田林县基本消灭疟疾后的监测结果分析

田林县是以微小按蚊为主要媒介的恶性疟和间日疟混合流行的疟疾高发区之一。 1991年经自治区组织专家考核 ,确认达到基本消灭疟疾标准。 1992年起展开了防止疟疾复燃与巩固发展灭疟成果工作。现将 1992年～ 1999年疟疾监测结果报告如下。防治内容与方法　　 1.病例侦察和治疗　加强全县各村屯巡回侦察工作 ,通过主动和被动侦察 ,对初诊为疟疾、疑似疟疾、疑似感冒和发热原因不明的发热 (四热 )病人取血镜检 ,对诊断为疟疾、疑似疟疾的发热病人取血后即给予假定性治疗 ,即氯喹 0 .6 ｇ ,伯氨喹啉 15ｍｇ ;对确诊的现症病人或带虫者均给予氯喹…     

边远村屯疟疾的监测与防制措施

田林县是以微小按蚊为主要媒介的恶性疟和间日疟混合流行的疟疾高发区之一。1956年和1970年曾两次发生疟疾暴发流行。经过几十年积极综合防制,疟疾发病率从1956年的316.3/万,下降至1991年的0.277/万,经自治区组织验收达到基本消灭疟疾标准。要防止疟疾复燃,巩固发展灭疟成果,加强边远村屯疟疾的监测是一项根本的措施,现将监测结果及防制对策作一讨论。资料与方法　　1.基本情况　田林县地处云贵高原边缘的桂西北部,海拔在2000～2062米之间,总面积为5577ｋｍ2,东与乐业、凌云、百色毗邻,西与隆林、西林两县交界,南与云南的富宁、广南两县接壤…     

2014年田林县手足口病疫情分析

目的了解和分析田林县2014年手足口病的流行特征,为制定手足口病防控措施提供参考。方法通过收集疫情报告系统中手足口病报告信息,同时对田林县医院门诊及住院病例随机采集咽拭子或粪便标本进行检测,采用描述性流行病学方法描述2014年田林县手足口病的流行特征,分析病原检测结果。结果2014年田林县共报告手足口病例2326例,发病率为905.06/10万,其中重症病例75例（占3.22%）,死亡3例,病死率为0.13%;男性高于女性（P≤0.05）;发病高峰为4—6月;5岁及以下儿童发病数占92.48%,散居儿童发病数占84.26%;实验室检测病毒核酸阳性60例,检测阳性率为76.92%,其中EV71阳性35例（占58.33%）,CoxA16阳性11例（占18.33%）,其他肠道病毒14例（占23.33%）。结论田林县手足口病发病率较高,防控工作重点为散居儿童。     

2014年田林县麻疹暴发疫情分析

目的 分析田林县2014年麻疹暴发疫情的流行病学特征和发生原因,为今后当地麻疹的防治提供参考.方法 收集该县2014年各乡镇麻疹病例疫情报告和处置资料,对病例进行流行病学调查和分析.结果 2014年该县出现麻疹暴发流行持续6个月,流行高峰出现在1、2月,报告麻疹病例共105例,发病率为40.72/10万,无死亡病例.8月龄至3岁婴幼儿占总病例数的24.76%,未免疫接种或接种史不详者占92.30%,散居儿童占病例的46.67%.发病前7~21天有到医院就诊或治疗史者占52.38%.结论 常规免疫接种率低及存在免疫薄弱区或空白点是本次麻疹疫情暴发的主要原因.     

Analysis of clinical features in children with McCune-Albright syndrome北大核心CSCD

Objective To summarize and analyze the clinical features of McCune-Albright syndrome (MAS) in 26 children, to improve the understanding of MAS diagnosis and treatment, and to achieve early clinical diagnosis of MAS. Methods The clinical data of 26 children with MAS treated in Department of Pediatrics, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from August 2011 to June 2021 were retrospectively analyzed.Their clinical characteristics were summarized and studied.t-test, Mann-Whitney U test, χ 2 test or Fisher′s exact probability method was used for comparison between groups. Results (1) Among the 26 MAS patients enrolled, there were 22 females and 4 males.The average onset age of female and male patients was (5.87±2.94) years old and (7.48±3.36) years old, respectively.(2) In female patients, there were 7 cases with the typical triad and 15 cases with the atypical triad.(3) Female patients had the first symptom of vaginal bleeding (8/22) and breast development (14/22). Among the 4 male children, 1 case had " fracture" and 3 cases " lagged behind their peers in height" at the first visit.(4) Compared with the breast development group, the vaginal bleeding group had an earlier onset age[(4.06±1.88) years old vs.(7.82±1.82) years old] (t=5.023, P<0.001), earlier bone maturation[(1.26±0.07) vs.(1.09±0.13)] (t=2.933, P<0.05), a greatly lowered predicted adult height[(-2.16±0.98) SDS vs.(-0.96±1.09) SDS](t=1.352, P<0.05), a lower blood phosphorus level[(1.41±0.14) nmol/L vs.(1.67±0.24) nmol/L] (t=1.941, P<0.05), and a significantly elevated alkaline phosphatase level[339(313, 656) U/L vs.243(205, 452) U/L] (U=1.000, P<0.05). All patients (8 cases) in the vaginal bleeding group had fibrous dysplasia of bone.(5) Ten patients progressed to central precocious puberty (CPP). They showed an older average age of onset[(7.27±2.69)years old vs.(4.69±2.68)years old] (U=44.000, P<0.05), significantly earlier bone maturation at diagnosis[(1.23±0.11) vs.(1.01±0.13)] (t=1.834, P<0.05), and a lower predicted adult height[(152.00±4.62) cm vs.(162.10±6.91) cm] (t=3.805, P<0.05), compared with those who did not progress to CPP.(6) Eleven children developed polyostotic fibrous dysplasia of bone, and most common type (8 cases) was polyostotic fibrous dysplasia of bone, primarily at lower limb bones and skulls.(7) Of the 26 children, 20 cases had scattered Café au lait pigments on the skin.The Café au lait pigmented skin lesions in 35% (7/20) cases crossed the midline. Conclusions With complicated clinical manifestations, MAS is more common and occurs earlier in girls than boys.It is difficult to clinically diagnose MAS in boys due to the insidious onset and atypical symptoms.Female MAS patients with vaginal bleeding as the first symptom usually have an early age of onset, advanced bone age and lower predicted adult height, so they should be monitored and evaluated clinically.Vaginal bleeding is significantly associated with polyostotic fiber dysplasia of bone in MAS patients.Therefore, it is recommended that patients with vaginal bleeding should undergo a routine bone single-photon emission computed tomography scan.This helps understand the situation of occult fiber dysplasia of bone.Patients with later diagnosis and advanced bone age should be aware of the possibility of progression to CPP. © 2022 Chinese Journal of Applied Clinical Pediatrics. All rights reserved.