全文获取类型
收费全文 | 24058篇 |
免费 | 1393篇 |
国内免费 | 480篇 |
专业分类
耳鼻咽喉 | 217篇 |
儿科学 | 344篇 |
妇产科学 | 314篇 |
基础医学 | 3162篇 |
口腔科学 | 511篇 |
临床医学 | 2014篇 |
内科学 | 5611篇 |
皮肤病学 | 382篇 |
神经病学 | 1754篇 |
特种医学 | 950篇 |
外国民族医学 | 1篇 |
外科学 | 3162篇 |
综合类 | 1215篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 1104篇 |
眼科学 | 560篇 |
药学 | 2003篇 |
5篇 | |
中国医学 | 437篇 |
肿瘤学 | 2182篇 |
出版年
2023年 | 155篇 |
2022年 | 291篇 |
2021年 | 559篇 |
2020年 | 298篇 |
2019年 | 440篇 |
2018年 | 480篇 |
2017年 | 372篇 |
2016年 | 432篇 |
2015年 | 533篇 |
2014年 | 689篇 |
2013年 | 744篇 |
2012年 | 1163篇 |
2011年 | 1244篇 |
2010年 | 739篇 |
2009年 | 608篇 |
2008年 | 989篇 |
2007年 | 1158篇 |
2006年 | 1042篇 |
2005年 | 1046篇 |
2004年 | 1108篇 |
2003年 | 1136篇 |
2002年 | 1097篇 |
2001年 | 1016篇 |
2000年 | 936篇 |
1999年 | 758篇 |
1998年 | 280篇 |
1997年 | 243篇 |
1996年 | 244篇 |
1995年 | 200篇 |
1994年 | 182篇 |
1993年 | 142篇 |
1992年 | 523篇 |
1991年 | 529篇 |
1990年 | 492篇 |
1989年 | 469篇 |
1988年 | 365篇 |
1987年 | 339篇 |
1986年 | 360篇 |
1985年 | 337篇 |
1984年 | 230篇 |
1983年 | 195篇 |
1982年 | 100篇 |
1980年 | 99篇 |
1979年 | 177篇 |
1978年 | 116篇 |
1977年 | 110篇 |
1974年 | 99篇 |
1972年 | 106篇 |
1969年 | 98篇 |
1968年 | 104篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Yan Gao Shi-Feng Chu Zhao Zhang Qi-Di Ai Cong-Yuan Xia Hui-Yong Huang 《Journal of Asian natural products research》2019,21(8):782-797
Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality secondary to hepatic necrosis. Ginsenoside Rg1 is a major active ingredient in processed Panax ginseng, which is proved to elicit biological effects. We hypothesized the beneficial effect of Rg1 on APAP-mediated hepatotoxicity was through Nrf2/ARE pathway. The study was conducted in cells and mice, comparing the actions of Rg1. Rg1 significantly improved cell survival rates and promoted the expression of antioxidant proteins. Meanwhile, Rg1 reduced the excessive ROS and the occurrence of cell apoptosis, which were related to Nrf2/ARE pathway. Expression of Nrf2 has a certain cell specificity.
2.
Hideyuki Masuda Makoto Kimura Akiko Nishioka Hiroshi Kato Akimichi Morita 《Journal of dermatological science》2019,93(2):109-115
Background
Photosensitizers used for photodynamic therapy (PDT) to treat dermatologic disease are metabolized into mainly protoporphyrin IX (PpIX), which has five absorption wavelength peaks: 410?nm, 510?nm, 545?nm, 580?nm, and 630?nm. Although only red light around 635?nm and blue light around 400?nm are used as light sources for PDT, the efficiency of PDT might be improved by using multiple wavelengths, including those that correspond to the other absorption peaks of PpIX. Furthermore, because the target disease often occurs on the face, a flexible-type light-source unit that can be fitted to the lesion without unnecessarily exposing the mucous membranes, e.g., the eyes, nostrils, and mouth, is preferred.Objective
We investigated the efficacy of a flexible light-emitting diode (LED) unit that emits multiple wavelengths to improve PDT effects.Methods
HaCaT cells were incubated with 5-ALA and subsequently irradiated with either a single wavelength or sequentially with two wavelengths. Cell viability and reactive oxygen species were analyzed. Nude mice were implanted with COLO679 cells by subcutaneous injection into the flank. 5-ALA was subcutaneously injected into the tumor. The tumor was irradiated with 50?J/cm2 (day 0) and assessed daily until day 21.Results
The synergistic PDT effects of dual-wavelength irradiation and reactive oxygen species production were highest with the 405-nm and 505-nm wavelength combination. This dual wavelength combination was also the most effective in vivo.Conclusion
We could therefore conclude that dual-wavelength PDT is an efficient strategy for improving the therapeutic effects of PDT. Using a flexible LED unit is expected to achieve more uniform irradiation of uneven areas. 相似文献3.
