中药内服外敷对慢性骨髓炎新生血管的调控机制的探讨

Objective To observe the effect of traditional Chinese medicine internal and external treatment on chronic osteomyelitis.Method Chronic osteomyelitis experimental animal models were set up with debridement, then it was random divided into two groups ( antibiotics group for the control group, antibiotics and traditional Chinese medicine group for the observation group).After treatment for 10 days, new capillaries in the tissues surrounding sinus crossings were detected by pathological observation and VEGF expression was determined by ELISA.Result VEGF expression and vascular points of tissues surrounding sinus crossings of antibiotics with traditional Chinese medicine group were obviously higher than that of antibiotics group[ (47.48 ±3.22) μg/ml vs (28.26 ±2.61)μg/ml, P ＜0.01;8.03 ±1.73 vs5.17 ±2.89, P＜0.05 ].Conclusion Traditional Chinese medicine internal and external treatment can improve VEGF expression and increase capillary number inside tissues surrounding sinus.crossings , thus it can promote the healing of chronic osteomyelitis.     

中药内服外敷对慢性骨髓炎新生血管的调控机制的探讨

目的 观察中药内服外敷对慢性骨髓炎治疗的作用.方法 建立慢性骨髓炎实验动物模型再清创,随机分为两组（抗生素组为对照组,抗生素加中药组为观察组）,分别干预10 d后取窦道口周围组织行病理切片观测新生微血管,用ELISA法检测EVGF的表达.结果 抗生素加中药组的VEGF的表达及窦道口周围血管积分较抗生素组明显升高[（47.48±3.22）μg/ml vs（28.26±2.61）μg/ml,P＜0.01;8.03±1.73 vs 5.17±2.89,P＜0.05].结论 中药内服外敷可以提高VEGF的表达和窦道口周围组织内毛细血管数量,从而促进慢性骨髓炎的愈合.     

桃红四物汤对大鼠显微吻合血管内皮修复及血浆VEGF表达的影响

血管内皮生长因子（VEGF）是目前已知活性最强、专属性最高的血管生成因子。有研究提示VEGF可能在缺血及其相关性疾病发病机制中具有一定的作用,故笔者通过测定显微吻合大鼠血管处血浆VEGF水平,观察显微吻合血管内皮修复情况,以此探讨VEGF在缺血性相关疾病中的作用机制,现介绍如下。     

自拟膝关节炎熏洗方治疗膝关节骨性关节炎的临床观察

〔摘 要〕 目的：观察自拟膝关节炎熏洗方治疗膝关节骨性关节炎的疗效。 方法：选择 2017 年 5 月至 2019 年 1 月株洲 市中医伤科医院收治的 90 例膝关节骨性关节炎患者,随机分为观察组和对照组,各 45 例。观察组采用玻璃酸钠关节腔内 注射联合自拟膝关节炎熏洗方治疗,对照组仅给予玻璃酸钠关节腔内注射治疗,连续治疗 5 周。治疗结束后观察两组患者 症状体征积分改善情况及临床疗效。 结果：治疗前两组患者症状体征积分比较,差异无统计学意义（P ＞ 0.05）;治疗后 观察组和对照组症状体征积分较治疗前均明显降低,且观察组明显低于对照组,差异具有统计学意义（P ＜ 0.05）。观察 组患者治疗总有效率为 93.33 %,明显高于对照组的 51.11 %,差异具有统计学意义（P ＜ 0.05）。 结论：临床膝关节骨性 关节炎治疗中,玻璃酸钠关节腔内注射联合自拟膝关节炎熏洗方治疗,治疗效果较好。     

全膝关节置换术治疗老年重度膝关节炎伴胫骨平台骨折

目的探讨全膝关节置换术(TKA)治疗老年重度膝关节炎伴胫骨平台骨折的可行性。方法对19例重度膝关节炎伴胫骨平台骨折的老年患者进行TKA治疗,评估患者术后3、6个月时膝关节屈膝范围及HSS评分。结果患者均获得随访,时间6个月~3年。患者术后3个月膝关节屈伸范围95°~100°,HSS评分为82~90分;术后6个月膝关节屈伸范围100°~120°,HSS评分为85~96分,均达到满意的临床效果。结论TKA治疗老年重度膝关节炎伴胫骨平台骨折,患者关节功能恢复好,满意度高,不增加额外的手术风险。     

多发伤合并锁骨双极骨折1例

<正>患者,男,57岁。因骑摩托车翻车致头、膝以及左肩部受伤1d后转入我院。查体:神志清楚,头面部见多处皮肤擦伤,左胸锁关节处隆凸畸形,骨擦感,压痛明显,左肩锁关节处稍肿胀,压痛,左上肢活动受限,左膝关节肿胀,畸形。外院X线、CT检查示:左锁骨胸骨端骨折,左胫骨平台骨折,上颌窦骨折并积液。临床诊断:多发伤:1左胫骨平台骨折;2左锁骨胸骨端骨折,左锁骨肩     

中药内服外敷对慢性骨髓炎新生血管的调控机制的探讨

Objective To observe the effect of traditional Chinese medicine internal and external treatment on chronic osteomyelitis.Method Chronic osteomyelitis experimental animal models were set up with debridement, then it was random divided into two groups ( antibiotics group for the control group, antibiotics and traditional Chinese medicine group for the observation group).After treatment for 10 days, new capillaries in the tissues surrounding sinus crossings were detected by pathological observation and VEGF expression was determined by ELISA.Result VEGF expression and vascular points of tissues surrounding sinus crossings of antibiotics with traditional Chinese medicine group were obviously higher than that of antibiotics group[ (47.48 ±3.22) μg/ml vs (28.26 ±2.61)μg/ml, P ＜0.01;8.03 ±1.73 vs5.17 ±2.89, P＜0.05 ].Conclusion Traditional Chinese medicine internal and external treatment can improve VEGF expression and increase capillary number inside tissues surrounding sinus.crossings , thus it can promote the healing of chronic osteomyelitis.