全文获取类型
收费全文 | 808篇 |
免费 | 52篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 25篇 |
妇产科学 | 120篇 |
基础医学 | 57篇 |
口腔科学 | 12篇 |
临床医学 | 72篇 |
内科学 | 199篇 |
皮肤病学 | 11篇 |
神经病学 | 34篇 |
特种医学 | 5篇 |
外科学 | 162篇 |
综合类 | 12篇 |
预防医学 | 49篇 |
眼科学 | 12篇 |
药学 | 32篇 |
中国医学 | 2篇 |
肿瘤学 | 57篇 |
出版年
2023年 | 4篇 |
2022年 | 14篇 |
2021年 | 34篇 |
2020年 | 17篇 |
2019年 | 21篇 |
2018年 | 43篇 |
2017年 | 20篇 |
2016年 | 27篇 |
2015年 | 19篇 |
2014年 | 20篇 |
2013年 | 30篇 |
2012年 | 73篇 |
2011年 | 73篇 |
2010年 | 49篇 |
2009年 | 35篇 |
2008年 | 58篇 |
2007年 | 57篇 |
2006年 | 58篇 |
2005年 | 40篇 |
2004年 | 36篇 |
2003年 | 31篇 |
2002年 | 27篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 10篇 |
1998年 | 2篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1932年 | 1篇 |
排序方式: 共有864条查询结果,搜索用时 0 毫秒
1.
Aris A Bonnin JO Solé JO Padró JM Bartomeus F Molet J Oliver B Caralps JM 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》1986,13(3):313-319
We report two patients with coarctation of the aorta who were admitted to the hospital with ruptured cerebral artery aneurysms. In both patients, we surgically treated the coarctation and later repaired the intracranial lesion. One patient, a 34-year-old woman, is alive and well after 3 years; whereas, the other, a 19-year-old man, did not survive. We discuss the sequence for surgery, which continues to be subjected to debate. 相似文献
2.
Mandruzzato G Antsaklis A Botet F Chervenak FA Figueras F Grunebaum A Puerto B Skupski D Stanojevic M;WAPM 《Journal of perinatal medicine》2008,36(4):277-281
Perinatal mortality and morbidity is markedly increased in intrauterine growth restricted (IUGR) fetuses. Prenatal identification of IUGR is the first step in clinical management. For that purpose a uniform definition and criteria are required. The etiology of IUGR is multifactorial and whenever possible it should be assessed. When the cause is of placental origin, it is possible to identify the affected fetuses. The major complication is chronic fetal hypoxemia. By monitoring the changes of fetal vital functions it is thus possible to improve both management and outcome. The timing of delivery is crucial but the optimal management scheme has not yet been identified. When IUGR is identified at very early gestational ages, serial assessments of the risk of continuing the in utero fetal life under adverse conditions versus the risks of the prematurity should be performed. Delivery of IUGR fetuses should take place in centers where appropriate neonatal assistance can be provided. Careful monitoring of the IUGR fetus during labor is crucial as the IUGR fetus can quickly decompensate once uterine contractions have started. 相似文献
3.
4.
Clinical and urodynamic parameters associated with history of urinary tract infections in women 总被引:1,自引:0,他引:1
Athanasiou S Anstaklis A Betsi GI Sotiropoulou M Falagas ME 《Acta obstetricia et gynecologica Scandinavica》2007,86(9):1130-1135
OBJECTIVES: To evaluate the association of various clinical and urodynamic variables with history of urinary tract infections (UTIs) in women. METHODS: A prospective study of 2,081 women referred to a urogynecologic clinic between June 2000 and November 2005 for investigation of lower urinary tract symptoms. RESULTS: Some 144 women reported history of UTI(s) within the last year from the visit to the clinic, and 91 had recurrent episodes (> or =3 per year). The multivariable analysis showed that urge incontinence (odds ratio (OR) = 2.23, 95% confidence interval (CI): 1.46-3.42), suprapubic pain (OR = 4.12, 95% CI: 2.21-7.67), and low maximum flow rate during voiding cystometry (OR = 0.96, 95% CI: 0.94-0.98) associated with UTIs. CONCLUSIONS: Our results suggest that urodynamic testing does not help in identifying specific urogynecologic mechanisms that could improve medical and/or surgical management or prevent recurrent UTI. 相似文献
5.
