首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   74684篇
  免费   3918篇
  国内免费   287篇
耳鼻咽喉   1104篇
儿科学   2290篇
妇产科学   3305篇
基础医学   10978篇
口腔科学   1763篇
临床医学   5843篇
内科学   15542篇
皮肤病学   1924篇
神经病学   7708篇
特种医学   1389篇
外科学   6583篇
综合类   354篇
现状与发展   1篇
一般理论   43篇
预防医学   6510篇
眼科学   1862篇
药学   6525篇
中国医学   164篇
肿瘤学   5001篇
  2023年   723篇
  2022年   1630篇
  2021年   2725篇
  2020年   1515篇
  2019年   1976篇
  2018年   2282篇
  2017年   1803篇
  2016年   1982篇
  2015年   2152篇
  2014年   2862篇
  2013年   3622篇
  2012年   5226篇
  2011年   5348篇
  2010年   2813篇
  2009年   2273篇
  2008年   3915篇
  2007年   4075篇
  2006年   3847篇
  2005年   3534篇
  2004年   3386篇
  2003年   3096篇
  2002年   2781篇
  2001年   925篇
  2000年   864篇
  1999年   813篇
  1998年   493篇
  1997年   321篇
  1992年   471篇
  1991年   399篇
  1990年   413篇
  1989年   476篇
  1988年   528篇
  1987年   508篇
  1986年   507篇
  1985年   480篇
  1984年   426篇
  1983年   321篇
  1979年   550篇
  1978年   347篇
  1977年   288篇
  1975年   355篇
  1974年   522篇
  1973年   526篇
  1972年   437篇
  1971年   408篇
  1970年   395篇
  1969年   416篇
  1968年   361篇
  1967年   280篇
  1966年   296篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Abstract

Supporting patients in making informed healthcare decisions is a cornerstone of ethical medical practice. Surgeons frequently draw for and show images to patients when consenting them for operations but the value of this practice in informed decision-making is unclear. An audit was conducted in a General Surgery Department. 244 patients completed questionnaires on the value of visual materials when giving consent for surgery. The complexity of the operations was classified into “simple”, “moderate” or “complex”. 100% of patients felt they had given informed consent to surgery. 62% of patients received at least one form of visual material during the consenting process. All patients who received a drawing, and 99% of those provided with other images, valued these resources. Visual materials were considered more useful to patients when giving consent for moderate or complex operations than simple ones. Approximately one third of patients who did not receive visual materials would have appreciated these when making an informed decision. This research highlights the value of surgeons drawing for, and providing other visual resources to, their patients as part of the consent process. There is a role for further research and training materials in drawing skills for surgeons.  相似文献   
3.
Quality of Life Research - The aim of the study was to assess QoL and identify and analyse its determinants in women with endometriosis. The study was performed in 2019 in health centres in Lublin...  相似文献   
4.
5.
6.
7.
8.
9.

Background

Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives

To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.

Methods

Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.

Results

Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.

Conclusions

These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号