可定与立普妥治疗冠心病的疗效对比研究

目的:对比分析可定和立普妥对冠心病患者的疗效.方法:选择2013年4月至2015年4月来该院行治疗的150例冠心病患者为研究对象,随机等分两组,在常规治疗的基础上,分别给以可定和立普妥治疗,疗程一年,分别于治疗前、治疗后一年检测患者血脂、超敏C反应蛋白(hs-CRP) 、同型半胱氨酸(Hcy) 及颈动脉内膜中层厚度 (IMT).结果:治疗后,组内比较治疗前和治疗后1年比较差别有统计学意义(P<0.05) ,一年后治疗效果,组间比较显示,可定组的改善效果明显优于立普妥组,差异也有统计学意义(P<0.05) .结论:可定和立普妥均能有效改善冠心病患者血脂水平、降低高敏C反应蛋白和同型半胱氨酸浓度,对缓解动脉粥样硬化有一定的作用,且可定效果更加显著.     

动态血压变异性与主观认知下降进展的相关性CSCD

Objective To analyze the correlation between ambulatory blood pressure variability and the progression of subjective cognitive decline (SCD). Methods In this prospective observational study, the overall sampling method was used to continuously select 100 patients with SCD in the Department of Neurology, Changshu First People′s Hospital and Changshu Xinzhuang People′s Hospital from January 1 2016 to June 30 2017. The baseline demographic characteristics of the patients were collected. The Chinese version of SCD‑Q9 questionnaire was used to self‑evaluate SCD, and the Montreal Cognitive Assessment Scale (MoCA) was used to evaluate objective cognitive impairment. All patients received 24 h ambulatory blood pressure monitoring, and 24 h systolic coefficient of variation (SCV) and diastolic coefficient of variation (DCV) were calculated. The follow‑up period was 4 years after the first visit, and the MoCA scale was evaluated once a year. Finally, 83 patients completed the follow‑up and were included in this study. According to the MoCA score at the end of follow‑up (<26 or ≥26), the patients were divided into progression group (39 cases) and non‑progression group (44 cases). The difference of MoCA score between baseline and last follow‑up was calculated in the progression group. The difference in demographic characteristics between the two groups was compared with χ2 test. The difference of 24 h SCV and 24 h DCV between the two groups were compared by rank sum test. The correlation between 24 h SCV and MoCA score difference or SCD‑Q9 score in the progression group were tested by multiple linear regression analysis. Results The 4‑year progression rate of SCD patients was 46.99% (39/ 83). There was no significant differences in baseline age, gender, education level, medical history, smoking history, SCD‑Q9 score and MoCA score between the progressive group and the non‑progressive group (all P>0.05). The 24 h SCV in the progressive group was significantly higher than that in the non‑progressive group [13.4% (9.9%, 15.6%) vs 10.9% (9.7%, 12.7%), U=594.50, P= 0.016]. There was no significant difference in 24 h DCV between the two groups (P>0.05). In progressive group, the 24 h SCV was negatively correlated with MoCA score difference (r=-0.368, P= 0.021). Conclusion There is a correlation between ambulatory blood pressure variability and SCD progression, high 24 h SCV may be one of the factors of SCD progression and has certain predictive value. © 2023 Chinese Journal of Health Management. All rights reserved.