全文获取类型
收费全文 | 2077篇 |
免费 | 329篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 64篇 |
妇产科学 | 287篇 |
基础医学 | 122篇 |
口腔科学 | 47篇 |
临床医学 | 861篇 |
内科学 | 238篇 |
皮肤病学 | 54篇 |
神经病学 | 37篇 |
特种医学 | 239篇 |
外科学 | 79篇 |
综合类 | 56篇 |
预防医学 | 145篇 |
眼科学 | 32篇 |
药学 | 82篇 |
中国医学 | 4篇 |
肿瘤学 | 59篇 |
出版年
2023年 | 44篇 |
2022年 | 6篇 |
2021年 | 21篇 |
2020年 | 40篇 |
2019年 | 31篇 |
2018年 | 75篇 |
2017年 | 97篇 |
2016年 | 87篇 |
2015年 | 111篇 |
2014年 | 115篇 |
2013年 | 118篇 |
2012年 | 62篇 |
2011年 | 81篇 |
2010年 | 122篇 |
2009年 | 113篇 |
2008年 | 59篇 |
2007年 | 74篇 |
2006年 | 54篇 |
2005年 | 36篇 |
2004年 | 30篇 |
2003年 | 46篇 |
2002年 | 24篇 |
2001年 | 38篇 |
2000年 | 13篇 |
1999年 | 49篇 |
1998年 | 94篇 |
1997年 | 109篇 |
1996年 | 105篇 |
1995年 | 94篇 |
1994年 | 63篇 |
1993年 | 49篇 |
1992年 | 25篇 |
1991年 | 26篇 |
1990年 | 10篇 |
1989年 | 33篇 |
1988年 | 31篇 |
1987年 | 20篇 |
1986年 | 27篇 |
1985年 | 30篇 |
1984年 | 13篇 |
1983年 | 13篇 |
1982年 | 18篇 |
1981年 | 12篇 |
1980年 | 15篇 |
1978年 | 16篇 |
1977年 | 17篇 |
1976年 | 13篇 |
1975年 | 15篇 |
1969年 | 4篇 |
1968年 | 6篇 |
排序方式: 共有2415条查询结果,搜索用时 15 毫秒
1.
2.
D Van Neste† RM Trüeb‡ 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):578-583
BACKGROUND: Computer-assisted image analysis has been proposed for human hair growth studies. METHODS: The performances of Trichoscan, a commercially available automated system combining epiluminiscence microscopy with digital image analysis, developed for office-based hair growth measurements, have been evaluated comparatively on the same skin sites using standardized photographic equipment and calibrated processing for contrast-enhanced phototrichogram (CE-PTG) analysis. This reference method has been validated with scalp biopsies and histological examination of serial sectioning. RESULTS: Besides edge effects, hair fibres escaped the Trichoscan analysis for various reasons including, but not limited to, thickness, pigmentation, closeness and crossing. CONCLUSION: Most of these problems have been identified in the late 1980s and remain largely unsolved by the processing software that was evaluated in 2004. Therefore claims promoting the Trichoscan method for accurate hair measurements in clinical trials on scalp and body hair are not supported by the present investigation. The speed at which the analysis is performed is outweighed by the errors in signal detection. Therefore we suggest that improvements must be clearly documented before Trichoscan is established for quantified diagnostic purposes and detailed hair cycle monitoring during hair trials. 相似文献
3.
4.
5.
