 10篇 |
2011年 | 7篇 |
2010年 | 11篇 |
2009年 | 19篇 |
2008年 | 5篇 |
2007年 | 1篇 |
2006年 | 1篇 |
2005年 | 8篇 |
2004年 | 4篇 |
2003年 | 3篇 |
2002年 | 1篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1992年 | 1篇 |
排序方式: 共有247条查询结果,搜索用时 0 毫秒
1.
Shahar Shmuel PhD Virginia Pate MS Marc J. Pepin PharmD BCPS BCGP Janine C. Bailey PharmD BCPS Yvonne M. Golightly PT MS PhD Laura C. Hanson MD MPH Til Stürmer MD MPH PhD Rebecca B. Naumann PhD Danijela Gnjidic PhD Jennifer L. Lund PhD 《Journal of the American Geriatrics Society》2021,69(11):3212-3224
2.
Implementation and Preliminary Clinical Outcomes of a Pharmacist‐managed Venous Thromboembolism Clinic for Patients Treated With Rivaroxaban Post Emergency Department Discharge 下载免费PDF全文
Baely M. DiRenzo PharmD BCPS Daren M. Beam MD MS Jeffrey A. Kline MD Karishma S. Deodhar PharmD BCPS Zachary A. Weber PharmD BCPS BCACP CDE Christie M. Davis PharmD BCPS Todd A. Walroth PharmD BCPS BCCCP 《Academic emergency medicine》2018,25(6):634-640
Objective
The objective was to describe the implementation, work flow, and differences in outcomes between a pharmacist‐managed clinic for the outpatient treatment of venous thromboembolism (VTE) using a non‐vitamin K oral anticoagulant versus care by a primary care provider (PCP).Methods
Patients in the studied health system that are diagnosed with low‐risk VTE in the emergency department are often discharged without hospital admission. These patients are treated with a non‐vitamin K oral anticoagulant and follow‐up either in a pharmacist‐managed VTE clinic or with their PCP. Pharmacists in the VTE clinic work independently under a collaborative practice agreement (CPA). An evaluation of 34 patients, 17 in each treatment arm, was conducted to compare the differences in treatment‐related outcomes of rivaroxaban when managed by a pharmacist versus a PCP.Results
The primary endpoint was a 6‐month composite of anticoagulation treatment‐related complications that included a diagnosis of major bleeding, recurrent thromboembolism, or fatality due to either major bleeding or recurrent thromboembolism. Secondary endpoints included number of hospitalizations, adverse events, and medication adherence. There was no difference in the primary endpoint between groups with one occurrence of the composite endpoint in each treatment arm (p = 1.000), both of which were recurrent thromboembolic events. Medication adherence assessment was formally performed in eight patients in the pharmacist group versus no patients in the control group. No differences were seen among other secondary endpoints.Conclusions
The pharmacist‐managed clinic is a novel expansion of clinical pharmacy services that treats patients with low‐risk VTEs with rivaroxaban in the outpatient setting. The evaluation of outcomes provides support that pharmacist‐managed care utilizing standardized protocols under a CPA may be as safe as care by a PCP.3.
4.