PURPOSE OF REVIEW: To review publications, published during the past year, that have examined uterine artery Doppler findings in women with adverse pregnancy outcome. RECENT FINDINGS: Almost two-thirds of stillbirths that occur in the early preterm period (up to 32 weeks) can be predicted by uterine artery Doppler at 23 weeks. First trimester screening studies have shown that an abnormal result increases the risk of subsequent fetal growth restriction, and such women are at particularly high risk when indices remain abnormal in the second trimester. Studies combining uterine artery Doppler with maternal serum markers have demonstrated that measurement of first-trimester maternal serum pregnancy-associated plasma protein A and free beta human chorionic gonadotrophin improve sensitivities of second-trimester Doppler. As these are frequently measured in Down syndrome screening and they lend themselves in screening for pre-eclampsia. Women with abnormal first and second-trimester serum markers constitute a high-risk group. Maternal serum placental protein 13 remains a promising method for early screening, although a recent study suggests lower sensitivities than initially reported. SUMMARY: Uterine artery Doppler screening identifies women at high risk for developing adverse pregnancy outcomes. Detection rates may be increased and false positive rates reduced by combination with maternal characteristics or serum markers. 相似文献
6.
Yoshihiro Yoshikawa Aruna Kode Lili Xu Ioanna Mosialou Barbara C Silva Mathieu Ferron Thomas L Clemens Aris N Economides Stavroula Kousteni 《Journal of bone and mineral research》2011,26(9):2012-2025
The skeleton has been shown recently to regulate glucose metabolism through an osteoblast‐specific hormone, osteocalcin, which favors β‐cell proliferation, insulin secretion, insulin sensitivity, and energy expenditure. An implication of this finding is that a decrease in osteoblast numbers would compromise glucose metabolism in an osteocalcin‐dependent manner. To test this hypothesis, osteoblasts were inducibly ablated by cross‐breeding transgenic mice expressing a tamoxifen‐regulated Cre under the control of the osteocalcin promoter with mice in which an inactive form of the diphtheria toxin A chain was introduced into a ubiquitously expressed locus. Ablation of osteoblasts in adult mice profoundly affected glucose metabolism. In a manner similar to what is seen in the case of osteocalcin deficiency, a partial ablation of this cell population resulted in hypoinsulinemia, hyperglycemia, glucose intolerance, and decreased insulin sensitivity. However, and unlike what is seen in osteocalcin‐deficient mice, osteoblast ablation also decreased gonadal fat and increased energy expenditure and the expression of resistin, an adipokine proposed to mediate insulin resistance. While administration of osteocalcin reversed (fully) the glucose intolerance and reinstated normal blood glucose and insulin levels, it only partially restored insulin sensitivity and did not affect the improved gonadal fat weight and energy expenditure in osteoblast‐depleted mice. These observations not only strengthen the notion that osteoblasts are necessary for glucose homeostasis and energy expenditure but also suggest that in addition to osteocalcin, other osteoblast‐derived hormones may contribute to the emerging function of the skeleton as a regulator of energy metabolism. © 2011 American Society for Bone and Mineral Research 相似文献
7.
Marcus P Kennedy Raymond D Coakley Scott H Donaldson Robert M Aris Kathy Hohneker Joel P Wedd Michael R Knowles Peter H Gilligan James R Yankaskas 《Journal of cystic fibrosis》2007,6(4):267-273
BACKGROUND: The impact of infection with Burkholderia gladioli in cystic fibrosis, other chronic airway diseases and immunosuppressed patients is unknown. METHODS: A six-year retrospective review of all patients with B. gladioli infection was performed in a tertiary referral center with cystic fibrosis and lung transplantation programs. In addition, a targeted survey of all 251 lung transplant recipients was performed. Available B. gladioli isolates were analyzed via pulsed field gel electrophoresis. RESULTS: Thirty-five patients were culture positive for B. gladioli, including 33 CF patients. No bacteremia was identified. Isolates were available in 18 patients and all were genetically distinct. Two-thirds of these isolates were susceptible to usual anti-pseudomonal antibiotics. After acquisition, only 40% of CF patients were chronically infected (> or =2 positive cultures separated by at least 6 months). Chronic infection was associated with resistance to > or =2 antibiotic groups on initial culture and failure of eradication after antibiotic therapy. The impact of acquisition of B. gladioli infection in chronic infection was variable. Three CF patients with chronic infection underwent lung transplantation. One post-transplant patient developed a B. gladioli mediastinal abscess, which was treated successfully. CONCLUSIONS: The majority of patients' culture positive for B. gladioli at our center have CF. B. gladioli infection is often transient and is compatible with satisfactory post-lung transplantation outcomes. 相似文献
8.
