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非特异性肝病抗原(Ar-Ag)研究(一),对该抗原的参考血清的建立、检测 Ar-Ag 的方法及其与 HBeAg 的鉴别如前文报告。本文将其临床分布及意义的研究结果报告如下。材料和方法1.Ar-Ag(79—1)和 Ar—Ab(79—2)参考血清:Ar-Ag 为—乙型慢性活动型肝炎患者血清,Ar-Ab 为—乙型急性肝炎恢 相似文献
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比较乙型肝炎表面抗原亚性特征,对了解不同亚型优势地区肝炎交叉传染的可能性是一项可靠的血清学证明,本文报告93名西藏地区青年学员,在北京、河南学习六年后,所见肝炎流行的一些特点。 相似文献
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报告协作检测全国28个省、市,自治区18个民族3984份 HBsAg 阳性血清标本,应用琼脂扩散法进行乙型肝炎表面抗原亚型检测结果,发现我国存在着三个亚型优势地区。分析不同亚型的临床表现与 e 抗原系统的关系提示我国的优势亚型 adr 型可能较 adw 型易导致慢性肝病。观察在一次肝炎流行中检测亚型分布,发现二种亚型并存,而同宿舍中的续发病例与原发病例为同一亚型,从而证明密切生活接触是这次传播的原因。研究亚型在 HBV 传递过程中的变化,观察 ayw 亚型区人群在 adr 优势区生活六年所感染的肝炎仍为 ayw 型。由 ayw 优势区迁移至 adr 优势区的蒙族六百年后为 adr 优势。指出我国为多亚型国家,亚型间的交叉免疫性对乙型肝炎的流行病学的意义及疫苗制备所需要的亚型合理选择皆待深入研究。 相似文献
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Mai Kai买凯and Xie Changyi谢长义Hepatitjs Dtvision Henan MedicaL College Provincial Institute of Medieat Scienees Zhengzhou 《中华医学杂志(英文版)》1979,92(10):709-718
Serum samplcs from asymptomatie IIBsAg
carriers and patients with various forms of
livcr di.seases were studied by agar gel diffu-
sion tcchnique for the incidence rate of e
system. and correlation with other marlicrs of
HBV infection. 5% ot eAg and 30% of eAb in
181 asymptomatic HBsAg carriers and 24% of
eAg aml O.7% of eAb in 583 cases with vanous
forms of liver diseases were detected. Presence
of eAg was associated with DNA-polymerase
ar.tivity arid in the majority of circulating Dane
particles. 91% of e system positive sera be-
longetl tD AD-subtYPC of HBsAg which had
bccn reparted to he the dominating subtype
of HBsAg in this part of the country,99% eAg-
positive sera of 11 HBsAg(+) liver cancers and
50%" eAb in Z such cases tested had high level
(80,000 ng) of AFP in t,heir sera. Although AFP
was detected in 66clo of 18 HBsAg{+).eAg(+)
chrortic hepatitis patients and in ZOc!e of ZO
I'IBsAg{+).eAg{+) healthy carriers, the level
of AFP was very low (>100 ng).
Anti-HBe was detected in 100% of
HBsAg(十).eAg{+) sera tested, ancl DNA-
polymerase activity (7o ng) was also detected
in all of these sera. Anti-HBe was tletected
in all 6 HBsAg(+).e systemH sera tested,
but iONA-polymerase activity was shown iri
only half of these sera.
From the above results it seems justifled
to conclude that eAg is highllr associaterl with
chronic heDatitis and eAb does so only vith
asympfomaLic IIBsAtf carriers, aiiit that anti-
HBc is a sensitive indicator of HBV infection,
regardless of whether e system is preseut or
not. 3Ft is noticeable that both eAg and eAb
were associated with HBsAg(+) primary he-
Patocellular carcinom.
The generation oI e systerrt and results of
our e system test in comparison with that of
others are briefly discussed. 相似文献
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藤松等1976年在e抗原和e抗体检测时,发现一种抗原与已知的HBV(乙型肝炎病毒)各种抗原系统完全不同,且在乙型肝炎以外的各种肝病中亦有发现,故以该抗原携带者Arai名字命名。后古田、腾原、藤松等相继对该抗原系统的理化特性、临床分布及意义作了系统的观察研究。现将有关Arai 相似文献
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本文报告我国十二个省区194份阳性标本中,乙型肝炎抗—HBc与乙型肝炎表面抗元抗体及e抗元抗体间的关系。对比观察表明抗—HBc滴度与HBsAg滴度、e系统有密切关系,而与HBsAg亚型、SGPT无明显关系;抗—HBc较HBsAg、e系统及SGPT反映HBV复制更确切,高滴度抗—HBc的慢性携带者有发展为慢性肝病的可能。並指出抗—HBc是乙型肝炎的一项敏感而特异的检测方法。 相似文献
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