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1.
蒲黄系香蒲科属(rPha)植物水烛的花粉。《本草纲目》记载:"蒲黄手足厥阴血分药也,故能治血治痛,生则能行,熟则能止,与五灵脂同用,能治一切心腹诸痛"。近些年来;临床发现单味蒲黄对降低血清胆固醇和血小板粘附率有较好的作用,可用于治疗冠心病。为开发药源,我们进行了实验研究,发现香蒲叶有降血脂和抗氧化作用,因而进一步研究了香蒲叶的凝血机制和一般药理实验。现将结果报告如下。一、香蒲叶的急性毒性实验取体重18~22g小鼠60只分成5组,分别口服不同剂量的香蕉叶提取物,观察1周内动物的死亡数,用简化冠氏法计算LD50为生… 相似文献
2.
目的观察西洛他唑对兔动脉粥样硬化斑块组织的影响,进一步探讨西洛他唑抗动脉粥样硬化作用及其可能机制。方法将30只新西兰雄性白兔随机分为正常对照组、高脂饮食组和西洛他唑组。酶法检测血脂,免疫沉淀法测定血清C反应蛋白水平,免疫组织化学检测基质金属蛋白酶9和核因子κB的表达,病理形态学分析各组主动脉内膜厚度和斑块面积,逆转录聚合酶链反应检测血管组织单核细胞趋化蛋白1mRNA的表达。结果实验第12周末,西洛他唑组总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平低于高脂饮食组,但高于正常对照组(P均<0.01);西洛他唑组主动脉内膜厚度和斑块面积低于高脂饮食组,但大于正常对照组(P均<0.01);西洛他唑组核因子κB、单核细胞趋化蛋白1和基质金属蛋白酶9的表达弱于高脂饮食组,但强于正常对照组(P均<0.01)。结论西洛他唑有抗动脉粥样硬化作用,其作用机制可能与下调核因子κB、单核细胞趋化蛋白1及基质金属蛋白酶9的表达有关。 相似文献
3.
Objective To explore the effect of erythropoietin (EPO) on angiotensin Ⅱ (Ang Ⅱ) induced neonatal rat cardiomyocyte hypertrophy and the association with PI3K/Akt-eNOS signaling pathway. Methods Cardiomyocytes were isolated from new-born Sprague-Dawley rats and stimulated by Ang Ⅱ in vitro. The cell surface area and mRNA expression of atrial natriuretic factor (ANF) of cardiomyocytes were determined in the presence and absence of various concentrations of EPO, phosphatidylinositol 3'-kinase (PI3K) inhibitor LY294002 and nitric oxide synthase (NOS) inhibitor L-NAME. Intracellular signal molecules, such as Akt, phosphorylated Akt, eNOS and phosphorylated eNOS protein expressions were detected by western blot. Nitric oxide (NO) level in the supernatant of cultured cardiomyocytes was assayed by NO assay kit. Results EPO (20 U/ml) significantly inhibited Ang Ⅱ induced cardiomyocyte hypertrophy as shown by decreased cell surface area and ANF mRNA expression (all P <0.05). EPO also activated Akt and enhanced the expression of eNOS and its phosphorylation (all P < 0.05), increased the NO production (P <0.01). These effects could be partially abolished by cotreatment with LY294002 or L-NAME (all P < 0.05). Conclusion EPO attenuates Ang Ⅱ induced cardiomyocytes hypertrophy via activating PI3K-Akt-eNOS pathway and promoting NO production. 相似文献
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依那普利治疗难治性肾病综合征疗效观察 总被引:2,自引:0,他引:2
依那普利治疗难治性肾病综合征疗效观察卢振华,李紫禾难治性肾病综合征通常指对肾上腺皮质激素(简称激素)治疗反应不佳的原发性肾病综合征。本文应用依那普利(常州制药厂生产)治疗11例难治性肾病综合征,疗效较满意。11例均为经激素和/或免疫抑制剂正规治疗无效... 相似文献
7.
