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1.
陶娟 《中国煤炭工业医学杂志》2004,7(12):1215-1215
20 0 1年 4月— 2 0 0 4年 7月我院采用改良式剖宫产术 ,取得了良好的临床效果 ,现分析报告如下。1 资料与方法1.1. 一般资料 本组 2 97例 ,随机分为三组。改良式剖宫产(观察 )组 182例 ,年龄 2 3~ 4 2岁 ,初产妇 14 0例 ,经产妇 4 2例 ;腹部直切口剖宫产 (对照A)组 6 3例 ,年龄 2 1~ 38岁 ,初产妇 5 0例 ,经产妇 13例 ;腹部横弧形切口剖宫产 (对照B)组5 2例 ,年龄 2 3~ 33岁 ,初产妇 4 8例 ,经产妇 4例。三组产妇均具有头盆不称、胎儿宫内窘迫、臀位、妊娠高血压综合征、前置胎盘、过期妊娠等剖宫产指征。三组产妇年龄、孕产次、孕… 相似文献
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目的研究品管圈(quality control circle,QCC)活动在降低血液透析过程中低血压发生率的应用价值。方法选取在本院实施血液透析患者60例,将其随机分为研究组与对照组,每组患者30例。将常规血液透析护理应用于对照组患者中,研究组患者则开展QCC活动,比较组间患者在透析过程中低血压发生率。结果研究组低血压发生率为3.3%,对照组为23.3%,研究组结果显著低于对照组,差异存在统计学意义(P<0.05)。结论QCC活动的开展能有效降低血液透析患者血透过程中低血压的发生率,进而提升患者生存质量,提高患者满意度,具有一定临床应用价值。 相似文献
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神经系统受累是系统性红斑狼疮患者残疾、死亡的重要原因之一,临床表现为一系列高度异质性的神经精神症状.其中精神症状主要包括精神病、急性意识错乱状态、情绪障碍、认知功能障碍和焦虑症.然而,当前仍缺乏相关的诊断标准和治疗准则,导致对精神狼疮患者的诊断不足和治疗不当.因此,本文围绕精神狼疮展开综述,促进患者及临床医生对其的认识... 相似文献
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目的 通过肝癌多学科协作(multi-disciplinary team,MDT)诊治模式下实施规范抗乙肝病毒方案在肝癌病人中的应用,探讨抗乙肝治疗与肝癌术后生存率及肿瘤复发的关系。方法 回顾性分析2015年1月至2017年12月经我院肝癌MDT讨论后实施规范抗乙肝治疗病人(治疗组,36例)和未进行规范抗乙肝治疗病人(对照组,34例)的临床资料,比较两组病人肝癌术后肿瘤复发情况及1、3、5年内生存率。结果两组病人一般情况、实验室指标、肿瘤大小及术前HBV-DNA差异无统计学意义(P> 0.05),手术后为期5年的随访中治疗组病人1、3、5年肿瘤复发率分别为8.3%、33.3%、41.6%;对照组1、3、5年肿瘤复发率分别为11.7%、41.1%、64.7%,差异均具有统计学意义(P <0.05)。治疗组病人1、3、5年生存率分别为91.6%、66.7%、58.3%;对照组1、3、5年生存率分别为88.2%、58.8%、29.5%,差异均具有统计学意义(P <0.05)。结论 HBV相关性肝癌病人在经过肝癌MDT制定方案,术前和术后实施规范抗乙肝病毒治疗,可有效降低肝癌... 相似文献
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Objective To investigate the effects ofendothelin-1 (ET-1) and endothelin-3 (ET-3) on the expression of transformation growth factor-beta 1 (TGF-β1) and phosphorylation of Smad 3 in malignant melanoma cell line, A375. Methods Cultured A375 cells were classified into 5 groups, i.e. control group (no stimulation), ET-1 group (stimulated with ET-1), ET-1+BQ123 group (treated with ET-1 and BQ123),ET-1 + BQ788 group (treated with ET-1 and BQ788), ET-3 group (stimulated with ET-3), to receive different stimulation. The working concentrations were 0, 0.1, 1, 10, 100 nmol/L for ET-1 and ET-3, 10 μmol/L for BQ123 and BQ788. After another 12- and 24-hour culture, ELISA, RT-PCR and Western blot were used to detect the expression of TGF-β1 protein and mRNA as well as phosphorylated Smad 3 (P-Smad 3). Results The expression of TGF-β1 in A375 cells was up-regulated by ET-1, but down-regulated by ET-3, and both of the effects were in a concentration-dependent manner. Under the stimulation with ET-1 and ET-3 of 100 nmol/L, the level of TGF-β1 reached 1289.38 ± 89.42 ng/L per 105 cells and 85.09 ± 9.37 ng/L per 105 cells, respectively, significantly different from that in unstimulated cells (both P < 0.05). BQ123 signifi-cantly blocked the up-regnlatory effect