4.
5.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献6.
<正>Stroke is a leading cause of mortality and severe neurological disability worldwide; however, curative therapeutic options are limited. Although recanalization therapy using endovascular thrombectomy has demonstrated great benefits in the functional outcome of patients with acute ischemic stroke, the rate of excellent clinical outcomes remains limited. Therefore, the current recanalization 相似文献
7.
8.
目的探讨自血穴位注射疗法联合马来酸茚达特罗治疗老年稳定期慢性阻塞性肺疾病(COPD)的临床疗效及其对患者炎性因子、免疫功能及肺功能的影响。 方法将2015年5月至2016年5月我院收治的86例老年缓解期COPD患者分为观察组与对照组。对照组给予马来酸茚达特罗治疗,观察组在对照组治疗基础上另给予自血穴位注射疗法。治疗12周后,评价2组临床疗效。治疗前及治疗12周后,分别检测2组患者肺功能指标(FEV1、FVC与PEF),炎性因子(IL-8、α1-AT、IL-6及TNF-α),免疫功能指标(IgG、IgA、CD3+及CD4+)水平。治疗期间,对2组患者的不良反应进行密切观察。 结果治疗后二组患者各项检测指标均优于治疗前。治疗12周后,观察组总有效率为90.7%,明显高于对照组的72.1%(P<0.05)。治疗12周后,观察组FEV1、FVC与PEF等肺功能指标,IgG、IgA、CD3+及CD4+等免疫功能指标水平均明显高于对照组(P<0.05),而IL-8、α1-AT、IL-6及TNF-α含量分别为(23.23±3.87)ng/L、(3.43±0.41)g/L、(52.25±5.38)ng/L及(43.12±3.98)ng/L,改善程度均明显优于对照组(P<0.05)。治疗期间,2组患者均未出现严重不良反应。 结论自血穴位注射疗法联合马来酸茚达特罗治疗老年稳定期COPD疗效确切,可有效改善患者炎症水平,值得进行深入研究。 相似文献
9.
John Lennon Silva Cunha Amanda Almeida Leite Thamiris de Castro Abrantes Lorena Passoni Vervloet Thayn Melo de Lima Morais Gerson de Oliveira Paiva Neto Tatiana Nayara Librio Kimura Snia Maria Soares Ferreira Ricardo Luiz Cavalcanti de Albuquerque‐Júnior Aline Corrêa Abraho Mario Jos Romaach Bruno Augusto Benevenuto de Andrade Oslei Paes de Almeida Ciro Dantas Soares 《Journal of cutaneous pathology》2021,48(1):24-33
10.
Hiroto Kinoshita Hitomi Nishioka Aya Ikeda Kyoko Ikoma Yoichi Sameshima Hidehisa Ohi Mizuki Tatsuno Junka Kouyama Chiaki Kawamoto Tomohiro Mitsui Yuko Tamura Yu Hashimoto Masashi Nishio Tsuyoshi Ogashiwa Yusuke Saigusa Shin Maeda Hideaki Kimura Reiko Kunisaki Kazuhiko Koike 《Journal of gastroenterology and hepatology》2019,34(11):1929-1939