排序方式: 共有19条查询结果,搜索用时 15 毫秒
1.
Zuccala G.; Pahor M.; Lattanzio F.; Vagnoni S.; Rodola F.; De Sole P.; Cittadini A.; Cocchi A.; Bernabei R. 《British journal of anaesthesia》1997,79(6):776-781
The use of high-dose magnesium infusions in critically ill and surgical
patients is increasing. This practice is associated with considerable risk
of toxicity, as no reliable criteria are currently available to detect
significant intracellular magnesium depletion. We have evaluated, before
and after surgery, 33 elderly patients with hip fracture, by 24-h Holter
ECG monitoring, Doppler echocardiography and serum chemistry; lymphocyte
magnesium was measured using atomic absorption spectrophotometry. The
severity of ventricular arrhythmias increased, and serum and mononuclear
magnesium concentrations decreased significantly after surgery. Decreases
in either serum magnesium concentrations > 0.125 mmol litre-1 or
cellular magnesium > 6 nmol mg- 1, but not serum or lymphocyte absolute
magnesium concentrations, were associated with postoperative development of
repetitive arrhythmias. Variations in serum magnesium concentrations
correlated with intracellular decreases, and yielded good accuracy in
predicting the postoperative worsening of arrhythmias. Thus perioperative
differences in serum magnesium concentrations reflected intracellular
variations and allowed us to identify patients with clinically relevant
cellular magnesium depletion.
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2.
Ezio Degli Esposti Carla Chiarini Andrea Gattiani Alessandra Sturani Franco Vecchi Alessandro Zuccala Pietro Zucchelli 《International Journal of Clinical & Laboratory Research》1979,9(2):147-153
Summary A study of the frequency distribution of plasma renin activity (PRA) in 123 patients with essential hypertension (EH) produced
no evidence of a distinct subpopulation with low renin levels, whether the samples were taken from supine or upright patients.
Applying an arbitraty classification criterion, however, low PRA levels were found in 30.1% of patients. There were no significant
differences in mean blood pressure, 24-h sodium excretion, and age when groups with low, normal or high PRA levels were compared.
The incidence of PRA hyporesponsiveness was similar in the three groups of patients, but increased with age. In the female
there was a preponderance of low PRA levels. It is concluded that EH with low PRA levels is not a separate diagnostic entity
and, when PRA is low in a hypertensive subject, the possible effects of age, blood pressure, and sex ought to be taken into
account before other causes of low PRA are postulated. 相似文献
3.
Hypertension is frequently present in glomerunephritis withoutrenal insufficiency but its pathogenesis is poorly understood.Eighty-five patients with glomerulonephritis and normal renalfunction, including 55 hypertensive patients, and 24 normalsubjects were studied to obtain data on the mechanisms responsiblefor hypertension. Plasma renin activity (PRA), plasma noradrenaline,total exchangeable sodium, and urinary prostaglandin E (PGE)were determined. Moreover, the autonomic nervous system wasexplored with the following tests: tilt test, diving reflex,lying down, and deep breathing tests. In 15 of the 30 normotensivepatients with glomerulonephritis, PRA was measured after theadministration of propranolol and then indomethacin. No significantdifferences were found in the mean values of PRA, plasma noradrenaline,total exchangeable sodium, urinary PGE, and autonomic nervoussystem behaviour between glomerulonephritis patients with andwithout hypertension or between hypertensive glomerulonephritispatients and control subjects. In many of the normotensive glomerulonephritispatients we found an elevated PRA that was normalised by propanololbut not by indomethacin. In summary, hypertension in glomerulonephritis is not associatedwith abnormalities in the sodium balance, with renin-angiotensinor with autonomic nervous system abnormalities. A renin hypersecretionseems to be present only in some normotensive patients withglomerulonephritis. 相似文献
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L. Carosella M.D. P. Menichelli M. Alimenti G. Zuccala A. Gemma A. Cocchi P. U. Carbonin 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1989,3(3):417-425
Summary Pharmacokinetics and pharmacodynamics of verapamil were studied in 11 elderly subjects (age=79.67±4.74 years) and in 11 middle-aged subjects (age=45±11.37 years) following intravenous (IV), single oral, and long-term oral administration.Plasma verapamil concentrations were determined using high-pressure liquid chromatography (HPLC). Twenty-four hour dynamic Holter electrocardiographic (ECG) recordings were employed to study heart rate (HR) and P-R interval.No difference in plasma half-life, distribution volume, body clearance, and area under the curve (AUC) was observed between the two groups after IV and oral verapamil administration.Blood pressure (BP) and HR were significantly reduced after verapamil IV administration in the elderly group only (p<0.05, p<0.01, respectively). After single and long-term oral administration, variable HR and BP responses were observed in both groups.The P-R prolongation following both IV and single oral doses exhibited a delay with respect to the peak plasma concentration, inducing a definite hysteresis loop. The slope of P-R variations (using a linear pharmacodynamic model) was greater in the elderly both after IV and single oral verapamil administration, but statistical significance was obtained only after the single oral dose (p<0.05). In the elderly group, after long-term oral administration, there was a significant prolongation of the P-R interval (p<0.0001) with respect to the corresponding time point of the 24-hour predrug period. Such variations in pharmacodynamic parameters in the elderly did not, however, cause any clinical problem.In conclusion, verapamil seems to be well tolerated in the elderly as well as in younger patients at similar dosages. However, its use in the elderly requires careful clinical evaluation. 相似文献
6.