本刊讯2012年度全国卫生专业技术资格考试安排已经确定,报名工作于2011年12月20日全面启动。根据人力资源和社会保障部、卫生部办公厅近日下发的《关于2012年度卫生专业技术资格考试工作有关问题 相似文献
8.
Objective To explore the effect of erythropoietin (EPO) on angiotensin Ⅱ (Ang Ⅱ) induced neonatal rat cardiomyocyte hypertrophy and the association with PI3K/Akt-eNOS signaling pathway. Methods Cardiomyocytes were isolated from new-born Sprague-Dawley rats and stimulated by Ang Ⅱ in vitro. The cell surface area and mRNA expression of atrial natriuretic factor (ANF) of cardiomyocytes were determined in the presence and absence of various concentrations of EPO, phosphatidylinositol 3'-kinase (PI3K) inhibitor LY294002 and nitric oxide synthase (NOS) inhibitor L-NAME. Intracellular signal molecules, such as Akt, phosphorylated Akt, eNOS and phosphorylated eNOS protein expressions were detected by western blot. Nitric oxide (NO) level in the supernatant of cultured cardiomyocytes was assayed by NO assay kit. Results EPO (20 U/ml) significantly inhibited Ang Ⅱ induced cardiomyocyte hypertrophy as shown by decreased cell surface area and ANF mRNA expression (all P <0.05). EPO also activated Akt and enhanced the expression of eNOS and its phosphorylation (all P < 0.05), increased the NO production (P <0.01). These effects could be partially abolished by cotreatment with LY294002 or L-NAME (all P < 0.05). Conclusion EPO attenuates Ang Ⅱ induced cardiomyocytes hypertrophy via activating PI3K-Akt-eNOS pathway and promoting NO production. 相似文献
9.
Objective To explore the effect of erythropoietin (EPO) on angiotensin Ⅱ (Ang Ⅱ) induced neonatal rat cardiomyocyte hypertrophy and the association with PI3K/Akt-eNOS signaling pathway. Methods Cardiomyocytes were isolated from new-born Sprague-Dawley rats and stimulated by Ang Ⅱ in vitro. The cell surface area and mRNA expression of atrial natriuretic factor (ANF) of cardiomyocytes were determined in the presence and absence of various concentrations of EPO, phosphatidylinositol 3'-kinase (PI3K) inhibitor LY294002 and nitric oxide synthase (NOS) inhibitor L-NAME. Intracellular signal molecules, such as Akt, phosphorylated Akt, eNOS and phosphorylated eNOS protein expressions were detected by western blot. Nitric oxide (NO) level in the supernatant of cultured cardiomyocytes was assayed by NO assay kit. Results EPO (20 U/ml) significantly inhibited Ang Ⅱ induced cardiomyocyte hypertrophy as shown by decreased cell surface area and ANF mRNA expression (all P <0.05). EPO also activated Akt and enhanced the expression of eNOS and its phosphorylation (all P < 0.05), increased the NO production (P <0.01). These effects could be partially abolished by cotreatment with LY294002 or L-NAME (all P < 0.05). Conclusion EPO attenuates Ang Ⅱ induced cardiomyocytes hypertrophy via activating PI3K-Akt-eNOS pathway and promoting NO production. 相似文献
10.
目的:探讨临时起搏器在非心脏手术中常合并有心脏起搏及传导系统的功能障碍应用的必要性。方法:对60例合并缓慢型心律失常的外科患者在手术前1天或术前4h植入心脏临时起搏器,术中和术后行心电图监测记录,观察起搏器的工作状态。结果:60例中起搏器起搏有71.67%,其中严重窦性心动过缓、Ⅱ度AVB、房颤伴长间歇(>2s)和双束支阻滞的患者临时起搏器工作状态多,患者合并心肌梗死和心肌病时,是术中发生严重缓慢性心律失常的高危人群,具有临时起搏器植入的明显指征。结论:在非心脏手术中合并有缓慢型心律失常、Ⅱ度AVB、房颤伴R-R长间歇和双束支阻滞者在行外科手术前植入心脏临时起搏器可以为手术的顺利进行提供安全保障。 相似文献