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Charlene Compher PhD RD CNSC FASPEN Ajay K. Jain MD Peter F. Nichol MD PhD Allison Blackmer PharmD BCPS BCPPS Carrie Earthman PhD RD David C. Evans MD FACS Mary S. McCarthy PhD RN CNSC FAAN Beth Taylor DCN RDN‐AP CNSC FCCM Nilesh Mehta MD 《JPEN. Journal of parenteral and enteral nutrition》2018,42(5):838-844
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Higher Doses of Fish Oil–Based Lipid Emulsions Used to Treat Inadequate Weight Gain and Rising Triene:Tetraene Ratio in a Severely Malnourished Infant With Intestinal Failure–Associated Liver Disease 下载免费PDF全文
Mary Riedy PharmD BCPPS Brittany DePaula RD LDN Mark Puder MD PhD Kathleen M. Gura PharmD Kevin A. Sztam MD MPH 《JPEN. Journal of parenteral and enteral nutrition》2017,41(4):667-671
Fish oil–based lipid emulsions (FOLEs) have been used to treat cholestasis in children with intestinal failure–associated liver disease (IFALD). When FOLEs are dosed at 1 g/kg/d, essential fatty acid (EFA) deficiency typically does not occur. We describe the clinical course of a severely malnourished parenteral nutrition–dependent infant with IFALD. Baseline EFA panels were normal upon starting FOLE at 1 g/kg/d. Despite biochemical improvement in IFALD, weight velocity was below target and biochemical EFA status worsened, even after correction for other factors affecting weight. The FOLE dose was increased to 1.5 g/kg/d, resulting in improvement of weight velocity and EFA status. This suggests that in severely malnourished infants being treated for IFALD, higher doses of FOLE may be required for adequate growth and to prevent EFA deficiency. 相似文献
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