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新型冠状病毒(简称新冠病毒)奥密克戎(Omicron)变异株感染在特定人群中可引发严重危害并危及生命。Omicron变异株感染可导致进展迅速的系统性炎症反应、凝血功能异常及多器官功能损伤等病理生理改变, 提示其危重症病例的临床治疗与新冠病毒其他毒株所致疾病有所不同。国家重大公共卫生事件医学中心组织感染科、呼吸科、重症医学科、儿科和发热门诊科等专家, 基于目前的循证医学证据及大量临床实践, 撰写本快速指引, 以期规范、有效提升新冠病毒Omicron变异株感染的临床救治能力。 相似文献
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The distribution of hepatitis B virus genotype in Hubei province and its clinical signifi- cance were investigated. HBV genotypes of 276 patients were detected by PCR-microplate sandwich hybrization-ELISA technique. The level of HBV DNA was detected by using PCR-fluorescence quantification test. Among 276 patients, there were 78 cases of HBV asymptomatic carriers, 110 cases of chronic hepatitis B (CHB), 62 cases of severe hepatitis (SH) or liver cirrhosis (LC) and 26 cases of hepatocellular carcinoma (HCC). The genotypes of HBV included C, B, mixtures (B C, B D, C D) and D, accounting for 55.8%, 25.4%, 16.7% and 2.1% respectively. The average level of HBV DNA in genotypes C, B, mixtures and D was 1.20×106, 7.81×104, 3.26×105 and 5.01×104 cop- ies/mL respectively. The ratio of SH, LC and HCC in genotype B, C and mixtures was 20%, 30% and 48% respectively. Statistical analysis revealed the percentage of genotype mixtures infection was sig- nificantly higher than that of genotype B infection. There was no significant difference in the per- centage between genotype B and genotype C or between genotype C and mixtures. The distribution of genotype B, C and mixtures in SH, LC and HCC was significantly different. The frequency of HCC was zero in patients with co-infection. Genotype D was only related with SH and LC. The in- creased ALT could be converted to categorical grades of severity. From mild, moderate to severity, the prevalence of genotype C showed an opposite trend, although no statistically significant differ- ence was observed. The HBeAg positive rate was higher in patients with genotype C infection than in those with genotype B, especially in the patients whose ages were from 31 to 40 years old. Compared with genotype B, genotype C showed a higher HBeAg positive rate in patients with SH and LC. The percentage of SH, LC and HCC was higher in patients with genotype C and mixtures infection. On the contrary, the percentage of genotype B was lower. The HBeAg positive rate in patients with genotype C infection was higher than those with genotype B infection. Genotype C and mixtures may be associated with development of severe liver disease. 相似文献
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血吸虫病患者吡喹酮治疗后外周血T细胞亚群的检测 总被引:2,自引:0,他引:2
应用碱性磷酸酶抗碱性磷酸酶桥联酶标法对18例慢性血吸虫病患者,22例晚期血吸虫病患者进行了吡喹酮治疗前后的外周血T细胞亚群检测,发现治疗前慢血,晚血CD^+3,CD^=8百分比均显著升高,与对照组比较有显著性差异。CD^+4百分比低于对照组,无显著性差异。 相似文献
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应用碱性磷酸酶抗碱性磷酸酶(APAAP)桥联酶标法对18例慢性血吸虫病(慢血)患者,22例晚期血吸虫病(晚血)患者进行了吡喹酮治疗前后的外周血T细胞亚群检测,发现治疗前慢血、晚血CD3+、CD8+百分比均显著升高,与对照组比较有显著性差异。CD4+百分比低于对照组,无显著性差异。治疗3个月后检查,两组CD4+上升、CD8+减少,其百分比基本达到正常水平,CD4+/CD8+比值上升高于对照组,有显著性差异。结果提示,吡喹酮治疗血吸虫病可能具有参与免疫调节、增强T淋巴细胞功能的作用,但不能改善免疫紊乱。 相似文献
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干扰素抗性和病毒性肝炎 总被引:1,自引:0,他引:1
干扰素(IFN)对各种病毒性肝炎及相关肝病都有不同程度的疗效。但是长期使用失效及疾病复发成为IFN治疗的重大缺陷。IFN抗性具有多种机制,本文就IFN抗体的产生、Ⅰ型IFN受体表达的下降、病毒蛋白的干扰和前炎性因子的表达显著增高4个方面进行综述。 相似文献
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Study on the
Correlation of Plasma NO, ET-1 and ALT in the Patients with Chronic Hepatitis and
Cirrhosis 总被引:3,自引:0,他引:3
Nitric oxide ( NO) is a small molecular sub-stance with many biological functions.NO is an un-stable molecule with free radical( or group) struc-ture. Its half life in vivo is 1 to 5s and is reduced tothe stable terminal products( NO2 -/NO3 -) quickly.Atpresent,many researchers reported that the levelof NO is related with the degree of liver disease. Wedetermined the levels of NO,endothelin- 1 ( ET- 1 )and ALT in the in- patients with chronic hepatitis Band active cirrhosisand analyze t… 相似文献
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茵栀黄注射液系中药有效成分提取物制成的注射液,其主要成分包括黄芩甙、茵陈、栀子,因其有清热、解毒。利湿等功能,目前在临床上广泛用于急、慢性肝炎和重型肝炎,作为退黄的主要药品之一。由于个体差异及药品纯度等原因,临床上少数患者(约3%以下)在使用中有皮疹等过敏反应,也有极少数病人出现输液反应,上述不良反应经停药及抗过敏治疗后均可缓解。最近我们在治疗肝硬变病人过程中,出现1例特殊不良反应者,现报道如下。 患者男性,45岁,临床诊断:慢性乙型病毒性肝炎(重度)、肝炎肝硬变,既往无心血管疾病病史,治疗在降酶、退黄、对症等综合治疗基础上,同时应用茵栀黄,1周内患者未出现任何不良反应,1周后在输茵栀黄过程中,患者逐渐出现胸骨 相似文献
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人粒细胞无形体病研究进展 总被引:1,自引:0,他引:1
人类粒细胞无形体病(human granulocytic anaplasmosis.HGA)是一类新发的重要的人兽共患自然疫源性疾病,由嗜吞噬细胞无形体(anaplasma phagocytophilium,AP)引起,主要侵染人末梢血中性粒细胞,经蜱源传播的埃立克体疾病. 相似文献