Luiz H Castro Luiz K Ferreira Leandro R Teles Carmen L Jorge Paula R Arantes Carla R Ono Carla C Adda Rosa F Valerio 《Seizure》2007,16(1):50-58
PURPOSE: Hypothalamic hamartoma (HH) related epilepsy presents with gelastic seizures (GS), other seizure types and cognitive deterioration. Although seizure origin in GS has been well established, non-GS are poorly characterized. Their relationship with the HH and cognitive deterioration remains poorly understood. We analyzed seizure type, spread pattern in non-GS and their relationship with the epileptic syndrome in HH. METHODS: We documented all current seizure types in six adult patients with HH-epilepsy with video-EEG monitoring, characterized clinical-electrographic features of gelastic and non-gelastic seizures and correlated these findings with cognitive profile, as well as MRI and ictal SPECT data. RESULTS: Only four seizure types were seen: GS, complex partial (CPS), tonic seizures (TS) and secondarily generalized tonic-clonic seizures (sGTC). An individual patient presented either CPS or TS, but not both. GS progressed to CPS or TS, but not both. Ictal patterns in GS/TS and in GS/CPS overlapped, suggesting ictal spread from the HH to other cortical regions. Ictal SPECT patterns also showed GS/TS overlap. Patients with GS-CPS presented a more benign profile with preserved cognition and clinical-EEG features of temporal lobe epilepsy. Patients with GS-TS had clinical-EEG features of symptomatic generalized epilepsy, including mental deterioration. CONCLUSIONS: Video-EEG and ictal SPECT findings suggest that all seizures in HH-related epilepsy originate in the HH, with two clinical epilepsy syndromes: one resembling temporal lobe epilepsy and a more catastrophic syndrome, with features of a symptomatic generalized epilepsy. The epilepsy syndrome may be determined by HH size or by seizure spread pattern. 相似文献
6.
V Schleyer† S Radakovic-Fijan‡ S Karrer† T Zwingers§ A Tanew‡ M Landthaler† RM Szeimies† 《Journal of the European Academy of Dermatology and Venereology》2006,20(7):823-828
BACKGROUND: Based on good results in the treatment of superficial skin tumours, since the early 1990s topical photodynamic therapy with aminolaevulinic acid (ALA PDT) has been used for disseminated, inflammatory dermatoses including psoriasis. However, there is still a lack of well-documented trials. OBJECTIVE: A prospective randomized, double-blind phase I/II intrapatient comparison study was conducted in 12 patients to investigate whether topical ALA PDT is an effective treatment for chronic plaque-type psoriasis. METHODS: In each patient three psoriatic plaques were randomly treated with a light dose of 20 J/cm(2) and 0.1%, 1% and 5% ALA, respectively. Treatment was conducted twice a week until complete clearance or for a maximum of 12 irradiations. Therapeutic efficacy was assessed by weekly determination of the psoriasis severity index (PSI). RESULTS: The mean percentage improvement was 37.5%, 45.6% and 51.2% in the 0.1%, 1% and 5% ALA-treated groups, respectively. Irradiation had to be interrupted several times because of severe burning and pain sensation. CONCLUSION: Topical ALA PDT did not prove to be an appropriate treatment option for plaque-type psoriasis due to disappointing clinical efficacy, the time-consuming treatment procedure and its unfavourable adverse event profile. 相似文献
7.
8.
9.
10.
M.M. Bialoskurski MA RN RM C.L. Cox MSc PhD RN & R.D. Wiggins PhD 《Journal of advanced nursing》2002,37(1):62-69
AIM: The aim of this study was to investigate the nature and organization of maternal needs and priorities in a neonatal unit. BACKGROUND: The relationship between maternal needs and priorities appears to be an under studied area in neonatal nursing. METHODS: A quantitative survey was carried out based on 209 mothers with premature infants. Two self-assessment schedules were used: critical care maternal needs inventory (J. Leske, Heart and Lung 15, 27-42) and a ranking scale. The data were analysed with multivariate analysis. FINDINGS: Data analysis revealed clear priorities in maternal needs. In particular the need for accurate infant related information was a priority for 93% of the mothers. Good communication practices with professionals were also valued. The mothers displayed altruistic behaviour, and self-related needs took second place. It is proposed that maternal needs demonstrate a hierarchical organization. CONCLUSION: It is important for nurses to consider the individual needs of the mothers, simply because the satisfaction of these needs is essential for maternal well-being. 相似文献