Leung AA Keohane C Amato M Simon SR Coffey M Kaufman N Cadet B Schiff G Zimlichman E Seger DL Yoon C Song P Bates DW 《Journal of general internal medicine》2012,27(7):801-807
BACKGROUND
It is uncertain if computerized physician order entry (CPOE) systems are effective at reducing adverse drug event (ADE) rates in community hospitals, where mainly vendor-developed applications are used.OBJECTIVE
To evaluate the impact of vendor CPOE systems on the frequency of ADEs.DESIGN AND PATIENTS
Prospective before-and-after study conducted from January 2005 to September 2010 at five Massachusetts community hospitals. Participants were adults admitted during the study period. A total of 2,000 charts were reviewed for orders, medication lists, laboratory reports, admission histories, notes, discharge summaries, and flow sheets.MAIN MEASURES
The primary outcome measure was the rate of preventable ADEs. Rates of potential ADEs and overall ADEs were secondary outcomes.KEY RESULTS
The rate of preventable ADEs decreased following implementation (10.6/100 vs. 7.0/100 admissions; p?=?0.007) with a similar effect observed at each site. However, the associated decrease in preventable ADEs was balanced against an increase in potential ADEs (44.4/100 vs. 57.5/100 admissions; p?0.001). We observed a reduction of 34.0% for preventable ADEs, but an increase of 29.5% in potential ADEs following implementation. The overall rate of ADEs increased (14.6/100 vs. 18.7/100 admissions; p?=?0.03), which was driven by non-preventable events (4.0/100 vs. 11.7/100 admissions; p?0.001).CONCLUSIONS
Adoption of vendor CPOE systems was associated with a decrease in the preventable ADE rate by a third, although the rates of potential ADEs and overall ADEs increased. Our findings support the use of vendor CPOE systems as a means to reduce drug-related injury and harm. The potential ADE rate could be reduced by making refinements to the vendor applications and their associated decision support. 相似文献5.
Nayahmka McGriff-Lee PharmD Sophia N. Kalantaridou MD PhD Frank Pucino PharmD BCPS FASHP FDPGEC Karim Anton Calis PharmD MPH BCPS BCNPS FASHP FCCP 《Clinical reviews in bone and mineral metabolism》2005,3(1):51-66
Although the beneficial effects of estrogen on bone have been proven in multiple well-designed clinical trials, with respect
to testosterone and androgens, the data are less definitive. Testosterone appears to have a role in the development and maintenance
of bone mass; however, the mechanism by which androgens exert their effects on bone is still not clearly understood. Despite
the increasing use of testosterone supplementation in men and women for the prevention and treatment of osteoporosis, in sufficient
evidence exists to support the widespread use of these agents for this indication at this time. The data supporting the beneficial
effects of testosterone on bone mineral density are more convincing in hypogonadal men than in men with normal testosterone
levels, or in women. The transdermal route of administration is often preferred for testosterone therapy because it avoids
the first-pass metabolism associated with oral formulations and the pain experienced with intramuscular injections. Other
androgens, including an abolic steroids and dihydroepiandrosterone, have also been used. In addition to monitoring for therapeutic
response on initiation of androgen therapy, assessment for potential adverse events should be implemented. This should include
assessment for adverse effects on the liver and alterations in the lipid profile in both men and women. Men should also be
monitored for prostate growth, gynecomastia, priapism, decreased libido, and erythrocytosis, whereas women should be monitored
for virilizing effects. Ongoing research into the pathophysiology and clinical effects of testosterone on bone will provide
more insights regarding the utility of androgens in these populations. 相似文献
6.
7.
Andrew J. Franck PharmD BCPS BCNSP 《JPEN. Journal of parenteral and enteral nutrition》2014,38(5):637-639
Parenteral nutrition product shortages are common and place vulnerable patients at risk for nutrient deficiencies. This case report describes a parenteral nutrition–dependent patient who was found to have zinc deficiency during a parenteral nutrition product shortage. The management of the patient's zinc deficiency is described. 相似文献
8.
9.
Kara J. Walters PharmD Anna Meador PharmD BCACP John A. Galdo PharmD BCPS CGP Katharine Ciarrocca DMD MSEd 《Special care in dentistry》2017,37(2):62-70
Coagulation disorders account for a high incidence of death in the U.S. due to stroke, myocardial infarction, and venous thromboembolism. In the past few years, numerous agents have been brought to market for the treatment of thromboembolism or prevention of thromboembolism. Similar to warfarin, these agents can cause bleeding disorders, which may exacerbate dental care treatment plans. This literature review examines the newer agents for the treatment of thromboembolism disorders, common side effects and drug interactions, the specific medical conditions each agent treats, and the dental perspective on how to medically management patients prescribed these medications. 相似文献
10.