Manousakas T Kyriakou G Serafetinides E Giannopoulou M Kyroudi A Giannopoulos A 《Urology》2002,59(4):602
Congenital seminal vesicle cysts associated with renal agenesis are uncommon, but are currently detected more frequently with the use of sectional imaging procedures. Approximately 200 cases have been reported. The unique feature of our case is the combination of this disorder with an ipsilateral undescended testis. Our patient underwent partial vesiculectomy, in which the cyst was removed and the seminal vesicle remnant with its vas deferens was preserved. A review of the infertile cases and the impact of surgical treatment on fertility are discussed. Features that render partial vesiculectomy applicable and the potential effect of this procedure on fertility are highlighted. 相似文献
9.
Background Aesthetic surgery of the thoracoabdominal region is one of the most frequently performed surgical procedures in plastic surgery.The
combination of circumferential liposuction, autologous fat grafting of the buttocks and/or lower limbs, and the modified transverse
abdominoplasty as an adjuvant procedure all done in a single surgical procedure is not very common. The authors present a
prospective study of the surgical technique of composite body contouring, emphasizing the low rate of complications and the
high overall patient satisfaction.
Methods A total of 64 consecutive female patients were operated on between January 2004 and January 2007. All the patients who were
included in the study were candidates for a classical abdominoplasty. Posterior and lateral syringe-assisted liposuction combined
with fat insertion into the buttocks and/or lower limbs was performed. Autologous fat grafting was done in the gluteal area
for buttocks enhancement and in the lower limbs to correct contour deformities. Anterolateral liposuction with modified transverse
abdominoplasty was done as an adjuvant procedure. Overall satisfaction with body appearance after composite body contouring
was rated on a scale of 1–5.
Results From 1,500 to 4,600 ml of fat was obtained with liposuction (mean = 2,478 ml). Forty-five patients had fat grafting only to
the buttocks area. Six patients had fat insertion into the lower limbs and 13 had fat injection into the buttocks and lower
limbs. The amount of fat transplanted to the buttocks varied from 165 to 625 ml (mean = 346 ml) and to the lower limbs it
varied from 75 to 270 ml (mean = 195 ml). Three patients (5%) suffered from early complications, including infection (3%)
and hematoma formation (2%). Nine patients (14%) had late complications, including hypertophic scars (7.5%), dog ears (4.5%),
and localized fat excess (2%). Nine patients (14%) underwent revision surgery. Sixty-three percent reported that their appearance
after composite body contouring was “very good” (42%) or “excellent” (21%) and 27% responded that their appearance was “good.”
Only 10% thought their appearance was less than good, (7% “fair” and 3% “poor”).The average follow-up time has been 3.2 years
(range = 2–5 years).
Conclusion Composite body contouring combines circumferential liposuction, fat grafting of the buttocks and lower limbs, and modified
transverse abdominoplasty to accomplish very good aesthetic results in a single surgical procedure with a low rate of complications
and high patient satisfaction. 相似文献
10.
We compared the efficacy of IV fentanyl with IV lidocaine as pretreatment for the prevention of withdrawal response after rocuronium injection. For this prospective, randomized, placebo-controlled, double-blind study we recruited 90 patients aged between 18 and 65 yr, ASA physical status I or II, who had undergone elective surgery requiring general anesthesia and positive pressure ventilation. Patients were randomly allocated to 1 of 3 groups: group F received 2 mL IV fentanyl 50 microg/mL (100 microg), group L received 2 mL of preservative-free lidocaine 2% (40 mg), and group P (placebo) received 2 mL of normal saline. The incidence of withdrawal response after rocuronium was 57%, 30%, and 7% in the placebo, lidocaine, and fentanyl groups, respectively. We found a significant reduction in incidence of withdrawal response in both the fentanyl and lidocaine groups when compared with the placebo group (P < 0.05), with the fentanyl group being most effective (P < 0.05). In conclusion, both fentanyl and lidocaine are effective clinical treatments to alleviate the withdrawal response associated with rocuronium injection, with fentanyl being more effective. 相似文献