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AI GAO * BING-CI LIU* XIANG-LIN SHI? CHUAN-SHU HUANG? XIAO-WEI JIA* BAO-RONG YOU* MENG YE* FU-HAI SHEN* AND HONG-JU DU* *National Institute of Occupation Health Poison Control Chinese Center for Disease Control Prevention Beijing China ?National Institute for Occupational Safety Health Willowdale Road Morgantown WV USA ?Nelson Institute of Environmental Medicine New York University School of Medicine Old Forge Road Tuxedo NY 《Biomedical and environmental sciences : BES》2006,(3)
INTRODUCTION Polycyclic aromatic hydrocarbons (PAHs) such as B[a]P are widespread environmental contaminants formed as byproducts of combustion[1]. PAHs have been found to be potent mammary carcinogens in rodents[2-3]. It is believed that B[a]P requires biological activation through oxidative metabolism to be carcinogenic. The ultimate carcinogenic metabolite has been considered to be the cytochrome P450 isozyme- and microsomal epoxide hydrolase- derived metabolite, BPDE, which forms… 相似文献
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