全文获取类型
收费全文 | 23780篇 |
免费 | 1662篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 212篇 |
儿科学 | 841篇 |
妇产科学 | 783篇 |
基础医学 | 2826篇 |
口腔科学 | 581篇 |
临床医学 | 3249篇 |
内科学 | 4094篇 |
皮肤病学 | 267篇 |
神经病学 | 2435篇 |
特种医学 | 652篇 |
外国民族医学 | 11篇 |
外科学 | 2687篇 |
综合类 | 542篇 |
一般理论 | 34篇 |
预防医学 | 3240篇 |
眼科学 | 367篇 |
药学 | 1412篇 |
1篇 | |
中国医学 | 27篇 |
肿瘤学 | 1207篇 |
出版年
2023年 | 182篇 |
2022年 | 233篇 |
2021年 | 530篇 |
2020年 | 332篇 |
2019年 | 524篇 |
2018年 | 608篇 |
2017年 | 408篇 |
2016年 | 508篇 |
2015年 | 530篇 |
2014年 | 730篇 |
2013年 | 1041篇 |
2012年 | 1622篇 |
2011年 | 1660篇 |
2010年 | 825篇 |
2009年 | 729篇 |
2008年 | 1344篇 |
2007年 | 1441篇 |
2006年 | 1351篇 |
2005年 | 1279篇 |
2004年 | 1261篇 |
2003年 | 1135篇 |
2002年 | 1059篇 |
2001年 | 477篇 |
2000年 | 401篇 |
1999年 | 426篇 |
1998年 | 230篇 |
1997年 | 185篇 |
1996年 | 169篇 |
1995年 | 147篇 |
1994年 | 158篇 |
1993年 | 140篇 |
1992年 | 315篇 |
1991年 | 283篇 |
1990年 | 276篇 |
1989年 | 238篇 |
1988年 | 255篇 |
1987年 | 261篇 |
1986年 | 242篇 |
1985年 | 229篇 |
1984年 | 121篇 |
1983年 | 125篇 |
1982年 | 97篇 |
1981年 | 103篇 |
1980年 | 73篇 |
1979年 | 118篇 |
1978年 | 96篇 |
1974年 | 72篇 |
1973年 | 69篇 |
1972年 | 69篇 |
1971年 | 75篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease. Fluoxetine has been shown to increase hepatic lipid accumulation in vivo and in vitro. In addition, fluoxetine has been shown to alter the production of prostaglandins which have also been implicated in the development of non-alcoholic fatty liver disease. The goal of this study was to assess the effect of fluoxetine exposure on the prostaglandin biosynthetic pathway and lipid accumulation in a hepatic cell line (H4-II-E-C3 cells). Fluoxetine treatment increased mRNA expression of prostaglandin biosynthetic enzymes (Ptgs1, Ptgs2, and Ptgds), PPAR gamma (Pparg), and PPAR gamma downstream targets involved in fatty acid uptake (Cd36, Fatp2, and Fatp5) as well as production of 15-deoxy-Δ12,14PGJ2 a PPAR gamma ligand. The effects of fluoxetine to induce lipid accumulation were attenuated with a PTGS1 specific inhibitor (SC-560), whereas inhibition of PTGS2 had no effect. Moreover, SC-560 attenuated 15-deoxy-Δ12,14PGJ2 production and expression of PPAR gamma downstream target genes. Taken together these results suggest that fluoxetine-induced lipid abnormalities appear to be mediated via PTGS1 and its downstream product 15d-PGJ2 and suggest a novel therapeutic target to prevent some of the adverse effects of fluoxetine treatment. 相似文献
2.
James A. Akingbasote Alison J. Foster Ian Wilson Sunil Sarda Huw B. Jones J. Gerry Kenna 《Archives of toxicology》2016,90(4):853-862
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN?) mice exhibit normal hepatic and extrahepatic biotransformation enzyme activities when compared to wild-type (WT) mice, but express no functional hepatic cytochrome P450 activities. When incubated in vitro with [14C]-diclofenac, liver microsomes from WT mice exhibited extensive biotransformation to oxidative and glucuronide metabolites and covalent binding to proteins was also observed. In contrast, whereas glucuronide conjugates and a quinone-imine metabolite were formed when [14C]-diclofenac was incubated with HRN? mouse liver, only small quantities of P450-derived oxidative metabolites were produced in these samples and covalent binding to proteins was not observed. Livers from vehicle-treated HRN? mice exhibited enhanced lipid accumulation, bile duct proliferation, hepatocellular degeneration and necrosis and inflammatory cell infiltration, which were not present in livers from WT mice. Elevated liver-derived alanine aminotransferase, glutamate dehydrogenase and alkaline phosphatase activities were also observed in plasma from HRN? mice. When treated orally with diclofenac for 7 days, at 30 mg/kg/day, the severities of the abnormal liver histopathology and plasma liver enzyme findings in HRN? mice were reduced markedly. Oral diclofenac administration did not alter the liver histopathology or elevate plasma enzyme activities of WT mice. These findings indicate that HRN? mice are valuable for exploration of the role played by hepatic P450s in drug biotransformation, but poorly suited to investigations of drug-induced liver toxicity. Nevertheless, studies in HRN? mice could provide novel insights into the role played by inflammation in liver injury and may aid the evaluation of new strategies for its treatment. 相似文献
3.
Purpose
Chest wall pain is an uncommon but bothersome late complication following lung stereotactic body radiation therapy. Despite numerous studies investigating predictors of chest wall pain, no clear consensus has been established for a chest wall constraint. The aim of our study was to investigate factors related to chest wall pain in a homogeneous group of patients treated at our institution.Patients and methods
All 122 patients were treated with the same stereotactic body radiation therapy regimen of 48 Gy in three fractions, seen for at least 6 months of follow-up, and planned with heterogeneity correction. Chest wall pain was scored according to the Common Terminology Criteria for Adverse Events classification v3.0. Patient (age, sex, diabetes, osteoporosis), tumour (planning target volume, volume of the overlapping region between planning target volume and chest wall) and chest wall dosimetric parameters (volumes receiving at least 30, 40, and 50 Gy, the minimal doses received by the highest irradiated 1, 2, and 5 cm3, and maximum dose) were collected. The correlation between chest wall pain (grade 2 or higher) and the different parameters was evaluated using univariate and multivariate logistic regression.Results
Median follow-up was 18 months (range: 6–56 months). Twelve patients out of 122 developed chest wall pain of any grade (seven with grade 1, three with grade 2 and two with grade 3 pain). In univariate analysis, only the volume receiving 30 Gy or more (P = 0.034) and the volume of the overlapping region between the planning target volume and chest wall (P = 0.038) significantly predicted chest wall pain, but these variables were later proved non-significant in multivariate regression.Conclusion
Our analysis could not find any correlation between the studied parameters and chest wall pain. Considering our present study and the wide range of differing results from the literature, a reasonable conclusion is that a constraint for chest wall pain is yet to be defined. 相似文献4.
5.
6.
7.
8.
9.
10.