全文获取类型
收费全文 | 1036篇 |
免费 | 44篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 51篇 |
妇产科学 | 21篇 |
基础医学 | 73篇 |
口腔科学 | 37篇 |
临床医学 | 100篇 |
内科学 | 170篇 |
皮肤病学 | 10篇 |
神经病学 | 39篇 |
特种医学 | 119篇 |
外科学 | 323篇 |
综合类 | 10篇 |
预防医学 | 63篇 |
眼科学 | 3篇 |
药学 | 60篇 |
1篇 | |
肿瘤学 | 46篇 |
出版年
2023年 | 5篇 |
2022年 | 8篇 |
2021年 | 6篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 10篇 |
2016年 | 12篇 |
2015年 | 16篇 |
2014年 | 20篇 |
2013年 | 31篇 |
2012年 | 10篇 |
2011年 | 12篇 |
2010年 | 21篇 |
2009年 | 30篇 |
2008年 | 28篇 |
2007年 | 55篇 |
2006年 | 33篇 |
2005年 | 28篇 |
2004年 | 20篇 |
2003年 | 29篇 |
2002年 | 31篇 |
2001年 | 21篇 |
2000年 | 43篇 |
1999年 | 28篇 |
1998年 | 45篇 |
1997年 | 58篇 |
1996年 | 58篇 |
1995年 | 53篇 |
1994年 | 39篇 |
1993年 | 30篇 |
1992年 | 7篇 |
1991年 | 25篇 |
1990年 | 18篇 |
1989年 | 22篇 |
1988年 | 37篇 |
1987年 | 30篇 |
1986年 | 29篇 |
1985年 | 35篇 |
1984年 | 14篇 |
1983年 | 12篇 |
1982年 | 12篇 |
1981年 | 12篇 |
1980年 | 16篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 11篇 |
1975年 | 4篇 |
1968年 | 6篇 |
1967年 | 5篇 |
1966年 | 4篇 |
排序方式: 共有1128条查询结果,搜索用时 0 毫秒
1.
2.
3.
Carel Bron Michel Wensing Jo LM Franssen Rob AB Oostendorp 《BMC musculoskeletal disorders》2007,8(1):107
Background
Shoulder disorders are a common health problem in western societies. Several treatment protocols have been developed for the clinical management of persons with shoulder pain. However available evidence does not support any protocol as being superior over others. Systematic reviews provide some evidence that certain physical therapy interventions (i.e. supervised exercises and mobilisation) are effective in particular shoulder disorders (i.e. rotator cuff disorders, mixed shoulder disorders and adhesive capsulitis), but there is an ongoing need for high quality trials of physical therapy interventions. Usually, physical therapy consists of active exercises intended to strengthen the shoulder muscles as stabilizers of the glenohumeral joint or perform mobilisations to improve restricted mobility of the glenohumeral or adjacent joints (shoulder girdle). It is generally accepted that a-traumatic shoulder problems are the result of impingement of the subacromial structures, such as the bursa or rotator cuff tendons. Myofascial trigger points (MTrPs) in shoulder muscles may also lead to a complex of symptoms that are often seen in patients diagnosed with subacromial impingement or rotator cuff tendinopathy. Little is known about the treatment of MTrPs in patients with shoulder disorders. 相似文献4.
5.
Dominant A1: angiographic and clinical correlations with anterior communicating artery aneurysms. 总被引:1,自引:0,他引:1
It has been observed but never proven that anomalies of the anterior communicating artery complex are associated with anterior communicating artery aneurysms (ACAA). Therefore, in an effort to understand the significance of haemodynamic factors in the genesis, as well as the clinical course of ACAA, we evaluated the correlation between certain angiographic patterns of flow in the anterior circulation and the clinical findings of 51 patients with ACAA compared with 50 matched controls. Four significant associations which have never been validated were identified: 1) a dominant A1 (filling both A2's) was found in 57% of ACAA patients versus 14% of controls (p less than 0.001). 2) Unilateral hypoplasia of the opposite A1 was present in 24% of ACAA patients versus 6% of controls (p = 0.01). 3) Exclusive filling of the ACAA from one A1 occurred in 78%. 4) No statistically significant relationship was found between the anatomic flow patterns studied and the patients clinical presentation including age, sex, or grade. We conclude that anterior communicating artery aneurysms are significantly related in a majority of patients with the presence of a dominant A1, probably as the result of enhanced haemodynamic stress caused by this anatomic abnormality in the circulation. However, this association is not constant, and a dominant pattern of flow did not correlate with the clinical course. This is probably a reflection of the differences between factors initiating aneurysm formation and those influencing its growth, as well as of the relative limitations of angiography when pathophysiological extrapolations are attempted. 相似文献
6.
