全文获取类型
收费全文 | 1455篇 |
免费 | 78篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 86篇 |
妇产科学 | 37篇 |
基础医学 | 149篇 |
口腔科学 | 18篇 |
临床医学 | 146篇 |
内科学 | 376篇 |
皮肤病学 | 15篇 |
神经病学 | 76篇 |
特种医学 | 191篇 |
外科学 | 145篇 |
综合类 | 39篇 |
预防医学 | 54篇 |
眼科学 | 14篇 |
药学 | 95篇 |
中国医学 | 6篇 |
肿瘤学 | 92篇 |
出版年
2022年 | 17篇 |
2021年 | 26篇 |
2020年 | 15篇 |
2019年 | 30篇 |
2018年 | 43篇 |
2017年 | 25篇 |
2016年 | 36篇 |
2015年 | 25篇 |
2014年 | 53篇 |
2013年 | 60篇 |
2012年 | 64篇 |
2011年 | 70篇 |
2010年 | 54篇 |
2009年 | 51篇 |
2008年 | 53篇 |
2007年 | 62篇 |
2006年 | 42篇 |
2005年 | 48篇 |
2004年 | 30篇 |
2003年 | 36篇 |
2002年 | 37篇 |
2001年 | 23篇 |
2000年 | 30篇 |
1999年 | 44篇 |
1998年 | 28篇 |
1997年 | 42篇 |
1996年 | 36篇 |
1995年 | 34篇 |
1994年 | 27篇 |
1993年 | 21篇 |
1992年 | 25篇 |
1991年 | 35篇 |
1990年 | 26篇 |
1989年 | 39篇 |
1988年 | 30篇 |
1987年 | 27篇 |
1986年 | 25篇 |
1985年 | 25篇 |
1984年 | 16篇 |
1983年 | 22篇 |
1982年 | 13篇 |
1981年 | 11篇 |
1980年 | 7篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1975年 | 12篇 |
1972年 | 6篇 |
1967年 | 6篇 |
1966年 | 6篇 |
排序方式: 共有1557条查询结果,搜索用时 15 毫秒
1.
2.
3.
MEMRI and tumors: a method for the evaluation of the contribution of Mn(II) ions in the extracellular compartment
下载免费PDF全文
![点击此处可从《NMR in biomedicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eliana Gianolio Francesca Arena Enza Di Gregorio Roberto Pagliarin Martina Delbianco Gabriella Baio Silvio Aime 《NMR in biomedicine》2015,28(9):1104-1110
The purpose of the work was to set‐up a simple method to evaluate the contribution of Mn2+ ions in the intra‐ and extracellular tumor compartments in a MEMRI experiment. This task has been tackled by “silencing” the relaxation enhancement arising from Mn2+ ions in the extracellular space. In vitro relaxometric measurements allowed assessment of the sequestering activity of DO2A (1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid) towards Mn2+ ions, as the addition of Ca‐DO2A to a solution of MnCl2 causes a drop of relaxivity upon the formation of the highly stable and low‐relaxivity Mn‐DO2A. It has been proved that the sequestering ability of DO2A towards Mn2+ ions is also fully effective in the presence of serum albumin. Moreover, it has been shown that Mn‐DO2A does not enter cell membranes, nor does the presence of Ca‐DO2A in the extracellular space prompt migration of Mn ions from the intracellular compartment. On this basis the in vivo, instantaneous, drop in SE% (percent signal enhancement) in T1‐weighted images is taken as evidence of the sequestration of extracellular Mn2+ ions upon addition of Ca‐DO2A. By applying the method to B16F10 tumor bearing mice, T1 decrease is readily detected in the tumor region, whereas a negligible change in SE% is observed in kidneys, liver and muscle. The relaxometric MRI results have been validated by ICP‐MS measurements. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
4.
5.
6.
杨兴旺 《眼外伤职业眼病杂志》1994,16(3):202-204
采用综合治疗,抗炎,散瞳,局部治疗与全身应用免疫抑制疗法,治疗319例352眼外伤获得了满意的疗效,眼球挫伤104例,眼球穿孔伤93例,化学烧伤71例,眼炸伤46例。眼热烧伤5例,治疗包括及时清创胶粘或缝合,清除前房出血合理用皮质类固醇和免疫抑制剂等。眼球挫伤治愈率97.12%,穿透伤93.18%,热烧伤66.67%。319例眼外伤治愈率94.67%好转5.33%,并对各种治疗方法进行了讨论。 相似文献
7.
8.
Retrorenal colon: implications for percutaneous diskectomy 总被引:1,自引:0,他引:1
It has been recommended that computed tomography (CT) with the patient prone be performed in every patient undergoing percutaneous diskectomy; this would enable detection of a retrorenal location of the colon, which could interfere with the percutaneous procedure. In this evaluation of 346 prone CT studies, only one patient (0.29%) was found to have retrorenal or retropsoas bowel that would have been perforated at diskectomy. Because of this extremely low prevalence, the performance of prone CT in every patient undergoing percutaneous lumbar diskectomy is not believed to be necessary. 相似文献
9.
10.
PL Macken FRACO FRACS CJ Pavlin FRCS R Tuli MD GE Trope PhD FRCS 《Clinical & experimental ophthalmology》1995,23(3):217-220
Background: Spherophakia is an uncommon diagnosis. This is the first case report of spherophakia evaluated by ultrasound biomicroscopy.
Methods: Ultrasound biomicroscopy is a new diagnostic technique developed by one of the authors and provides images with microscopic resolution of the anterior segment. A patient with spherophakia was evaluated by ultrasound biomicroscopy (Zeiss-Humphrey, 50MHz) before and after YAG laser iridotomy.
Results: Ultrasound biomicroscopic assessment revealed a shallow anterior chamber, a very steep anterior lens curvature, iridolenticular contact, elongated zonules, and an increased distance between the lens equator and the ciliary processes. Angle closure glaucoma was due to a pupil block mechanism. The pupil block was relieved by YAG laser iridotomy.
Conclusions: Ultrasound biomicroscopy is a useful technique to confirm the diagnosis of spherophakia. The pupil block in spherophakia is relieved by YAG laser iridotomy. 相似文献
Methods: Ultrasound biomicroscopy is a new diagnostic technique developed by one of the authors and provides images with microscopic resolution of the anterior segment. A patient with spherophakia was evaluated by ultrasound biomicroscopy (Zeiss-Humphrey, 50MHz) before and after YAG laser iridotomy.
Results: Ultrasound biomicroscopic assessment revealed a shallow anterior chamber, a very steep anterior lens curvature, iridolenticular contact, elongated zonules, and an increased distance between the lens equator and the ciliary processes. Angle closure glaucoma was due to a pupil block mechanism. The pupil block was relieved by YAG laser iridotomy.
Conclusions: Ultrasound biomicroscopy is a useful technique to confirm the diagnosis of spherophakia. The pupil block in spherophakia is relieved by YAG laser iridotomy. 相似文献