of ET-1 on the expression TGF-β1 protein(P < 0.05), but BQ788 had no significant influence on the effect, so was the case with TGF-β1 mRNA. Western blot revealed that ET-1significantly elevated the expression of P-Smad 3 in A375 cells (P <0.05), and the elevation was significantly inhibited by BQ123, but not by BQ788. The expression of P-Smad 3 was statistically decreased by ET-3 in A375 cells (P <0.05). Conclusions The expression of TGF-β1 could be enhanced by ET-1, but suppressed by ET-3. It is likely that endothelin receptor A mediates the phosphorylation of Smad 3 induced by ET-1. 相似文献
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Objective To investigate the effects ofendothelin-1 (ET-1) and endothelin-3 (ET-3) on the expression of transformation growth factor-beta 1 (TGF-β1) and phosphorylation of Smad 3 in malignant melanoma cell line, A375. Methods Cultured A375 cells were classified into 5 groups, i.e. control group (no stimulation), ET-1 group (stimulated with ET-1), ET-1+BQ123 group (treated with ET-1 and BQ123),ET-1 + BQ788 group (treated with ET-1 and BQ788), ET-3 group (stimulated with ET-3), to receive different stimulation. The working concentrations were 0, 0.1, 1, 10, 100 nmol/L for ET-1 and ET-3, 10 μmol/L for BQ123 and BQ788. After another 12- and 24-hour culture, ELISA, RT-PCR and Western blot were used to detect the expression of TGF-β1 protein and mRNA as well as phosphorylated Smad 3 (P-Smad 3). Results The expression of TGF-β1 in A375 cells was up-regulated by ET-1, but down-regulated by ET-3, and both of the effects were in a concentration-dependent manner. Under the stimulation with ET-1 and ET-3 of 100 nmol/L, the level of TGF-β1 reached 1289.38 ± 89.42 ng/L per 105 cells and 85.09 ± 9.37 ng/L per 105 cells, respectively, significantly different from that in unstimulated cells (both P < 0.05). BQ123 signifi-cantly blocked the up-regnlatory effect of ET-1 on the expression TGF-β1 protein(P < 0.05), but BQ788 had no significant influence on the effect, so was the case with TGF-β1 mRNA. Western blot revealed that ET-1significantly elevated the expression of P-Smad 3 in A375 cells (P <0.05), and the elevation was significantly inhibited by BQ123, but not by BQ788. The expression of P-Smad 3 was statistically decreased by ET-3 in A375 cells (P <0.05). Conclusions The expression of TGF-β1 could be enhanced by ET-1, but suppressed by ET-3. It is likely that endothelin receptor A mediates the phosphorylation of Smad 3 induced by ET-1. 相似文献
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银屑病是一种慢性炎症性皮肤病,常累及指(趾)甲。银屑病甲损害不仅影响美观,还会引起疼痛和(或)功能障碍,严重影响患者的生活质量,且是银屑病关节损害的独立预测因素。甲的结构及甲床的低渗透性使甲银屑病的治疗充满挑战。常规治疗包括局部外用药物、皮损内注射及系统药物治疗等,治疗周期较长,患者用药依从性差。近年来,随着生物制剂的问世,极大地提高了银屑病患者的临床疗效,同时也对银屑病甲损害有所改善,但在国内整体使用率不高,尚缺乏针对甲银屑病的疗效及安全性的循证医学证据。该文就国内外生物制剂在甲银屑病中的应用做一阐述,以期为临床医生提供帮助。 相似文献