Brain tissue oxygenation in patients with cerebral occlusive disease and arteriovenous malformations
Hoffman W. E.; Charbel F. T.; Edelman G.; Ausman J. I. 《British journal of anaesthesia》1997,78(2):169-171
It is not clear if ventilation with oxygen increases brain tissue oxygen
pressure (PO2) during ischaemia. We have measured brain tissue PO2, carbon
dioxide pressure (PCO2) and pH during baseline anaesthesia and oxygen
ventilation in non-ischaemic control patients (n = 9), patients with
cerebral occlusive disease (n = 11) and patients with arteriovenous
malformations (AVM, n = 12). The same anaesthetic treatment was given to
all groups and anaesthesia was constant during the study. Arterial
pressure, brain temperature and arterial blood-gas tensions were similar
between groups. Under baseline conditions, brain tissue PO2 was mean 4.2
(SD 1.4) kPa in the controls and was 70% lower in patients with ischaemia
and AVM. Patients with occlusive disease also had elevated tissue PCO2 and
acidosis. During oxygen ventilation, PO2 increased to 7.5 (2.9) kPa in
controls and this was 50% greater than the increase in the ischaemia and
AVM patients. The results showed that baseline tissue oxygenation and
increases in PO2 during hyperoxia were attenuated in patients with
ischaemia or AVM.
相似文献
7.
8.
M. Dujovny K. V. Slavin M. S. Luer G. Hernandez-Avila J. I. Ausman 《Acta neurochirurgica》1995,133(1-2):83-86
Summary Different methods have been used in the evaluation and monitoring of the cerebral oxygen supply during neuro-interventional therapies. Attenuation of near-infrared light by the chromophores oxyhemoglobin and deoxyhemoglobin have shown to be useful in the study of the cellular oxygen metabolism and oxygen delivery to the brain. Transcranial cerebral oximetry (TCCO) has the advantage of providing real-time information regarding regional brain oxygen saturation (rSO2) by using wavelengths in the near-infrared range.We present a patient with a carotid cavernous fistula who underwent balloon occulusion and concurrent continuous TCCO monitoring. TCCO was found to be a useful tool providing immediate rSO2 values during the angiographic and interventional procedures. Initial balloon occlusion of a carotid cavernous fistula resulted in partial occlusion of the internal carotid artery lumen causing an immediate decrease in rSO2 which correlated with angiographic findings. Subsequent reocclusion of the fistula produced a slower and smaller degree of decrease in rSO2 with clinical improvement in the patient. Changes in rSO2 were detected before any adverse clinical event was observed. TCCO was reliable, safe, sensitive, and provided a real-time assessment tool for the monitoring of brain oxygen supply in a patient undergoing a neuroendovascular procedure. 相似文献
9.
10.
Andres A; Morales JM; Praga M; Campo C; Lahera V; Garcia-Robles R; Rodicio JL; Ruilope LM 《Nephrology, dialysis, transplantation》1997,12(7):1437-1440
BACKGROUND: Cyclosporin has been shown to facilitate renal vasoconstriction
and to have an antinatriuretic effect. The existence of an interference of
cyclosporin with the vasodilating properties of endothelium mediated by
nitric oxide production could mediate these effects. On the other hand, the
infusion of the nitric oxide precursor L-arginine has been shown to induce
renal vasodilatation and to facilitate natriuresis in normal volunteers. We
have investigated the renal effects of the administration of an infusion of
L-arginine in renal transplant patients chronically treated with
cyclosporin. To facilitate the analysis of the data the effects of the
administration of a similar dose of cyclosporin on renal function during
the infusion of a vehicle were also investigated during the administration
of a vehicle of L-arginine. DESIGN: Ten male renal transplant patients,
chronically treated with cyclosporin and with a stable renal function were
studied during 2 consecutive days after the administration of the usual
morning dose of cyclosporin. The first day they received an intravenous
infusion of vehicle and the second the infusion of graded doses of
L-arginine (50, 100, 150 mg/kg/h) during 3 consecutive h. RESULTS: The
first day, after cyclosporin administration a significant fall (P <
0.01) was observed in natriuresis and kaliuresis in the absence of changes
in renal plasma flow and glomerular filtration rate. After the
administration of L-arginine significant (P < 0.01) increases of renal
plasma flow, glomerular filtration rate, and natriuresis were seen. The
increase in blood levels of cyclosporin after its administration did not
differ between days 1 and 2. CONCLUSION: These results indicate that
L-arginine facilitates renal vasodilatation and natriuresis in renal
transplant patients. Furthermore, the observed increase in sodium excretion
could indicate that L-arginine counteracts the antinatriuretic effect of
cyclosporin.
相似文献