Left ventricular dysfunction: a clue to cognitive impairment in
older patients with heart failure 总被引:6,自引:0,他引:6
G. Zuccala C. Cattel E. Manes-Gravina N Di A. Cocchi R. Bernabei 《Journal of neurology, neurosurgery, and psychiatry》1997,63(4):509-512
OBJECTIVES—Cognitive impairment has been reportedin middle aged patients with end stage heart failure. This crosssectional study assessed the prevalence and determinants of cognitivedysfunction in older patients with mild to moderate heart failure.
METHODS—57 consecutive patients (mean age 76.7 years) with chronic heart failure underwent physical examination, bloodchemistry, urinalysis, chest radiography ECG, Doppler echocardiography,and the mini mental state examination (MMSE), mental deterioration battery, depression scale of the Center for Epidemiological Studies (CES-D), Katz activities of daily living, and instrumental activities of daily living 24 hours before hospital discharge.
RESULTS—MMSE scores <24 were found in 53% ofparticipants. The MMSE score was associated with left ventricularejection fraction according to a non-linear correlation, so thatcognitive performance was significantly lower in subjects with leftventricular ejection fraction 30%. The same pattern of correlationwas evidenced between left ventricular ejection fraction and both theattention sub-item of MMSE and the Raven test score. In a multivariatelinear regression model, after adjusting for age, sex, and aseries of clinical data and objective tests, both age (β=−0.30;P=0.038) and the natural log of left ventricular ejection fraction(β=0.58; P=0.001) were associated with the MMSE score.
CONCLUSION—Cognitive impairment in olderpatients with chronic heart failure is common, and independentlyassociated with lower left ventricular ejection fraction. Giventhe overwhelming incidence and prevalence of heart failure in olderpopulations, early detection of cognitive impairment in these subjectswith prompt, intensive treatment of left ventricular systolicdysfunction may prevent or delay a remarkable proportion of dementia inadvanced age.
相似文献
METHODS—57 consecutive patients (mean age 76.7 years) with chronic heart failure underwent physical examination, bloodchemistry, urinalysis, chest radiography ECG, Doppler echocardiography,and the mini mental state examination (MMSE), mental deterioration battery, depression scale of the Center for Epidemiological Studies (CES-D), Katz activities of daily living, and instrumental activities of daily living 24 hours before hospital discharge.
RESULTS—MMSE scores <24 were found in 53% ofparticipants. The MMSE score was associated with left ventricularejection fraction according to a non-linear correlation, so thatcognitive performance was significantly lower in subjects with leftventricular ejection fraction 30%. The same pattern of correlationwas evidenced between left ventricular ejection fraction and both theattention sub-item of MMSE and the Raven test score. In a multivariatelinear regression model, after adjusting for age, sex, and aseries of clinical data and objective tests, both age (β=−0.30;P=0.038) and the natural log of left ventricular ejection fraction(β=0.58; P=0.001) were associated with the MMSE score.
CONCLUSION—Cognitive impairment in olderpatients with chronic heart failure is common, and independentlyassociated with lower left ventricular ejection fraction. Giventhe overwhelming incidence and prevalence of heart failure in olderpopulations, early detection of cognitive impairment in these subjectswith prompt, intensive treatment of left ventricular systolicdysfunction may prevent or delay a remarkable proportion of dementia inadvanced age.
相似文献
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ACE inhibition reduces proteinuria in normotensive patients with IgA nephropathy: a multicentre, randomized, placebo-controlled study 总被引:9,自引:4,他引:5
Maschio G.; Cagnoli L.; Claroni F.; Fusaroli M.; Rugiu C.; Sanna G.; Sasdelli M.; Zuccala A.; Zucchelli P. 《Nephrology, dialysis, transplantation》1994,9(3):265-269
A multicentre, randomized, placebo-controlled study was performedin 39 adult patients with biopsy-proven IgA nephropathy withthe aim of comparing the effects of the ACE inhibitor fosinopriland placebo on proteinuria. All patients had normal blood pressureand normal renal function. Proteinuria ranged from 1.0 to 2.5g/24 h. After a 3-month run-in period, fosinopril and placebowere randomly administered in two 4-month sequences separatedfrom crossover treatment by a 1-month interval. The mean valuesof creatinine clearance did not change during either the placeboor the treatment sequences. The mean values of mean arterialpressure (MAP) were significantly lower during the fosinoprilsequence (90.4 ±9.0 mmHg) than in basal conditions (92.8± 9.1 mmHg) (P=0.034). The mean basal values of proteinuriawere 1.74 ±0.84 g/24 h. They were unchanged during theplacebo sequence (1.79 ±1.20) and fell to 1.37 ±0.98g/24 h after 4 months of fosinopril treatment. Using a multivariatestatistical analysis, the treatment effect by time on proteinuriawas significantly evident only in the fosinopril sequence (Wilkstest, P=O.O33). Changes in protein excretion were not correlatedwith changes in MAP, baseline plasma renin activity, and urinarysodium excretion. This controlled study shows that fosinoprilcan significantly reduce proteinuria even in normotensive patientswith IgA nephropathy. Obviously, the results of treatment withACE inhibitors on long-term renal prognosis remain to be elucidated. 相似文献
10.
Wing Tai Kong Shawn Chopra Michael Kopf Carlos Morales Shahzad Khan Keith Zuccala Laura Choi John Chronakos 《Obesity surgery》2016,26(12):2886-2890